Nucleosides and Analogues
Apexbio Technology LLC Adenosine Kinase Inhibitor (hydrate) 10mg
Adenosine Kinase Inhibitor (hydrate) is a small-molecule inhibitor targeting adenosine kinase It is designed to inhibit adenosine kinase thereby regulating intracellular adenosine metabolism Adenosine Kinase Inhibitor (hydrate) exerts its biological activity primarily through selective enzyme inhibition In cell-free conditions Adenosine Kinase Inhibitor (hydrate) demonstrates potent inhibitory activity with an IC50 value of approximately 1 7 nM Based on these pharmacological properties Adenosine Kinase Inhibitor (hydrate) holds research potential in investigating pain perception mechanisms and inflammation modulation through adenosine signaling pathways
Apexbio Technology LLC 8-Azido-ATP(Synonyms: 8-Azidoadenosine 5'-triphosphate, 8-N3-ATP, 8-Azido-ATP, 8-Azidoadenosine triphosphate), 10ul (100 mM).
8-Azido-ATP is a ribonucleoside triphosphate analog with an azido group substitution at the adenine C-8 position It acts primarily as an ATP mimic interacting with poly(A) polymerase (PAP) specifically illustrated using yeast poly(A) polymerase (yPAP) Incorporation of 8-azido-ATP into growing polyadenylation chains results in premature termination and moderately shorter poly(A) tails relative to natural ATP substrates Due to its chain-terminating capacity and altered substrate specificity 8-azido-ATP is applied in biochemical studies examining enzyme fidelity nucleotide selection mechanisms and RNA polymerase activity
Sigma Aldrich Fine Chemicals Biosciences Guanosine 98500G
Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid intestinal cells blood-brain barrier and in brain microvessels.
Medchemexpress LLC Adenosine 5′-diphosphoribose (sodium) | 68414-18-6 | 99.5% | 581.30 g/mol | C15H22N5NaO14P2 | 5 MG
Adenosine 5′-diphosphoribose sodium is the sodium salt form of adenosine 5′-diphosphoribose supplied as a high-purity solid for biochemical research. It is provided in small milligram pack sizes and should be stored at low temperatures to maintain stability.
- High purity (99.5%) suitable for biochemical assays.
- Sodium salt form, solid, white to light yellow.
- Molecular weight 581.30 g/mol.
- Molecular formula C15H22N5NaO14P2.
- CAS number 68414-18-6.
- Recommended storage: solid at -20°C; in solution long-term at -80°C.
Medchemexpress LLC Adenosine dialdehyde | 34240-05-6 | MFCD00056960 | >98.0% | 265.23 g/mol | C10H11N5O4 | 5MG
Adenosine dialdehyde is a purine nucleoside analogue that potently inhibits S-adenosylhomocysteine hydrolase (SAHH). It is used as a research reagent in biochemical and cellular studies to probe methylation pathways and methyltransferase activity. The compound is a crystalline solid with molecular weight 265.23 g/mol and formula C10H11N5O4, and it is soluble in DMSO.
Medchemexpress LLC Adenosine receptor inhibitor 2 | 2550401-76-6 | 99.1% | 406.28 g/mol | C17H20BrN5O2 | 10 MG
Adenosine receptor inhibitor 2 is a small-molecule research compound that acts as an adenosine receptor inhibitor with reported dual affinity for A1 and A2A receptors. It is supplied as a high-purity analytical standard intended for pharmacology and receptor-binding studies.
- High-purity small-molecule suitable for receptor pharmacology.
- Dual affinity for A1 and A2A adenosine receptors.
- Chemical formula C17H20BrN5O2, molecular weight 406.28 g/mol.
- CAS number 2550401-76-6 for substance identification.
- Available in milligram-scale packages, including 10 mg.
- Structural identifiers available (SMILES) for cheminformatics use.
- For research use only; not for human consumption or clinical use.
Selleck Chemical LLC Primaquine Diphosphate S4237-50mg
Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available displaying a marked activity against gametocytes of all species of human malaria
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
TARGETMOL CHEMICALS INC ADENOSINE AMINE CONGENER 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Adenosine amine congener (ADAC) (ADAC) is an agonist of selective A1 adenosine receptor. purity: 98%
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | MFCD16627994 | 100.0% | 681.49 g·mol^-1 | C26H32F3N3O11P2 | 10 MG
Sonidegib diphosphate is the diphosphate salt of sonidegib, a potent and selective Smoothened (Smo) antagonist used in research to inhibit Hedgehog pathway signaling. It shows low-nanomolar binding potency in Smo assays and is supplied for laboratory use with supporting datasheet and safety documents.
- Potent Smo antagonist with low-nanomolar binding (mouse 1.3 nM; human 2.5 nM).
- Diphosphate salt form suitable for aqueous assay conditions.
- Supplied as a 10 mg vial for research use.
- Molecular weight 681.49 g·mol^-1; formula C26H32F3N3O11P2.
- Storage: sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | 99.9% | 569.44 g/mol | C22H29N5O9P2 | 1 ML
Motesanib diphosphate is the diphosphate salt of motesanib (AMG 706), a potent ATP-competitive inhibitor of VEGFR1/2/3. It is supplied for research and analytical use to prepare concentrated stock solutions and for use as a reference standard in biochemical and cell-based assays.
- Research reagent for kinase inhibition assays.
- High purity, 99.9% (reported by supplier).
- CAS number 857876-30-3 and molecular weight 569.44 g/mol.
- Provided to support preparation of 1, 5, and 10 mM stock solutions.
- Common pack sizes listed for preparation include 1 mg, 5 mg, and 10 mg.