Asn10,Leu11,D-Trp12-pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist that does not display any partial agonist activity. This product completely blocks the antioxidant effect of PTHrP(1-37) in mouse osteoblast MC3T3-E1 and primary human osteoblasts, confirming PTH1R activation as the main signaling mechanism for the antioxidant effect of PTHrP(1-37).
- Potent PTH-1R antagonist
- Does not display partial agonist activity
- Blocks antioxidant effect of PTHrP(1-37) in osteoblast cells
- For research use only