Carbohydrates
Apexbio Technology LLC PSB 1114 500ug
PSB 1114 is a small-molecule agonist targeting the purinergic P2Y2 receptor It is designed to selectively activate the P2Y2 receptor a G protein-coupled receptor (GPCR) naturally activated by extracellular nucleotides thereby regulating downstream signaling pathways such as chloride ion secretion mucosal hydration and inflammatory responses PSB 1114 exerts its biological activity primarily through P2Y2 receptor activation It demonstrates subtype selectivity within the P2Y receptor family with an EC50 value of approximately 0 134 M for the P2Y2 receptor and exhibits lower affinity towards related subtypes Based on these pharmacological properties PSB 1114 holds research potential in studies exploring therapeutic approaches for respiratory diseases including cystic fibrosis via modulation of ion transport and mucosal hydration mechanisms mediated by P2Y2 receptor activation
FUJIFILM BIOSCIENCES INC CultureSure 5mmol/L SB431542 D
This is a ready-to-use 5 mmol/L solution of SB431542 in dimethyl sulfoxide DMSO specifically formulated as animal-SB431542 inhibits ALK4 5 7 Reports on the simulation of formation of mono-layers differentiation and proliferation of embryonic stem cell-derived endothelial cells Otherwise this reagent when used together with thiazovivin and PD0325901 increases the reprogramming efficiency by 200 fold as well as accelerates reprogramming Ogawa K et al J Cell Sci 120 55 2007 Lin T et al Nat Methods 6 805 2009
Medchemexpress LLC Isrib (trans-isomer) | 1597403-47-8 | 99.49% | 451.34 | 50 MG
ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. It effectively reverses the effects of eIF2α phosphorylation and reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress. This trans-isomer is 100-fold more potent than cis-ISRIB, demonstrating stereospecific interaction with its cellular target.
- Potently reverses eIF2α phosphorylation (IC50=5 nM)
- Blocks eIF2α phosphorylation-induced stress granule (SG) formation
- Increases long-term memory in rodents
- Readily crosses the blood-brain barrier
Cell Signaling Technology SARS-CoV-1 Spike Protein E7C5
SARS-CoV-1 Spike Protein (E7C5Y) Rabbit mAb 100 ul
Cell Signaling Technology Phospho-PDGF Receptor alpha T
Phospho-PDGF Receptor alpha (Tyr762) (D9B1N) Rabbit mAb 100 ul
eMolecules 147388-83-8 | Medchem Express | ABT-418 (hydrochloride) | 5mg | 536983825 | HY-105170B | MFCD11045960 | 202.68 | C9H15ClN2O
Medchem Express | Claficapavir | 5mg | 736631117 | HY-145560 | 2055732-24-4 | 393.860 | C17H12ClNO4S2
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Medchemexpress LLC IKK alpha + IKK beta Antibody (YA349) | Protein A affinity purified | Predicted band size: 87 kDa; Observed band size: 87 kDa | 100UL
IKK alpha + IKK beta Antibody (YA349) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting IKK alpha + IKK beta. IKKβ protein, a serine kinase, plays a pivotal role in the NF-kappa-B signaling pathway, activated by diverse stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or cellular stresses. As a constituent of the canonical IKK complex, IKKβ contributes to the conventional NF-kappa-B activation pathway.
- Suitable for Western blot (1:500-1:1000)
- Suitable for immunocytochemistry/immunofluorescence (1:100-1:500)
- Suitable for immunoprecipitation (assay dependent concentration)
- Targets inhibitors of NF-kappa-B for degradation
- Enables free NF-kappa-B nuclear translocation and gene activation
- Phosphorylates various signaling pathway components
- Influences diverse cellular processes and responses
![Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 1mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000096670.png-250.jpg)
Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 1mg
Heparin cofactor II precursor fragment is a thrombin inhibitor peptide targeting human thrombin (factor IIa) It is designed to inhibit thrombin activity thereby modulating blood coagulation pathways Heparin cofactor II precursor fragment exerts its biological activity primarily through serine protease inhibition facilitated in the presence of heparin or dermatan sulfate Based on these pharmacological properties heparin cofactor II precursor fragment holds research potential in investigating thrombin inhibition mechanisms blood coagulation pathways and conditions associated with altered coagulation such as heparin cofactor II deficiency and hypercoagulability disorders
Alkali Scientific p Nitrophenyl α D mannopyranoside, 500 Mg
p-Nitrophenyl α-D Mannopyranoside, 500mg, is a biochemical reagent used for studying α-mannosidase activity. This compound serves as a substrate for α-mannosidase, where the enzyme cleaves the bond between the p-nitrophenyl group and the α-D-mannopyranoside molecule, releasing a yellow product. This colorimetric reaction is commonly used in enzyme assays to study enzyme kinetics, carbohydrate metabolism, and for genetic research. The 500mg size is suitable for multiple experiments or larger-scale studies. It is commonly used in laboratory assays to monitor enzyme activity, particularly in microbiological studies and enzyme research, providing a reliable and simple method for enzyme analysis.
![Alkali Scientific IPTG [Isopropyl β D thiogalactopyranoside], Dioxane Free, 400 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000659729.jpg-250.jpg)
Alkali Scientific IPTG [Isopropyl β D thiogalactopyranoside], Dioxane Free, 400 G
Isopropyl β-D-thiogalactopyranoside (IPTG) is a molecular biology reagent used for inducing gene expression in bacterial cultures. This dioxane-free formulation provides a non-metabolizable substrate that activates the lac operon in recombinant E. coli strains carrying the lacZ gene or other inducible systems. The compound acts as a powerful inducer of gene expression, triggering the synthesis of proteins under the control of the lac promoter. IPTG is commonly used in enzyme assays, protein production, and gene expression studies, making it essential for cloning and recombinant DNA technology. This 400g bulk format is ideal for large-scale applications in molecular biology research.
![Alkali Scientific LB Agar, Low Salt Formula, Powder [Lennox Agar], 100 Grams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000659719.jpg-250.jpg)
Alkali Scientific LB Agar, Low Salt Formula, Powder [Lennox Agar], 100 Grams
LB Agar, Low Salt Formula (Lennox Agar), 100 Grams, is a specialized bacterial growth medium that minimizes the salt content, making it ideal for sensitive bacterial strains that require less ionic strength in the environment. This medium is used for the cultivation of a wide variety of bacteria, including those for genetic research, bacterial transformations, and cloning. It is essential in many microbiological experiments requiring low salt concentrations.
Medchemexpress LLC Galactose 1-phosphate potassium salt | 2255-14-3 | 260.14 | 1 ML
Galactose 1-phosphate is an intermediate in galactose metabolism and nucleotide sugars. This product is provided as a potassium salt, which typically offers enhanced water solubility and stability, and is intended for research use only.
- Intermediate in galactose metabolism and nucleotide sugars
- Enhanced water solubility
- Enhanced stability
- For research use only