Epredia™ Lab Vision™ DOG1 Rabbit Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with Epredia™ Dog1, Rabbit Monoclonal Antibody, part of a comprehensive antibody portfolio.

Catalog Number	Mfr. No.	Form	Quantity
RM9132S0	Epredia™ RM9132S0	Concentrated	100 μL
RM9132R1	Epredia™ RM9132R1	Prediluted	1 mL
RM9132R7	Epredia™ RM9132R7	Prediluted	7 mL
RM9132RQ	Epredia™ RM9132RQ	Ready-to-Use	12 mL

Description

DOG1 is a cell surface protein of unknown function selectively expressed in GIST. Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosin kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.

Host Species: Rabbit

Clone: SP31

Isotype: IgG

Species Reactivity: Human. Others not known.

Immunogen: Synthetic peptide of human DOG1

Molecular Weight: 78 kDa

Positive Control: Gastrointestinal Stromal Tumors

Cellular Localization: Cytoplasmic and Membranous

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Specifications

• Antigen: DOG1
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Regulatory Status: IVD
• Immunogen: Synthetic peptide of human Dog1

• Clone: SP31
• Classification: Monoclonal
• Host Species: Rabbit
• Research Discipline: Cancer and Tumor Biology
• Primary or Secondary: Primary