Bay-850 is a small-molecule chemical probe that selectively inhibits ATPase family AAA domain-containing protein 2 (ATAD2). It is characterized as a potent, isoform-selective ATAD2 inhibitor (IC50 166 nM) used in biochemical and cell-based studies to probe ATAD2 function, disrupt ATAD2-chromatin interactions, and induce bromodomain dimerization.
- Potent, isoform-selective ATAD2 inhibition (IC50 166 nM).
- Induces ATAD2 bromodomain dimerization and disrupts ATAD2-chromatin interaction.
- High purity suitable for biochemical assays (98.3% by HPLC).
- Powder form, readily soluble in DMSO for stock solutions.
- Molecular weight 654.24 g/mol; formula C38H44ClN5O3.
- Available with COA and RP-HPLC report for analytical verification.