Carbohydrates
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Medchemexpress LLC Heparin calcium (MW 3600-5000) | 37270-89-6 | 3600-5000 Da | 100 MG
Heparin calcium (MW 3600-5000) is the calcium salt form of heparin, a polydisperse sulfated glycosaminoglycan anticoagulant supplied as a solid for research use. It acts by binding antithrombin III, accelerating inactivation of thrombin and other activated clotting factors to prevent fibrin formation. Supplied in low-molecular-weight fractions with an average molecular weight range of 3600-5000 Da.
- Anticoagulant action via antithrombin III binding.
- Low molecular weight range: 3600-5000 Da.
- Calcium salt supplied as a solid form.
- Intended for research use only, not for clinical use.
- Common pack size: 100 mg.
Medchemexpress LLC Complement factor D-IN-1 | 1386455-76-0 | 98.9% | 483.32 g·mol⁻1 | C21H19BrN6O3 | 10 MG
Complement factor D-IN-1 is a potent, selective, small-molecule reversible inhibitor of complement factor D intended for research into complement system biology and complement-mediated inflammation. It has been characterized in biochemical assays and is supplied as solid or solution for laboratory studies.
- Potent inhibitory activity: IC50 = 0.006 μM (FD thioesterolytic assay) and IC50 = 0.05 μM (MAC deposition assay).
- High reported purity (~98.9%); consult lot-specific COA for exact value.
- Supplied as solid or as DMSO solution for flexible experimental workflows.
- Stable storage: powder at -20°C (long term) or 4°C; in solvent, -80°C recommended.
- Molecular weight 483.32 g·mol⁻1 and formula C21H19BrN6O3 for analytical reference.
- For research use only; not for human or clinical applications.
Medchemexpress LLC D-Glucuronic acid (standard) | 6556-12-3 | 250 MG
D-Glucuronic acid (Standard) is an analytical standard for research and analytical applications. It is a key component of anti-inflammatory proteoglycans, promoting embryonic development and inhibiting cell aggregation. Metabolized into ethyl glucuronide, it activates Toll-like receptor 4 (TLR4), potentially causing pain. This compound and its derivative glucurono-lactone act as liver detoxifiers, with derivatives also showing anti-tumor activity. It is utilized in qualitative, quantitative, and methodological research, particularly with techniques like HPLC, GC, and MS.
- Purity: 99.93%
- Molecular weight: 194.14
- Chemical formula: C6H10O7
- Appearance: Solid, white to off-white
- Promotes embryonic development
- Liver detoxifier
Medchemexpress LLC Complement factor D-IN-2 | 1903742-34-6 | 99.33% | 574.43 | 25 MG
Complement factor D-IN-2 is an inhibitor of complement factor D, extracted from patent WO2015130838A1, compound 190. It targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway, and can be used for the research of autoimmune diseases.
- Reduces the excessive activation of complement factor D.
- Targets factor D and inhibits the complement cascade.
- Suitable for research of autoimmune diseases.
- For research use only.
Medchemexpress LLC D-Glucose, O-α-D-glucopyranosyl-(1→6)-O-α-D-glucopyranosyl-(1→4)- | 33401-87-5 | 99.95% | 504.44 | 25 MG
D-Panose is an oligosaccharide composed of glucose units linked by specific glycosidic bonds. It is a PAN-type oligosaccharide and a food ingredient based on isomaltooligosaccharides (IMOs). It can be detected with high sensitivity in SALDI-MS using magnesium oxide nanoparticles as the matrix.
- Composed of glucose units.
- PAN-type oligosaccharide.
- Food ingredient based on isomaltooligosaccharides (IMOs).
- High sensitivity detection in SALDI-MS.
- For research use only.
Medchemexpress LLC PROTAC BET degrader-1 | 2093386-22-0 | 99.4% | 871.90 g·mol⁻¹ | C44H45N11O9 | 25 MG
PROTAC BET Degrader-1 is a proteolysis-targeting chimera that links Cereblon and BET ligands to induce degradation of BET family proteins BRD2, BRD3, and BRD4 at low concentrations. It is supplied as a light yellow solid for research use only.
- Degrades BRD2, BRD3, and BRD4 at low nanomolar concentrations.
- High purity suitable for biochemical and cell-based assays.
- Readily soluble in DMSO; protocols provided for in vivo formulations.
- Stable when stored as powder at -20 °C and in solvent at -80 °C.