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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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D-I03 is a small-molecule selective RAD52 inhibitor used as a research reagent to study RAD52-dependent single-strand annealing and D-loop formation. It shows cellular activity against BRCA1- and BRCA2-deficient cells.
Selective RAD52 inhibitor with Kd 25.8 μM.
Inhibits RAD52-dependent single-strand annealing and D-loop formation.
Cellular activity: suppresses growth of BRCA1- and BRCA2-deficient cells.
Reported IC50 values: 5 μM (SSA) and 8 μM (D-loop).
Purity 99.7%.
Molecular weight 428.64 g/mol; formula C23H36N6S.
Physical state solid; color off-white to light yellow.
Solubility in DMSO 50 mg/mL.
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