Nucleosides and Analogues
Apexbio Technology LLC 8-Azido-ATP(Synonyms: 8-Azidoadenosine 5'-triphosphate, 8-N3-ATP, 8-Azido-ATP, 8-Azidoadenosine triphosphate), 50ul (100 mM).
8-Azido-ATP is a ribonucleoside triphosphate analog with an azido group substitution at the adenine C-8 position It acts primarily as an ATP mimic interacting with poly(A) polymerase (PAP) specifically illustrated using yeast poly(A) polymerase (yPAP) Incorporation of 8-azido-ATP into growing polyadenylation chains results in premature termination and moderately shorter poly(A) tails relative to natural ATP substrates Due to its chain-terminating capacity and altered substrate specificity 8-azido-ATP is applied in biochemical studies examining enzyme fidelity nucleotide selection mechanisms and RNA polymerase activity
Medchemexpress LLC Adenosine amine congener (ADAC) | 96760-69-9 | 99.2% | 1 ML
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist known for its ability to ameliorate noise- and cisplatin-induced cochlear injury. It also exhibits neuroprotective effects by reducing oxidative stress and inhibiting apoptosis in cochlear tissues, thereby protecting sensory hair cells and strial marginal cells.
- Selective A1 adenosine receptor agonist
- Ameliorates noise-induced cochlear injury
- Reduces cisplatin-induced cochlear injury
- Provides neuroprotective effects
- Reduces oxidative stress in noise-exposed cochlea
- Inhibits glutamate release via presynaptic A1 receptors
- Inhibits voltage-gated Ca2+ channels
- Prevents activation of apoptotic and necrotic cell death pathways
- Mitigates noise-induced hearing loss in a dose- and time-dependent manner
Sigma Aldrich Fine Chemicals Biosciences Guanosine 98500G
Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid intestinal cells blood-brain barrier and in brain microvessels.
SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES 2-DEOXYADENOSINE 5-TRIPHOSPH
NC3835281 2-DEOXYADENOSINE 5-TRIPHOSPH
Sigma Aldrich Fine Chemicals Biosciences Adenosine 5-triphosphate p25MG
Adenosine 5AE-triphosphate 2AE 3AE dialdehyde is a derivative of dialdehyde.
Medchemexpress LLC NAD P H-flavin reduc 20ug
NAD(P)H-flavin reductase is a recombinant His-tagged enzyme expressed in E. coli that catalyzes the reduction of soluble flavins using NADH or NADPH. Supplied as a lyophilized powder formulated in PBS with trehalose, it is intended for enzymatic assays and biochemical studies requiring a reliable flavin reductase reference reagent.
- Recombinant enzyme with N-terminal His tag.
- Catalyzes reduction of soluble flavins using NADH or NADPH.
- Supplied lyophilized from PBS with 6% trehalose.
- Purity greater than 90% by reducing SDS-PAGE.
- Low endotoxin level (<1 EU/μg).
- Stable when stored at -20°C; aliquot and freeze for long-term storage.
Sigma Aldrich Fine Chemicals Biosciences Adenosine 5'-triphosphate disodium salt hydrate Grade II, >=97% (HPLC), crystalline, from microbial | 34369-07-8 | MFCD00150755 | 500G
Adenosine 5'-triphosphate disodium salt hydrate Grade II, >=97% (HPLC), crystalline, from microbial | Purity: >=97% (HPLC) | 34369-07-8 | MFCD00150755 | 500G
Biotium MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker)(VU-4H5), CF740 conjugate, 0.1mg/mL
MAb VU-4H5 reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of MAb VU4H5 is APDTR as established with 'epitope fingerprinting'. VU-4H5 preferentially binds to under-glycosylated 'tumor' MUC1. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
TARGETMOL CHEMICALS INC ADENOSINE AMINE CONGENER 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Adenosine amine congener (ADAC) (ADAC) is an agonist of selective A1 adenosine receptor. purity: 98%
Apexbio Technology LLC Nicotinamide(Synonyms: Nicotinic acid amide, Vitamin B3 amide, Niacinamide, Pyridine-3-carboxamide, 3-Pyridinecarboxamide), 5g, CAS: 98-92-0.
Nicotinamide (CAS 98-92-0) is a small-molecule inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) an enzyme critical in DNA repair pathways Under pathological conditions such as ischemia or trauma PARP-1 hyperactivation depletes cellular NAD triggering neuronal cell death In vitro studies indicate that transporter-mediated uptake of nicotinamide confers protection against PARP-1-induced astrocyte injury In vivo studies in diabetic rat models demonstrate that nicotinamide administration normalizes hepatic antioxidant enzymes reducing oxidative stress Clinical trials have shown dose-dependent upregulation of frataxin expression following sustained nicotinamide treatment suggesting therapeutic potential in disorders like Friedreich s ataxia