Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC, consisting of two ligands of von Hippel-Lindau. It dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid, and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response. This product is for research use only.
- Dimerizes von Hippel-Lindau (VHL) with high avidity in vitro.
- Induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines.
- Acts in a highly isoform-selective fashion.
- Does not trigger a hypoxic response.