Sugar acids and derivatives
Medchemexpress LLC UDP-glucuronic acid (trisodium) | 63700-19-6 | 99.9% | 646.23 | 10 MG
UDP-glucuronic acid trisodium (Uridine-5'-diphosphoglucuronic acid trisodium salt) is a critical precursor for essential glycoconjugates across biological kingdoms, including mammalian glycosaminoglycans, plant cell wall polysaccharides, and bacterial capsule glycoglycerolipids. This product is a laboratory chemical intended for research use only by qualified scientists.
- Precursor for essential glycoconjugates in various biological organisms
- Promotes migration of liver cancer cells (Huh7, SK-Hep1, SNU449) by inducing the EMT process in vitro
- Decreases E-cadherin levels and increases vimentin levels in Huh7 and SNU449 cells in vitro
- Soluble in H2O (≥ 100 mg/mL) and DMSO (20 mg/mL with warming/ultrasonic)
- Recommended storage at -20°C, sealed, away from moisture
- In solvent, recommended storage at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC D-Glucuronic acid lactone | 32449-92-6 | MFCD00135622 | 98.0% | 176.12 | 5 G
D-Glucuronic acid lactone is an endogenous metabolite and a glucuronic acid derivative. It serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids, synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. It also shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS).
- Endogenous metabolite and glucuronic acid derivative
- Starting reagent for the synthesis of specific glucuronic acid esters
- Prepares 1-O-acyl glucuronic acids
- Synthesizes optically active glucuronic acids
- Produces long-chain alkyl glucuronides
- Potential use in studies of reversible cerebral vasoconstriction syndrome (RCVS)
Medchemexpress LLC Tetrahydrouridine | 18771-50-1 | C9H16N2O6 | 25 MG
Tetrahydrouridine (THU) is a potent inhibitor of cytidine deaminase (CDA) that competitively blocks the enzyme's active site. It is intended for research and analytical applications, and can suppress deamination in the catabolism of cytotoxic deoxycytidine analogues.
- Potent inhibitor of cytidine deaminase (CDA)
- Competitively blocks the enzyme's active site
- Can suppress deamination in the catabolism of cytotoxic deoxycytidine analogues
- Improves Gemcitabine sensitivity in certain cell types
- Inhibits S-phase without apoptosis
- For research use only
- Analytical standard
Medchemexpress LLC Pentadecanoic acid-d29 | 130348-95-7 | MFCD00053332 | 271.58 | 10 MG
Pentadecanoic acid-d29 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone. It is for research use only.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Heparin sodium salt (MW 15kDa) | 9041-08-1 | 15000 | 500 MG
Heparin sodium salt (MW 15kDa) is a polymer of Heparin. It acts as an anticoagulant by reversibly binding to antithrombin III (ATIII), which significantly increases the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa.
- Anticoagulant properties
- Binds to antithrombin III (ATIII)
- Accelerates inactivation of thrombin factor IIa and factor Xa
Sigma Aldrich Fine Chemicals Biosciences HiPrepTM Heparin Fast Flow
HiPrep(TM) Heparin FF 16/10 is prepacked with Heparin Sepharose(R) 6 Fast FLow for preparative purification of proteins with affinity for heparin such as DNA-binding proteins coagulation factors lipoproteins and protein synthesis factors.
Medchemexpress LLC MAC-545496 | 838810-96-1 | 98.0% | 100 MG
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR), exhibiting strong binding affinity (Kd ≤ 0.1 nM). This antivirulence agent reverses β-lactam resistance in Methicillin-resistant strains (MRSA) and is intended for research use only.
- Nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR)
- Exhibits strong binding affinity to full-length GraR protein (Kd ≤ 0.1 nM)
- Reverses β-lactam resistance in MRSA strains
- Synergizes with Cefuroxime and Oxacillin against MRSA
- Inhibits mprF expression and citrate-induced biofilm formation
- Effective monotherapy for MRSA-infected Galleria mellonella larvae in vivo
Medchemexpress LLC β-D-glucopyranuronic acid methyl ester, 1,2,3,4-tetrakis(2-methylpropanoate) | 150607-94-6 | 98.1% | 488.53 g/mol | C23H36O11 | 10 MG
β-D-Glucopyranuronic acid methyl ester, 1,2,3,4-tetrakis(2-methylpropanoate) is a chemically synthesized methyl ester derivative of D-glucopyranuronic acid supplied as a high-purity research reagent for glycobiology and carbohydrate chemistry applications. It is intended for analytical use, synthesis work, and assay development in laboratory settings.
- High purity (98.1%) suitable for analytical applications.
- Chemical formula C23H36O11; molecular weight 488.53 g/mol.
- Identified by CAS number 150607-94-6 for unambiguous reference.
- Available in small package sizes, including 10 mg, for research use.
- Useful as a building block or standard in carbohydrate chemistry and glycobiology studies.
Medchemexpress LLC Protac α-synuclein degrader 5 | 2781922-42-5 | 100.0% | 767.78 g/mol | C39H41N7O10 | 10 MG
PROTAC α-synuclein degrader 5 is a small-molecule PROTAC designed to selectively target and promote degradation of α-synuclein aggregates in cellular models. Supplied as a high-purity solid for preclinical research, it shows dose-dependent activity in fibril-seeding assays and is formulated for in vitro and in vivo use.
- Selective degradation of α-synuclein aggregates (DC50 ≈ 7.5 μM, Dmax 89%).
- Demonstrated reduction of aggregates within 48 hours in PFF seeding cell models.
- High-purity solid suitable for biochemical and cellular assays.
- High solubility in DMSO for in vitro applications (≥100 mg/mL).
- Compatible with in vivo formulation protocols and frozen storage for stability.
![Medchemexpress LLC 2-((6-(4-chlorophenyl)-1-methyl-4H-triazolo[4,3-a]azepin-4-yl)methyl)-5-methyl-1,3,4-oxadiazole | 1588521-78-1 | 99.8% | 403.86 g/mol | C22H18ClN5O | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000237008.png-250.jpg)
Medchemexpress LLC 2-((6-(4-chlorophenyl)-1-methyl-4H-triazolo[4,3-a]azepin-4-yl)methyl)-5-methyl-1,3,4-oxadiazole | 1588521-78-1 | 99.8% | 403.86 g/mol | C22H18ClN5O | 10MG
BET-BAY 002 is a research-grade small-molecule BET bromodomain inhibitor used in epigenetic and oncology research. It is supplied as a white to off-white solid (CAS 1588521-78-1) with a molecular weight of 403.86 g/mol and reported high purity for reliable experimental use. The compound dissolves readily in DMSO and has recommended storage conditions for long-term stability.
Medchemexpress LLC Integrin alpha 8 bet 500ug
Integrin -8/ -1 coordinates the recruitment of mesenchymal cells during renal organogenesis and recognizes RGD sequences in ligands such as TNC FN1 SPP1 TGFB1 TGFB3 and VTN It plays a role in multiple cellular interactions critical for organogenesis including NPNT as a functional ligand in nephrogenesis Integrin alpha 8 beta 1 Protein Human (HEK293 Flag His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein expressed by HEK293 with C-10 His C-Flag labeled tag Integrin alpha 8 beta 1 Protein Human (HEK293 Flag His) has molecular weight of 85-140 kDa
Medchemexpress LLC 4-Methylumbelliferyl 10mM 1mL
4-Methylumbelliferyl octanoate is a octoate 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase[1]
BIOHIPPO T-bet-TAR-Puro LV
T-bet-TAR-Puro is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a puromycin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f