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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1). This compound also inhibits dual-specificity phosphatase 26 (DUSP26).
Potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases
Exhibits IC50 values of 0.318 μM for Shp2
Exhibits IC50 values of 0.355 μM for Shp1
Inhibits dual-specificity phosphatase 26 (DUSP26)
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SIRP-beta (Sirpb CD172b) is a member of the signal-regulatory-protein (SIRP) family and also belongs to the immunoglobulin superfamily SIRP family members are receptor-type transmembrane glycoproteins Sirpb was found to interact with TYROBP/DAP12 a transmembrane adaptor protein bearing immunoreceptor tyrosine-based activation motifs resulting in the tyrosine phosphorylation of DAP12 and the subsequent recruitment of Syk to the Sirpb-DAP12 complex Sirpb is also implicated as a positive regulator of hematopoietic cells SIRP beta Protein Mouse (HEK293 His) is the recombinant mouse-derived SIRP beta protein expressed by HEK293 with C-His labeled tag
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SIRP-beta (Sirpb CD172b) is a member of the signal-regulatory-protein (SIRP) family and also belongs to the immunoglobulin superfamily SIRP family members are receptor-type transmembrane glycoproteins Sirpb was found to interact with TYROBP/DAP12 a transmembrane adaptor protein bearing immunoreceptor tyrosine-based activation motifs resulting in the tyrosine phosphorylation of DAP12 and the subsequent recruitment of Syk to the Sirpb-DAP12 complex Sirpb is also implicated as a positive regulator of hematopoietic cells SIRP beta Protein Mouse (HEK293 His) is the recombinant mouse-derived SIRP beta protein expressed by HEK293 with C-His labeled tag
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NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases, with IC50 values of 0.318 μM and 0.355 μM for Shp2 and Shp1, respectively. It also inhibits dual-specificity phosphatase 26 (DUSP26).
Potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases
Inhibits dual-specificity phosphatase 26 (DUSP26)
Inhibits DUSP26 function in NB cell lines
Results in increased p53 phosphorylation and activation
Possesses excellent anti-neuroblastoma activity in vivo
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SIRP-beta (Sirpb CD172b) is a member of the signal-regulatory-protein (SIRP) family and also belongs to the immunoglobulin superfamily SIRP family members are receptor-type transmembrane glycoproteins Sirpb was found to interact with TYROBP/DAP12 a transmembrane adaptor protein bearing immunoreceptor tyrosine-based activation motifs resulting in the tyrosine phosphorylation of DAP12 and the subsequent recruitment of Syk to the Sirpb-DAP12 complex Sirpb is also implicated as a positive regulator of hematopoietic cells SIRP beta Protein Mouse (HEK293 His) is the recombinant mouse-derived SIRP beta protein expressed by HEK293 with C-His labeled tag
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-Glucuronidase from Escherichia coli is similar to human glucuronidase enzyme and corresponds to molecular weight close to 69-71 kDa and has an pH optimum of 6.5-7.5. It belongs to family-2 glycosyl hydrolase and has active site residues glutamic acid 394 tyrosine 468 and glutamic acid 504.
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FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development cell proliferation differentiation and migration GnRH is essential for mesodermal patterning axial organization skeletogenesis and nervous system development FGFR-1 beta (IIIc) Protein Human (HEK293 His-Avi) is the recombinant human-derived FGFR-1 beta expressed by HEK293 with C-Avi C-His labeled tag
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FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development cell proliferation differentiation and migration GnRH is essential for mesodermal patterning axial organization skeletogenesis and nervous system development FGFR-1 beta (IIIc) Protein Human (HEK293 His-Avi) is the recombinant human-derived FGFR-1 beta expressed by HEK293 with C-Avi C-His labeled tag
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FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development cell proliferation differentiation and migration GnRH is essential for mesodermal patterning axial organization skeletogenesis and nervous system development FGFR-1 beta (IIIc) Protein Human (HEK293 His-Avi) is the recombinant human-derived FGFR-1 beta expressed by HEK293 with C-Avi C-His labeled tag
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PDGF R beta Protein a receptor tyrosine kinase binds ligands PDGFA PDGFB and PDGFD forming homodimers or heterodimers Ligand binding activates diverse signaling cascades in PDGF R beta with responses contingent on the specific ligand The modulation of responses involves heterodimer formation with another receptor PDGFRB PDGF R beta Protein Rat (HEK293 His) is the recombinant rat-derived PDGF R beta protein expressed by HEK293 with C-His labeled tag
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PDGF R beta Protein a receptor tyrosine kinase binds ligands PDGFA PDGFB and PDGFD forming homodimers or heterodimers Ligand binding activates diverse signaling cascades in PDGF R beta with responses contingent on the specific ligand The modulation of responses involves heterodimer formation with another receptor PDGFRB PDGF R beta Protein Rat (HEK293 His) is the recombinant rat-derived PDGF R beta protein expressed by HEK293 with C-His labeled tag
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PDGF R beta Protein a receptor tyrosine kinase binds ligands PDGFA PDGFB and PDGFD forming homodimers or heterodimers Ligand binding activates diverse signaling cascades in PDGF R beta with responses contingent on the specific ligand The modulation of responses involves heterodimer formation with another receptor PDGFRB PDGF R beta Protein Rat (HEK293 His) is the recombinant rat-derived PDGF R beta protein expressed by HEK293 with C-His labeled tag
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