Lipids and Lipid Derivatives
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 1 G
Glycocholic acid is an endogenous metabolite and a bile acid that exhibits anticancer activity by targeting both pump resistance-related and non-pump resistance-related pathways. It is suitable for research applications.
- Bile acid with anticancer activity.
- Targets pump resistance-related pathways.
- Targets non-pump resistance-related pathways.
- Increases cytotoxicity and intracellular accumulation of epirubicin in Caco-2 cells.
- Increases absorption of epirubicin in rat small intestine.
- Intensifies epirubicin-induced apoptosis.
- Downregulates MDR1, MRP1, and MRP2 mRNA expression.
- Suppresses Bcl-2 mRNA and induces Bax mRNA.
- Increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3.
- Exhibits agonist activity on TGR5 in CHO cells (EC50 = 13.6 μM).
- Inhibits E217betaG uptake in MRP4-expressing HEK293 cells (IC50 = 400 μM).
Sigma Aldrich Fine Chemicals Biosciences Prednisolone for system suitability European Pharmacopoeia (EP) Reference Standard | 50-24-8 | MFCD00003649 |
Prednisolone for system suitability European Pharmacopoeia (EP) Reference Standard | Mol Wt: 360.44 | 50-24-8 | MFCD00003649 |
Sigma Aldrich Fine Chemicals Biosciences Hydrocortisone Impurity G50MG
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Medchemexpress LLC Cortisone acetate | 50-04-4 | 98.9% | 402.48 | 10MM/1ML
Cortisone acetate (Cortisone 21-acetate) is an oxidized metabolite of Cortisol (a Glucocorticoid). It acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in the binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
- Acts as an immunosuppressant
- Acts as an anti-inflammatory agent
- Can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations
Medchemexpress LLC Hydrocortisone acepo 10mg | 74050-20-7 | 460.56 | C26H36O7 | 10 MG
Hydrocortisone aceponate (hydrocortisone 17-propionate 21-acetate) analytical standard supplied as a 10 mg package with 97% purity for research and analytical applications. It is used as a topical glucocorticoid reference standard in chromatographic and mass-spectrometric methods and in dermatoses research.
- Analytical reference standard for HPLC, GC, and MS methods.
- High purity (97%) suitable for quantitative and qualitative analysis.
- Supplied as a 10 mg package for small-scale laboratory use.
- Molecular formula C26H36O7 and molecular weight 460.56 g/mol for identification and calculations.
- Intended for research use only; not for human or veterinary administration.
Apexbio Technology LLC Dexamethasone (DHAP) 50-02-2 5g
Dexamethasone (DHAP) is a synthetic glucocorticoid commonly utilized in biomedical research due to its potent anti-inflammatory function and immunomodulatory effects It exerts its mechanism through glucocorticoid receptor-mediated transcriptional modulation resulting in reduced transcriptional activity of NF- B signaling pathways in dendritic cells (DC) thus inhibiting DC maturation and activation This compound is frequently employed in experiments investigating immune regulation inflammation and cell differentiation processes including induction of differentiation in human mesenchymal stem cells (MSCs) Additionally dexamethasone is used in cancer cell biology research as it promotes autophagy in acute lymphoblastic leukemia-derived cell lines Reported IC50 values for dexamethasone-mediated inhibition of cellular inflammation responses typically range from 2 50 nM depending on specific cellular models and experimental conditions
Medchemexpress LLC Hydrocortisone acetate | 50-03-3 | 99.1% | 1 ML
Hydrocortisone acetate is a corticosteroid used to reduce swelling, itching, and pain caused by minor skin irritations or hemorrhoids. It is intended for research use only and not for medical applications.
- Reduces swelling, itching, and pain
- Glucocorticoid receptor target
- Endogenous metabolite
- Soluble in DMSO
- Suitable for immunology and inflammation research pathways