Carbohydrates
Apexbio Technology LLC DL-α-Hydroxyglutaric acid disodium salt 40951-21-1 50mg
DL- -Hydroxyglutaric acid disodium salt (CAS 40951-21-1) is a small molecule analogue of -hydroxyglutaric acid a metabolite implicated in neurometabolic disorders In humans aberrant accumulation of D- -hydroxyglutaric acid occurs in D-2-hydroxyglutaric aciduria associated with mutations in isocitrate dehydrogenase (IDH) enzymes particularly IDH1 and IDH2 These mutations alter normal metabolic flux leading to overproduction of D- -hydroxyglutaric acid from 2-oxoglutarate In preclinical studies elevated levels of this metabolite are detectable in IDH1-mutant glioma models and non-invasive quantification is feasible via magnetic resonance spectroscopy DL- -Hydroxyglutaric acid disodium salt is utilized in research investigating metabolic dysregulation biomarker development and disease mechanisms linked to IDH mutations and gliomagenesis
