Siliconizing Fluids
Apexbio Technology LLC PMX 205 Trifluoroacetate 514814-49-4 (free base) 500ug
PMX 205 Trifluoroacetate is a cyclic hexapeptide antagonist targeting the complement C5a receptor (C5aR CD88) It is designed to competitively inhibit C5a binding to its receptor thereby modulating complement-mediated inflammatory pathways PMX 205 Trifluoroacetate exerts its biological activity primarily through competitive antagonism at C5aR reducing downstream inflammatory cellular responses In animal models PMX 205 Trifluoroacetate demonstrates anti-inflammatory effects Based on these pharmacological properties PMX 205 Trifluoroacetate holds research potential in the study of neuroinflammation Alzheimer s disease and chemically induced colitis
Medchemexpress LLC PMX 205 Trifluoroacetate | 99.50% | 953.06 | 1 ML
PMX 205 Trifluoroacetate is a specific complement C5aR1 isoform antagonist. It is intended for research use only and not for sale to patients.
- Specific complement C5aR1 isoform antagonist.
- Purity of 99.50%.
- Molecular weight of 953.06.
- Chemical formula is C47H63F3N10O8.
- Appears as a white to off-white solid.
- Soluble in DMSO at ≥ 100 mg/mL.
- Shows significant inhibition of cell viability in MTT assays.
- Functions as an orally active, selective C5aR antagonist in rats.
- Reduces fibrillar plaque load in Tg2576 mice.
- Significantly reduces hyperphosphorylated tau in 3xTg mice.
Crescent Chemical Co Inc SERVA TRIS-GLYCINE NATIVE BUFF
SERVA Tris-Glycine native sample buffer (2x) Sample buffer for native PAGE. Supplied as 2 x concentrate. Contains 126 mM Tris/HCl (pH 6.8), 20 % glycerol and 0.02 % bromophenol blue. Size - 20ML Storage Conditions - +2 °C TO +8 °C Catalog Number - 42528.01
Crescent Chemical Co Inc SERVA TRIS-GLYCINE NATIVE BUFF
SERVA Tris-Glycine native electrophoresis buffer (10x) Running buffer for native PAGE. Supplied as 10 x concentrate. Contains 250 mM Tris, 1.92 M glycine. Size - 1L Storage Conditions - +2 °C TO +8 °C Catalog Number - 42530.01
Cell Signaling Technology SignalSilence(R) beta-Catenin siRNA I 300 ul
SignalSilence(R) beta-Catenin siRNA I 300 ul
Cell Signaling Technology SARS-CoV-2 Spike RBD 318-541
SARS-CoV-2 Spike RBD (318-541) Recombinant Protein (mFc-Tag) 100 ug
Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide | 133550-41-1 | 99.9% | 336.39 g/mol | C20H20N2O3 | 1 ML
(E)-AG 556 is a small-molecule, selective inhibitor of the epidermal growth factor receptor (EGFR) used in preclinical research to probe EGFR-mediated signaling and inflammatory responses. It inhibits EGFR kinase activity and has been reported to reduce LPS-induced TNF-α production. The compound is supplied as a high-purity powder and is also available as a ready-to-use 10 mM stock solution in 1 mL vials for convenient dosing in cellular and biochemical assays.
- Selective EGFR inhibitor for signaling studies.
- Reported to block LPS-induced TNF-α production in cell assays.
- High purity suitable for biochemical and cell-based assays.
- Available as powder and as a 10 mM stock solution for immediate use.
- Molecular formula C20H20N2O3 and molecular weight 336.39 g/mol.
Cell Signaling Technology Human ACE2 (multimeric) (18-652) Recombinant Protein 20 ug
Human ACE2 (multimeric) (18-652) Recombinant Protein 20 ug
Medchemexpress LLC L-Arginine, N2-(1-oxo-3-phenylpropyl)-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl- | 514814-49-4 | 99.5% | 839.04 | 25 MG
PMX 205 is a potent and orally active complement C5a receptor (C5aR; CD88) antagonist. This selective C5aR antagonist is supplied in solid form as a white to off-white powder.
- Potent complement C5a receptor (C5aR; CD88) antagonist
- Orally active and selective C5aR antagonist
- Showed significant results in MTT assays
- Extended survival time and reduced end-stage motor scores in a rat model of amyotrophic lateral sclerosis
- Reduced astroglial proliferation in SOD1G93A rats
- Reduced fibrillar plaque load in Tg2576 mice
- Reduced hyperphosphorylated tau (69%) in 3xTg mice
- Blocked C5a-stimulated increase in CD44 expression in PECs
- Reversed C5a-increased PEC-derived COL4A2 secretion
- Reduced C5a-increased proliferation of PECs
- Induced suppression of GPX4 expression and inhibition of tumor growth in mice
Crescent Chemical Co Inc SILICONE ANTI-FOAM EMULSION
Silicone anti-foam emulsion, 30 % Dow Corning 30 % polydimethylsiloxane in water; contains traces of emulsifiers derived from plant. Size - 500ML Storage Conditions - +15 C TO +30 C Catalog Number - 35119.02