Sugar acids and derivatives
Medchemexpress LLC Complement factor D-IN-2 | 1903742-34-6 | 99.33% | 574.43 | 25 MG
Complement factor D-IN-2 is an inhibitor of complement factor D, extracted from patent WO2015130838A1, compound 190. It targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway, and can be used for the research of autoimmune diseases.
- Reduces the excessive activation of complement factor D.
- Targets factor D and inhibits the complement cascade.
- Suitable for research of autoimmune diseases.
- For research use only.
Medchemexpress LLC Rehmannioside D | 81720-08-3 | MFCD30478904 | 99.9% | 686.61 g/mol | C27H42O20 | 10 MG
Rehmannioside D is a carotenoid glycoside isolated from the roots of Rehmannia glutinosa. Supplied as a 10 mg powder research reagent, it is used as an analytical standard and in biochemical studies of antioxidant activity and reactive oxygen species (ROS). Molecular formula C27H42O20; molecular weight 686.61 g/mol.
- Purity 99.9% suitable for analytical applications.
- Powder form, stable under recommended storage conditions.
- Useful in antioxidant and ROS pathway studies.
- Provided as a 10 MG vial for small-scale experiments.
- Identified by CAS number 81720-08-3 for unambiguous chemical identification.
Medchemexpress LLC D-Glucose, O-α-D-glucopyranosyl-(1→6)-O-α-D-glucopyranosyl-(1→4)- | 33401-87-5 | 99.95% | 504.44 | 25 MG
D-Panose is an oligosaccharide composed of glucose units linked by specific glycosidic bonds. It is a PAN-type oligosaccharide and a food ingredient based on isomaltooligosaccharides (IMOs). It can be detected with high sensitivity in SALDI-MS using magnesium oxide nanoparticles as the matrix.
- Composed of glucose units.
- PAN-type oligosaccharide.
- Food ingredient based on isomaltooligosaccharides (IMOs).
- High sensitivity detection in SALDI-MS.
- For research use only.
Medchemexpress LLC PROTAC BET degrader-1 | 2093386-22-0 | 99.4% | 871.90 g·mol⁻¹ | C44H45N11O9 | 25 MG
PROTAC BET Degrader-1 is a proteolysis-targeting chimera that links Cereblon and BET ligands to induce degradation of BET family proteins BRD2, BRD3, and BRD4 at low concentrations. It is supplied as a light yellow solid for research use only.
- Degrades BRD2, BRD3, and BRD4 at low nanomolar concentrations.
- High purity suitable for biochemical and cell-based assays.
- Readily soluble in DMSO; protocols provided for in vivo formulations.
- Stable when stored as powder at -20 °C and in solvent at -80 °C.
Medchemexpress LLC Integrin alpha V bet 50ug
Integrin V beta 5 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 8 Protein Human (HEK293 His solution) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 8 protein expressed by HEK293 with C-His labeled tag Integrin alpha V beta 8 Protein Human (HEK293 His solution) has molecular weight of 187 95 kDa
Medchemexpress LLC OBI-992 drug-linker | 3039487-10-7 | 96.6% | 2173.46 | 1 MG
OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. It exhibits antitumor property in mouse models and can be used for the synthesis of ADC OBI-992.
- Composed of a TOP I inhibitor and a linker
- Exhibits antitumor properties in mouse models
- Can be used for the synthesis of ADC OBI-992
Medchemexpress LLC AMG 333 | 1416799-28-4 | 99.8% | 453.32 | 25 MG
AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM. It dose-dependently inhibits wet-dog shake behavior and blocks blood pressure elevation in rat models, making it a clinical candidate for the treatment of migraine.
- Orally active and highly selective TRPM8 antagonist
- Dose-dependently inhibits wet-dog shake behavior in the Icilin-induced wet-dog shake Sprague-Dawley rat model
- Dose-dependently blocks blood pressure elevation in the cold stimulation-induced blood pressure elevation Sprague-Dawley rat model
- A clinical candidate for the treatment of migraine
Medchemexpress LLC Platycodin D | 58479-68-8 | 1225.32 | 25 MG
Platycodin D is a saponin isolated from *Platycodon grandiflorus*. It acts as an activator of AMPKα and possesses anti-obesity properties. The WNT/β-catenin pathway mediates its anti-adipogenic effect.
