Steroids and derivatives
Apexbio Technology LLC HYDROCORTISONE 1G
Hydrocortisone (CAS 50-23-7) is an endogenous glucocorticoid primarily synthesized and secreted by the adrenal cortex It exerts biological effects by binding glucocorticoid receptors altering gene expression involved in metabolic regulation immune response modulation and anti-inflammatory pathways Widely utilized in biomedical research hydrocortisone serves as a standard reference agent for investigating glucocorticoid receptor signaling inflammation models and stress response mechanisms
Apexbio Technology LLC VITAMIN D3 5G
Vitamin D3 (Cholecalciferol CAS 67-97-0) is an endogenous fat-soluble vitamin that serves as a precursor requiring metabolic conversion to its biologically active metabolite Following hydroxylation the active form exerts its function predominantly by binding the nuclear vitamin D receptor (VDR) modulating gene expression pathways involved in cellular differentiation and proliferation Research indicates that activated Cholecalciferol promotes cellular differentiation and exhibits anti-proliferative effects against various cancer cell types Consequently Vitamin D3 is frequently utilized in biomedical research studying mechanisms underlying tumor development and differentiation pathways
Apexbio Technology LLC Prednisone 53-03-2 10mM (in 1mL DMSO)
Prednisone is a synthetic glucocorticoid which functions primarily as an agonist of the glucocorticoid receptor (GR) Upon binding to the GR prednisone induces receptor translocation into the nucleus initiating the regulation of gene expression involved in inflammation immune responses and cellular proliferation Due to its immunosuppressive mechanism prednisone is widely used as an experimental tool in biomedical studies exploring inflammatory diseases autoimmune conditions and immune signaling pathways Structurally prednisone is a corticosteroid derivative characterized by specific modifications that affect its pharmacodynamics and bioavailability In laboratory settings prednisone assists researchers in dissecting glucocorticoid-mediated physiological and molecular events evaluating receptor-ligand interactions and examining downstream signaling mechanisms in various cell-based assays and animal models
Apexbio Technology LLC HYDROCORTISONE 1ML
Hydrocortisone (CAS 50-23-7) is an endogenous glucocorticoid primarily synthesized and secreted by the adrenal cortex It exerts biological effects by binding glucocorticoid receptors altering gene expression involved in metabolic regulation immune response modulation and anti-inflammatory pathways Widely utilized in biomedical research hydrocortisone serves as a standard reference agent for investigating glucocorticoid receptor signaling inflammation models and stress response mechanisms
Selleck Chemical LLC Dexamethasone palmitate S5184-25mg
Dexamethasone palmitate (DXP) a lipophilic prodrug of Dexamethasone (DXM) is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity
Cayman Chemical 2-bromo 17-EstradIol 10mg
An internal standard for the quantification of epinephrine by GC- or LC-MS
Cayman Chemical EstradIol 3 DGlucuronIde 25mg
A peptide inhibitor of NFAT binds to the NFAT recognition site on calcineurin (IC50 25 pM) but does not inhibit calcineurin phosphatase activity at 100 UM inhibits the dephosphorylation of NFAT in HEK293T lysates expressing NFAT1 -2 or -4 inhibits NFAT activation in RAW 264.7 macrophages EA.hy926 endothelial cells and isolated mouse thoracic aorta VSMCs (IC50s 29.1 30.2 and 45.7 UM respectively in reporter assays)
Cayman Chemical 25-hydroxy VItamIn D3 10mg
A lysophospholipid increases cAMP production in human pancreatic B cells an effect that can be blocked by the GPR55 antagonist CID-16020046 or the GPR119 antagonist C8 increases glucose-stimulated insulin secretion in the same cell type an effect that can be reduced by CID-16020046 or C8
U.S. Pharmacopeia prednisolone | 50-24-8 | 360.4 g/mol | 200MG
prednisolone | 50-24-8 | 360.4 g/mol | 200MG
Medchemexpress LLC UCL-TRO-1938 5MG
UCL-TRO-1938 is a potent allosteric activator of PI3Kα with an EC50 value of approximately 60 μM. UCL-TRO-1938 can induce cell proliferation and has cardioprotective and neural regeneration effects.