Steroids and derivatives
Medchemexpress LLC 9-cis-Retinol acetate | 29584-22-3 | 85.0% | 328.49 | 10 MG
9-cis-Retinol acetate is a retinal derivative, also known as 9-cis-Vitamin A acetate or Zuretinol acetate. It is provided as a white to off-white solid and is intended for research use only, not for use with patients.
- Molecular weight: 328.49
- Formula: C22H32O2
- Purity: 85.0%
- Storage for powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Bazedoxifene acetate | 198481-33-3 | MFCD09260074 | 99% | C32H38N2O5 | 100 MG
Bazedoxifene acetate, also known as TSE-424 (acetate)-B, is the B-crystal form compound of Bazedoxifene acetate. It functions as an orally active, nonsteroidal selective estrogen receptor modulator (SERM). This product is intended for research use only.
- Orally active, nonsteroidal selective estrogen receptor modulator (SERM)
- IC50s of 23 nM for ERα and 99 nM for ERβ
- Ships at room temperature
- Store at 4°C, sealed, away from moisture and light
- In solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at 50 mg/mL
Selleck Chemical LLC Paricalcitol-1mg
Paricalcitol (Paracalcin, Zemplar, 19-Nor-1-25-OH2D2, 19-Nor-colecalciferol) is a selective vitamin D receptor agonist. Paricalcitol suppresses parathyroid hormone mRNA expression and inhibits parathyroid cell proliferation. Pariccitol is used to treat secondary hyperparathyroidism in chronic kidney disease.
Medchemexpress LLC Estrone sulfate (sodium) | 438-67-5 | 99.8% | 372.41 | 25 MG
Estrone sulfate sodium is an inactive endogenous estrogen. It can be converted into Estrone and Estradiol and is a substrate of the OATP1B3 transporter. This compound stimulates the growth of nitrosomethylurea-induced mammary tumors and colony formation of dispersed nitrosomethylurea mammary cells, with conversion to Estrone and Estradiol occurring both in vivo and in vitro.
- Can be converted into Estrone and Estradiol.
- Substrate of the OATP1B3 transporter.
- Stimulates mammary tumor growth in ovariectomized rats.
- Applicable to breast cancer-related research.
Medchemexpress LLC Octaarginine acetate | 98.3% | 1267.50 | 5 MG
Octaarginine acetate is a cell-penetrating peptide and proteasome inhibitor. It exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. It induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, and enhances liposomal cargo uptake and gene delivery. Octaarginine acetate can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections.
- Potently inhibits chymotrypsin-like and caspase-like activities of 20S proteasomes.
- Efficiently delivers protein, peptide, and plasmid DNA cargos into cultured cells.
- Inhibits the growth of E. coli and S. aureus bacterial cells.
- Inhibits HeLa human cancer cell growth in a concentration-dependent manner.
Medchemexpress LLC Estrone 3-methyl ether | 1624-62-0 | 97.38% | C19H24O2 | 5 MG
Estrone 3-methyl ether is a synthetic intermediate used in the synthesis of estrogen receptor modulators.
- Used in the synthesis of estrogen receptor modulators
- Molecular weight: 284.39
- Molecular formula: C19H24O2
- CAS number: 1624-62-0
- Purity: 97.38%
- Appearance: Solid, white to off-white
- Storage (Powder): -20°C for 3 years; 4°C for 2 years
- Storage (In solvent): -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Talfirastide acetate | 2855063-75-9 | 99.77% | 959.06 | 10 MG
Talfirastide acetate | 2855063-75-9 | 99.77% | 959.06 | 10 MG
Medchemexpress LLC Melatonin-d3 (N-acetyl-5-methoxytryptamine-d3) | 90735-69-6 | 99.2% | C13H13D3N2O2 | 1 MG
Melatonin-d3 is a deuterium-labeled form of Melatonin, a hormone produced by the pineal gland. Melatonin activates melatonin receptors and is known for its role in sleep, as well as its significant antioxidative and anti-inflammatory properties. It has been identified as a novel selective ATF-6 inhibitor and can induce apoptosis in human hepatoma cells by downregulating COX-2. Additionally, Melatonin has been shown to attenuate palmitic acid-induced mouse granulosa cell apoptosis through endoplasmic reticulum stress.
- Deuterium labeled
- Tracer
- Internal standard for quantitative analysis
- Pharmacokinetic studies
Medchemexpress LLC 17β-estradiol sulfate sodium | 4999-79-5 | MFCD00056553 | 99.0% | 374.43 g·mol⁻¹ | C18H23NaO5S | 5 MG
17β-estradiol sulfate sodium is the sodium salt of the sulfate metabolite of 17β-estradiol supplied as a solid research reagent. It is used for studies of estrogen metabolism, receptor binding, and neuroactive steroid activity. For research use only; not for human or veterinary use.
- Sodium salt of 17β-estradiol sulfate.
- High purity (99.0%).
- Molecular weight 374.43 g·mol⁻¹.
- Chemical formula C18H23NaO5S.
- Provided as a white to light yellow solid.
- SDS and COA available for quality and safety documentation.
Medchemexpress LLC Rufinamide-d2 | 1129491-38-8 | C10H6D2F2N4O | 1 MG
Rufinamide-d2 (CGP 33101-d2) is a deuterium-labeled Rufinamide, an orally active antiepileptic compound. It inhibits Na+ current activation and neuronal hyperexcitability, exhibiting anticonvulsant effects. This compound is utilized in the study of Lennox-Gastaut syndrome, with its deuteration influencing pharmacokinetic and metabolic profiles.
- Inhibits Na+ current activation
- Inhibits neuronal hyperexcitability
- Provides anticonvulsant effects
- Used in the study of Lennox-Gastaut syndrome
- Deuterium-labeled for tracer applications
- Influences pharmacokinetic and metabolic profiles