- Saponin isolated from *Platycodon grandiflorus*.
- Activator of AMPKα.
- Anti-obesity property.
- WNT/β-catenin pathway mediates its anti-adipogenic effect.
Alkali Scientific 4 Methylumbelliferyl β L Fucopyranoside, 100 Milligrams
Methylumbelliferyl Fucopyranoside is a high-purity reagent used in biochemical analysis to evaluate the activity of enzymes that hydrolyze fucose-containing substrates. This 100mg preparation is useful in enzyme assays aimed at studying fucosidases, which play a key role in glycosylation and glycosaminoglycan metabolism. It is commonly used in research on carbohydrate metabolism, specifically in glycosyltransferase assays and enzyme-linked tests. Methylumbelliferyl Fucopyranoside is an essential reagent for labs studying the biochemical pathways of fucose and its role in both plant and animal systems.
Medchemexpress LLC Integrin alpha 8 bet 5ug
Integrin -8/ -1 coordinates the recruitment of mesenchymal cells during renal organogenesis and recognizes RGD sequences in ligands such as TNC FN1 SPP1 TGFB1 TGFB3 and VTN It plays a role in multiple cellular interactions critical for organogenesis including NPNT as a functional ligand in nephrogenesis Integrin alpha 8 beta 1 Protein Human (HEK293 His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein expressed by HEK293 with C-His labeled tag Integrin alpha 8 beta 1 Protein Human (HEK293 His) has molecular weight of 120-140 kDa 100-120 kDa respectively
Medchemexpress LLC Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- | 838810-96-1 | 98.0% | 25 MG
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). It demonstrates strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) and functions as an antivirulence agent, effectively reversing β-lactam resistance in Methicillin-resistant strains (MRSA).
- Potent synergism with cefuroxime
- Reduces β-lactam MIC against S. aureus USA300
- Enhances activity against S. aureus clinical isolates
- Potentiates effects against various circulating MRSA strains
- Synergizes with antimicrobial peptides colistin and polymyxin B
- Inhibits mprF expression
- Inhibits citrate-induced biofilm formation
- Effective as monotherapy for MRSA-infected larvae
- Increases survival in drug-treated larvae
- Correlates with concentration-dependent bacterial killing
Medchemexpress LLC D-KLVFFA | 342877-55-8 | 99.3% | 723.90 | 10 MG
D-KLVFFA is an inhibitor of Amyloid-β assembly, with an IC50 of 2.6 μM. It can be utilized in Alzheimer's disease studies, offering insights into amyloid-beta aggregation pathways.
- Inhibits amyloid-β assembly
- Useful in Alzheimer's disease studies
- Molecular weight of 723.90
- Purity of 99.3%
Medchemexpress LLC Rose-β-D-gal | 138182-21-5 | MFCD00467206 | 99.7% | 329.73 g/mol | C14H16ClNO6 | 25 MG
Rose-β-D-Gal is a chromogenic β-galactosidase substrate that produces a pink/magenta color upon enzymatic cleavage. It is used to detect β-gal activity in biochemical and cell-based assays where a visible color change is required.
- Produces a pink/magenta chromogenic signal for β-gal activity detection.
- Suitable for enzymatic assays and staining applications.
- High reported purity (99.71%) for consistent performance.
- Solid reagent supplied in small milligram quantities for research use.
- Compatible with colorimetric readouts and microscopy.
Medchemexpress LLC Ethyl glucuronide | 17685-04-0 | 99.2% | 222.19 | 1 ML
Ethyl glucuronide is an endogenous metabolite of ethanol. It serves as a biomarker for ethanol exposure, accumulating in hair and reflecting alcohol intake over time. It is also an agonist for TLR4.
- Endogenous metabolite
- Biomarker for ethanol exposure
- Agonist for TLR4
- Appearance: Solid, white to off-white
- Storage: -20°C, protect from light, stored under nitrogen. In solvent: -80°C for 6 months; -20°C for 1 month (protect from light, stored under nitrogen).
- Useful in research for studying ethanol exposure and its effects
- Can be used to block the formation of the TLR4-MD2 complex and stimulate the expression of TLR4-dependent SEAP protein in HEK-TLR4 cells
- Has been shown to reduce tactile threshold and induce hyperalgesia in Sprague-Dawley rat models