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Lenalidomide-F is an E3 ligase ligand (cereblon binder) used in targeted protein degradation research and PROTAC synthesis. It recruits cereblon to enable proteasome-dependent degradation of target proteins and is supplied as a solid research reagent for in vitro and in vivo studies.
High purity (reported ~99.4%).
Molecular weight: 262.24 g/mol.
Chemical formula: C13H11FN2O3.
Soluble in DMSO to 5 mg/mL; may require ultrasonic warming to 60°C.
Stable at room temperature for years; in solution store at -80°C or -20°C per guidance.
Available in multiple pack sizes (25 mg-1 g; larger quantities available on request).
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Itacitinib (INCB039110) is an orally active and selective inhibitor of JAK1 with an IC50 of 2 nM for human JAK1. Itacitinib shows >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis.
Orally active and selective inhibitor of JAK1
IC50 of 2 nM for human JAK1
>20-fold selectivity for JAK1 over JAK2
>100-fold selectivity for JAK1 over JAK3 and TYK2
Used in the research of myelofibrosis
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Linear Formula C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2, ≥99%, Molecular Weight 371.51, mp 97-98 °C (lit.), Synonym: (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
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Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. It inhibits the replication of HIV, shows anticancer activity in prostate cancer cell lines, can trespass the blood-brain-barrier, and suppresses telomerase activity.
Competitive, orally active nucleoside reverse transcriptase inhibitor.
Inhibits the replication of HIV.
Shows anticancer activity in prostate cancer cell lines, inhibiting cell growth, affecting cell cycle progression, inducing senescence, and modulating LINE-1 mRNA expression.
Can trespass the blood-brain-barrier.
Suppresses telomerase activity.
Significantly reduces cell migration and inhibits cell invasion.
Induces fat apoptosis.
Enhances survival of high-risk medulloblastoma-bearing mice (when administered with Decitabine).
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Also available in 1 mL, 5 mg, 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Doxazosin (UK 33274) is a long-acting alpha1-adrenoceptor inhibitor widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. Purity 99.85%
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Escitalopram is the S-enantiomer of racemic citalopram and a selective serotonin reuptake inhibitor (SSRI). This compound is provided as a research/analytical standard for preclinical pharmacology, assay development, and binding studies of serotonin transporter activity.
High selectivity for the serotonin transporter, enabling focused pharmacological studies.
Well-characterized chemical identity with CAS 128196-01-0 and formula C20H21FN2O.
Suitable for analytical standards, assay development, and quantitative studies.
Available in small analytical pack sizes appropriate for research use.
Useful for structure-activity and binding affinity experiments.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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Cyprodinil is an analytical reference standard of the anilinopyrimidine fungicide cyprodinil (CAS 121552-61-2) supplied as a white to off-white solid for research and analytical use. The material has a reported purity of 99.04%, molecular formula C14H15N3, and molecular weight 225.29 g/mol. Intended for method development, calibration, and quality control; store and handle per the certificate of analysis.
Analytical reference standard for method development and calibration.
High reported purity (99.04%) supports accurate quantitation.
Solid, white to off-white appearance for easy handling and identification.
Available in small laboratory-scale package sizes suitable for analytical workflows.
Store according to the certificate of analysis for stability and traceability.
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