Fatty acid conjugates
Medchemexpress LLC Loxistatin acid | 76684-89-4 | 99.3% | 314.38 g/mol | C15H26N2O5 | 5 MG
E 64c (loxistatin acid) is a cysteine protease inhibitor used in research to inhibit calpain and related cysteine proteases in biochemical and cell-based assays. Supplied as a high-purity small-molecule solid, it is intended for enzymology, protease inhibition studies, and cellular investigations.
- High purity (as supplied) suitable for analytical and biological assays.
- Irreversible inhibitor of cysteine proteases including calpain.
- Solid form with good solubility in DMSO for stock solution preparation.
- Applicable to biochemical, enzymatic, and cell-based studies of protease function.
- Documentation available including data sheet and certificate of analysis.
Medchemexpress LLC Loxistatin acid | 76684-89-4 | MFCD00132882 | 99.3% | 314.38 g/mol | C15H26N2O5 | 1 ML
E 64c (loxistatin acid) is an epoxide-derived inhibitor of cysteine proteases used in biochemical and cell biology research to inhibit calpain and related enzymes. Supplied as a solid and as a ready-to-use 10 mM solution in DMSO, it supports assay setup, dose-response experiments, and inhibitor profiling.
- Epoxide-based irreversible cysteine protease inhibitor.
- Available as solid or 10 mM solution in DMSO for experimental flexibility.
- High purity, suitable for sensitive biochemical assays (>99%).
- High DMSO solubility for preparation of concentrated stock solutions.
- Useful for calpain and general cysteine protease inhibition studies.
Medchemexpress LLC Loxistatin acid (E-64c) | 76684-89-4 | 99.3% | 314.38 | C15H26N2O5 | 25 MG
E 64c (Loxistatin acid) is an irreversible inhibitor of cysteine proteases derived from the natural epoxide E-64. It is intended for research use in biochemical and enzymology assays to study calpain and other cysteine proteases. The material is supplied as a high-purity white to off-white solid and is available in multiple package sizes and preprepared DMSO solution formats for immediate use in assays.
- Irreversible cysteine protease inhibitor
- High purity (99.32%)
- Molecular weight 314.38 g·mol⁻1
- Available as solid and as 10 mM solution in DMSO
- Suitable for calpain and protease inhibition assays
- Storage conditions provided for powder and solvent formats
Medchemexpress LLC Loxistatin acid (E 64c) | 76684-89-4 | 99.3% | 314.38 g/mol | C15H26N2O5 | 1 MG
E 64c (Loxistatin acid) is an epoxide-derived irreversible inhibitor of cysteine proteases that primarily inhibits calpain and shows weak irreversible inhibition of cathepsin C. Supplied as a high-purity solid for research use, it is used in biochemical and cellular studies of protease activity and has been reported to exhibit entry-blocking activity against MERS-CoV.
- Irreversible cysteine protease inhibitor targeting calpain.
- High purity suitable for research applications.
- Available in small solid sizes for assay flexibility.
- Reported to exhibit entry-blocking activity against MERS-CoV.
- Stable solid form for convenient storage and handling.
AdipoGen Itaconic acid 4-octyl ester
Chemical. CAS 3133-16-2. Formula C13H22O4. MW 242.3. Derivative of itaconate AG-CN2-0426 https//adipogen.com/ag-cn2-0426-itaconic-acid.html with enhanced cell permeability. Prodrug that is efficiently metabolized to itaconate in cells. Potent anti-inflammatory agent. In vitro it activates the transcription factor nuclear factor erythroid 2-related factor 2 Nrf2 also known as NFE2L2 in LPS-induced mouse and human macrophages. Upregulates Nrf2 levels via a newly identified post-translational modification, dicarboxylation of KEAP1. Alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream gene. Cysteine 151 is uniquely required for inhibiting KEAP1-mediated degradation of Nrf2 and mutating this residue in KEAP1 prevents the stabilization of Nrf2.
Medchemexpress LLC Loxistatin acid (E-64c) | 76684-89-4 | MFCD00132882 | 99.3% | 314.38 g/mol | C15H26N2O5 | 10 MG
Loxistatin acid (E-64c) is an irreversible epoxide-based inhibitor of cysteine proteases used as a research reagent to probe protease-dependent biological processes. It is a membrane-permeant derivative of the natural epoxide inhibitor E-64, with reported activity against papain-like enzymes, cathepsins, and calcium-activated neutral protease; it has also shown entry-blocking effects in MERS-CoV studies.
- Irreversible epoxide inhibitor of cysteine proteases.
- Membrane-permeant chemistry suitable for cell-based assays.
- Reported activity against papain, cathepsins, and CANP.
- High purity for reproducible experimental results.
- Recommended storage preserves stability for long-term use.
AdipoGen Itaconic acid 4-octyl ester
Chemical. CAS 3133-16-2. Formula C13H22O4. MW 242.3. Derivative of itaconate AG-CN2-0426 https//adipogen.com/ag-cn2-0426-itaconic-acid.html with enhanced cell permeability. Prodrug that is efficiently metabolized to itaconate in cells. Potent anti-inflammatory agent. In vitro it activates the transcription factor nuclear factor erythroid 2-related factor 2 Nrf2 also known as NFE2L2 in LPS-induced mouse and human macrophages. Upregulates Nrf2 levels via a newly identified post-translational modification, dicarboxylation of KEAP1. Alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream gene. Cysteine 151 is uniquely required for inhibiting KEAP1-mediated degradation of Nrf2 and mutating this residue in KEAP1 prevents the stabilization of Nrf2.
Cayman Chemical 5 8 11-EIcosatrIynoIc AcId 1mg
5,8,11-ETI is a nonselective inhibitor of lipoxygenases. It inhibits 12-LO in human platelets with an ID50 value of 24 µM.{66} 5,8,11-ETI also inhibits A23187 and L-cysteine induced LTC4 biosynthesis in mouse mastocytoma cells with an ID50 value of 5 µM.{650} At higher concentrations, 5,8,11-ETI also inhibits cyclooxygenases (ID50 = 340 µM).{66}