Lipids and Lipid Derivatives
Medchemexpress LLC Prednisone acetate | 125-10-0 | 99.9% | 1 ML
Prednisone acetate is a glucocorticoid and an orally active Notch inhibitor. It exhibits anti-inflammatory activity and can enhance the immune response. For research use only; not sold to patients.
- Orally active Notch inhibitor.
- Anti-inflammatory activity.
- Can enhance the immune response.
- Reduces ocular and peripheral inflammatory responses.
- Restores Th1/Th2 and Th17/Treg immune homeostasis through orchestrating the Notch signaling pathway.
Sigma Aldrich Fine Chemicals Biosciences Prednisone Impurity J Phar50MG
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Apexbio Technology LLC Prednisone 53-03-2 10mM (in 1mL DMSO)
Prednisone is a synthetic glucocorticoid which functions primarily as an agonist of the glucocorticoid receptor (GR) Upon binding to the GR prednisone induces receptor translocation into the nucleus initiating the regulation of gene expression involved in inflammation immune responses and cellular proliferation Due to its immunosuppressive mechanism prednisone is widely used as an experimental tool in biomedical studies exploring inflammatory diseases autoimmune conditions and immune signaling pathways Structurally prednisone is a corticosteroid derivative characterized by specific modifications that affect its pharmacodynamics and bioavailability In laboratory settings prednisone assists researchers in dissecting glucocorticoid-mediated physiological and molecular events evaluating receptor-ligand interactions and examining downstream signaling mechanisms in various cell-based assays and animal models
Apexbio Technology LLC Dexamethasone (DHAP) 50-02-2 10mM (in 1mL DMSO)
Dexamethasone (DHAP) is a synthetic glucocorticoid commonly utilized in biomedical research due to its potent anti-inflammatory function and immunomodulatory effects It exerts its mechanism through glucocorticoid receptor-mediated transcriptional modulation resulting in reduced transcriptional activity of NF- B signaling pathways in dendritic cells (DC) thus inhibiting DC maturation and activation This compound is frequently employed in experiments investigating immune regulation inflammation and cell differentiation processes including induction of differentiation in human mesenchymal stem cells (MSCs) Additionally dexamethasone is used in cancer cell biology research as it promotes autophagy in acute lymphoblastic leukemia-derived cell lines Reported IC50 values for dexamethasone-mediated inhibition of cellular inflammation responses typically range from 2 50 nM depending on specific cellular models and experimental conditions
Cambridge Isotope Laboratories 6-Hydroxy-2 2 4 4 5-pentaBDE (unlabeled) 50 ug/mL in nonane 1 2 mL
6-Hydroxy-2 2 4 4 5-pentaBDE (unlabeled) 50 ug/mL in nonane 1 2 mL
![Medchemexpress LLC Glycine, N-[(3α,5β, 7α, 12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt | 863-57-0 | 487.60 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000414849.png-250.jpg)
Medchemexpress LLC Glycine, N-[(3α,5β, 7α, 12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt | 863-57-0 | 487.60 | 1 ML
Glycine, N-[(3α,5β, 7α, 12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]-, sodium salt | 863-57-0 | 487.60 | 1 ML
Cayman Chemical Glycocholic Acid-d4, Purity: ≥99% deuterated forms (d1-d4), CAS: 1201918-15-1, 5 mg
An internal standard for the quantification of glycocholic acid by GC- or LC-MS
Cayman Chemical Prostaglandin E2d4 MaxSpec S
A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
Cambridge Isotope Laboratories Sodium monofluoroacetate (unlabeled) 1 mg/mL in water 1 2 mL
Sodium monofluoroacetate (unlabeled) 1 mg/mL in water 1 2 mL
Cayman Chemical 2-bromo 17β-Estradiol, Purity: ≥98%, CAS: 15833-07-5, 10 mg
A synthetic steroid and inhibitor of estrogen 2-hydroxylase; inhibits estrogen 2-hydroxylase in rat liver microsomes at 50 and 100 µM; prevents estrogen-induced inhibition of apomorphine-induced climbing behavior in mice at 5 mg/kg
Medchemexpress LLC Estradiol 17-(β-D-glucuronide) (sodium) | 15087-02-2 | 98.9% | 25 MG
Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. It acts as a substrate for the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). This compound regulates MRP8-mediated transport processes and is suitable for studies related to intrahepatic cholestasis.
- D-ring glucuronide metabolite of natural estrogen
- Substrate for organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2)
- Regulates MRP8-mediated transport processes
- Inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid
- Induces immediate, reversible reduction of bile flow
- Suitable for studies related to intrahepatic cholestasis