Loratadine-d5 is a deuterium labeled variant of Loratadine, a selective inverse peripheral histamine H1-receptor agonist. This compound shows anti-dengue-virus (DENV) activity and can inhibit the immunologic release of inflammatory mediators, with an IC50 of >32 μM. It is intended for research use only, serving as a valuable tool in drug development and quantitative analysis due to its stable heavy isotope labeling.
- Can be used as a tracer in research studies.
- Serves as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Exhibits anti-dengue-virus (DENV) activity.
- Inhibits the immunologic release of inflammatory mediators.
- Deuteration may affect the pharmacokinetic and metabolic profiles of drugs.