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Molecular sieves are materials with pores of uniform size and diameter that are similar in size to small molecules; used to separate molecules by size; available in various pore size ranges, with drying solvent indicators, etc.
3A 4x8 Molecular Sieve is a multiple purpose, highly porous, high capacity alkali metal alumino-silicate in the spherical form. It is the potassium form of the Type A crystal structure with pore diameters of approximately 3Å. The 3Å pore opening will allow moisture to be adsorbed but will exclude unsaturated hydrocarbons and highly polar alcohols such as methanol and ethanol. It has high mass transfer efficiency and durability.
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Recombinant human Semaphorin-3A is a secreted guidance protein produced in HEK293 mammalian cells with an N-terminal His tag and supplied as a small research pack (2 μg). The product preserves native glycosylation and folding, exhibits an observed molecular weight of 60-73 kDa by SDS-PAGE, and has low endotoxin levels suitable for many cell-based and biochemical assays. Aliquot and store frozen to maintain activity.
Preserves mammalian glycosylation and native folding
Low endotoxin suitable for cell-based assays
N-terminal His tag simplifies purification and detection
Small research pack size ideal for pilot studies
Observed molecular weight 60-73 kDa due to glycosylation
Stable when aliquoted and stored frozen
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Nutlin-3a (Rebemadlin) is a research-grade small molecule that antagonizes MDM2, disrupting the MDM2-p53 interaction to stabilize wild-type p53 and trigger apoptosis and autophagy. It is used in preclinical studies to probe p53-dependent cancer biology and cellular stress responses.
Inhibits MDM2-p53 interaction.
Stabilizes wild-type p53 protein.
Induces apoptosis and autophagy in p53-competent cells.
Reported IC50 approximately 90 nM in biochemical assays.
Molecular formula C30H30Cl2N4O4; molecular weight 581.49 g/mol.
Suitable for in vitro and preclinical research applications.
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SMI-4a (CAS 438190-29-5) is a selective inhibitor of the serine/threonine kinase Pim-1 exhibiting an IC50 of 17 nM Pim-1 is implicated in the regulation of cell cycle progression and apoptosis with its overexpression associated with enhanced cell survival in various malignancies SMI-4a demonstrates increased activity compared to related compounds and inhibits downstream mTORC1 signaling and activates AMPK in leukemia cell lines leading to cell cycle arrest and apoptosis induction In preclinical studies SMI-4a reduced tumor volume in xenograft mouse models highlighting its utility for investigating Pim kinase-driven pathways in cancer research
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SMI-4a (CAS 438190-29-5) is a selective inhibitor of the serine/threonine kinase Pim-1 exhibiting an IC50 of 17 nM Pim-1 is implicated in the regulation of cell cycle progression and apoptosis with its overexpression associated with enhanced cell survival in various malignancies SMI-4a demonstrates increased activity compared to related compounds and inhibits downstream mTORC1 signaling and activates AMPK in leukemia cell lines leading to cell cycle arrest and apoptosis induction In preclinical studies SMI-4a reduced tumor volume in xenograft mouse models highlighting its utility for investigating Pim kinase-driven pathways in cancer research
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Nutlin-3a chiral (CAS 675576-98-4) is a small-molecule antagonist targeting mouse double minute 2 (MDM2) which functions as a negative regulator of the tumor suppressor TP53 By binding directly to the TP53-interacting pocket of MDM2 Nutlin-3a blocks the degradation of TP53 stabilizing the protein and activating TP53-dependent pathways Studies in solid tumors and lymphomas indicate that Nutlin-3a induces cell cycle arrest growth inhibition and apoptosis Research has demonstrated antitumor activity in vitro and in vivo highlighting its utility in studying TP53-related cell signaling pathways and its potential in cancer research applications
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