HER-2/c-erbB-2/neu Ab-4 Mouse Monoclonal Antibody, Epredia™

Provide accurate, reproducible results with the Epredia™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.

Catalog Number	Mfr. No.	Conjugate	Concentration	Quantity
MS301B	Epredia MS301B	Biotin	200μg/mL	1 mL
MS301P0	Epredia MS301P0	Unconjugated	200μg/mL	100 μL
MS301P1	Epredia MS301P1	Unconjugated	200μg/mL	500 μL
MS301P	Epredia MS301P	Unconjugated	200μg/mL	1 mL
MS301B0	Epredia MS301B0	Biotin	200μg/mL	100 μL
MS301B1	Epredia MS301B1	Biotin	200μg/mL	500 μL
MS301P1ABX	Epredia MS301P1ABX	Unconjugated	1mg/mL	100 μL
MS301PABX	Epredia MS301PABX	Unconjugated	1mg/mL	200 μL

Description

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: N12

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: Intact SKBR-3 breast cancer cells

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

• Immunofluorescence
• Immunoprecipitation (Not suitable)
• Inhibits Tumor Growth (∽90%)
• Inhibits Cell Proliferation
• Effect on HER-2 Internalization (Moderate)
• Electron Microscopy

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: HER-2/c-erbB-2/neu Ab-4
• Applications: Immunofluorescence, Immunohistochemistry (Frozen)
• Form: Concentrated
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1

• Clone: N12
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: EGFR Family
• Immunogen: Intact SKBR-3 breast cancer cells
• Primary or Secondary: Primary