Sphingolipids
Medchemexpress LLC C16 ceramide (N-palmitoylsphingosine, D-erythro) | 24696-26-2 | MFCD00056205 | 98.0% | 537.90 | C34H67NO3 | 25 MG
C16 ceramide is a naturally occurring sphingolipid (N-palmitoylsphingosine) used as a research reagent that activates p53 through direct, selective binding. Supplied as a white to off-white solid, it is used in cell biology studies of apoptosis, cell signaling, and mitochondrial membrane permeability. Store protected from light at 4°C; in solution store at -80°C (long term) or -20°C (short term).
- Activates p53 through direct, selective binding.
- Endogenous sphingolipid for studies of apoptosis and cell signaling.
- Supplied as a stable solid, white to off-white in color.
- Compatible with common organic solvents; prepare fresh solutions and protect from light.
- Intended for research use only.
Medchemexpress LLC Ceramide 3B | 178436-06-1 | 99.6% | 581.95 | 50 MG
Ceramide 3B is a ceramide 3 lipid class that exhibits aggregation behavior. It possesses various physiological functions, serving as a penetration enhancer and auxiliary emulsifier, and contributes significantly to barrier function stability.
- Ceramide 3 lipid class with aggregation behavior.
- Variety of physiological functions.
- Can serve as a penetration enhancer.
- Functions as an auxiliary emulsifier.
- Plays an important role in barrier function stability.
Sigma Aldrich Fine Chemicals Biosciences Colorimetric Sphingomyelin
Sphingomyelinase (SMase) or sphingomyelin phosphodiesterase catalyzes the hydrolytic cleavage of sphingolipid to phosphocholine and ceramide a second messenger involved in multiple cellular responses including the cellular response to stress. There are at least 5 types of SMases identified which are classified according to their cation dependence cellular location and pH optima for activity and include the acidic and neutral sphingomyelinase. Neutral SMases along with the acidic SMases are thought to be major contributors to the production of ceramide in response to cellular stress.
Cayman Chemical C12 NBD Ceramide (d18:1/12:0), Purity: ≥98%, CAS: 202850-01-9, 5 mg
C12 NBD ceramide (d18:1/12:0) is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity.{14063} It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral ceramidases from a variety of mammalian cell lines also hydrolyze C12 NBD ceramide (d18:1/12:0). Acid ceramidase does not appear to utilize C12 NBD ceramide (d18:1/12:0) as a substrate. The possibility exists forC12 NBD ceramide (d18:1/12:0) to also be applied to the measurement of ceramide kinase and/or sphingomyelin synthase activity.
Medchemexpress LLC C18:1-Ceramide | 5966-28-9 | 99.9% | C36H69NO3 | 50 MG
C18:1-Ceramide is a ceramide subspecies primarily used for research and analytical applications. It serves as an analytical standard and can be utilized in studies related to type 2 diabetes.
- Ceramide subspecies
- Intended for research and analytical applications
- Can be used in the study of type 2 diabetes
Cayman Chemical Sphinganine (d18:0), Purity: ≥95%, CAS: 764-22-7, 50 mg
A precursor of ceramide and sphingosine; can emulate S1P in cell signaling or have opposite intracellular effects
Cambridge Isotope Laboratories Lyso-PC 26 0 (unlabeled) CP 95% 0 01 g
Lyso-PC 26 0 (unlabeled) CP 95% 0 01 g
Medchemexpress LLC DMTr-2'-O-C22-rC-3'-CE-Phosphoramidite | 2923115-93-7 | 98.0% | 1096.42 | 1 ML
DMTr-2'-O-C22-rC-3'-CE-Phosphoramidite (Compound 114) is a phosphoramidite that can be used for the synthesis of oligonucleotides. It is for research use only and not sold to patients.
- Used for the synthesis of oligonucleotide.
- For research use only.
Medchemexpress LLC DHA Ceramide (C22:6 Ceramide) | 218608-43-6 | 98.7% | 609.96 | 1 ML
DHA Ceramide (C22:6 Ceramide) is a solid, light yellow to yellow compound with a purity of 98.65%. It has a molecular weight of 609.96 and a chemical formula of C40H67NO3. This product is intended for research purposes only.
- Appearance: Solid, light yellow to yellow
- Purity: 98.65%
- Storage (solid): -20°C, protect from light, stored under nitrogen
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month; protect from light, stored under nitrogen
- Solubility: 100 mg/mL in DMSO (requires ultrasonic)
Cayman Chemical C6 NBD dihydro Ceramide (d18:0/6:0), Purity: ≥98%, CAS: 114301-97-2, 10 mg
Structurally identical to C6 NBD ceramide, but contains a saturated bond in the C-4/C-5 position of the sphingosine backbone
Medchemexpress LLC C8 PEG750 ceramide | 212116-76-2 | 99.9% | 750.0 g/mol (average) | (C2H4O)nC31H57NO6 | 5 MG
C8 PEG750 ceramide is a PEGylated ceramide lipid used to form lipid bilayer carriers such as liposomes and lipid nanoparticles for selective delivery of diagnostic and therapeutic agents to acidic diseased cells. It is provided as a high-purity research reagent suitable for formulation development and analytical studies.
- High purity for reliable formulation and analysis.
- PEGylated ceramide structure for steric stabilization of lipid assemblies.
- Average molecular weight ~750 supports PEG shielding properties.
- Suitable for liposome and LNP formulation development.
- Available in small milligram pack sizes for research use.
Cayman Chemical Sphinganine (d18:0), Purity: ≥95%, CAS: 764-22-7, 5 mg
A precursor of ceramide and sphingosine; can emulate S1P in cell signaling or have opposite intracellular effects
Medchemexpress LLC 7-(4-(2-((1,3-Dihydroxyoctadec-4-en-2-yl)amino)-2-oxoethoxy)phenyl)-5,5-difluoro-3-(thiophen-2-yl)-5 | 571186-05-5 | 99.17% | 705.70 | 250 UG
The Golgi apparatus consists of flattened vesicles stacked together, which are round with expanded and perforated edges. BODIPY TR Ceramide is a BODIPY-labeled ceramide derivative that functions as a Golgi-specific fluorescent dye. It is synthesized in the endoplasmic reticulum and subsequently transported to the Golgi apparatus through ceramide transport protein (CERT) or vesicular translocation, enabling specific labeling. This dye allows for the visualization of individual cells with an excitation/emission (Ex/Em) of 589 nm/616 nm.
- Golgi-specific fluorescent dye
- Can visualize individual cells
- Excitation/emission (Ex/Em) = 589 nm/616 nm
Medchemexpress LLC 17:1 lyso pc | 1246304-62-0 | 98.0% | 507.64 | C25H50NO7P | 10 MG
17:1 Lyso PC is a lysophosphatidylcholine lipid used to simulate biological phospholipid membranes and to formulate liposomes for drug delivery research. It forms vesicles with concentric phospholipid bilayers, enabling encapsulation of polar, water-soluble payloads in the internal aqueous space and incorporation of lipophilic payloads within the lipid layer. It is commonly used in studies of anticancer, anti-infection, and nucleic-acid delivery.
- Molecular formula: C25H50NO7P.
- Molecular weight: 507.64.
- Purity: 98.0%.
- CAS number: 1246304-62-0.
- Appearance: white to off-white solid-liquid mixture.
- Storage: -20°C (pure form, long term); -80°C (in solvent, short term).
- Pack size: 10 mg.
- Typical applications: liposome formulation and nucleic-acid delivery research.