Steroids and derivatives
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 25 MG
Glycocholic acid is a bile acid with demonstrated anticancer activity. It targets both pump resistance-related and non-pump resistance-related pathways. It increases the cytotoxicity of epirubicin, enhances its intracellular accumulation, and improves its absorption, intensifying epirubicin-induced apoptosis. Combining it with anticancer drugs can help control multidrug resistance by modulating P-gp and MRPs, and by regulating apoptosis-related pathways.
- Increases cytotoxicity of epirubicin
- Enhances intracellular accumulation of epirubicin
- Improves absorption of epirubicin in rat small intestine
- Intensifies epirubicin-induced apoptosis
- Reduces mRNA expression of MDR1, MRP1, and MRP2
- Downregulates MDR1 promoter region
- Suppresses Bcl-2 mRNA expression
- Induces Bax mRNA expression
- Increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9, and -3
Selleck Chemical LLC Estradiol Cypionate S4046-50mg
Estradiol cypionate is the 17 -cyclopentylpropinate ester of estradiol which inhibits ET-1 synthesis via estrogen receptor
Cambridge Isotope Laboratories 6-Hydroxy-2 2 4 4 5-pentaBDE (unlabeled) 50 ug/mL in nonane 1 2 mL
6-Hydroxy-2 2 4 4 5-pentaBDE (unlabeled) 50 ug/mL in nonane 1 2 mL
Medchemexpress LLC Ofloxacin-d3 | 1173147-91-5 | 99.8% | 1 MG
Ofloxacin-d3 is a deuterium-labeled form of Ofloxacin designed for research applications. It serves as a tracer and an internal standard, facilitating quantitative analysis in methods like NMR, GC-MS, or LC-MS. This compound leverages stable heavy isotopes, which are incorporated into drug molecules to aid quantitation during drug development and may influence pharmacokinetic and metabolic profiles.
- Deuterium labeled Ofloxacin.
- Intended for research use only.
- Functions as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes into drug molecules.
- Potential to affect pharmacokinetic and metabolic profiles of drugs.
eMolecules 79037-37-9 | Medchem Express | Estradiol-d3 | 1mg | 713707131 | HY-B0141S | MFCD01074033 | 275.406 | C18H24O2
Medchem Express | Estradiol-d3 | 1mg | 713707131 | HY-B0141S | 79037-37-9 | MFCD01074033 | 275.406 | C18H24O2
Medchemexpress LLC Hydrocortisone phosphate sodium | 6000-74-4 | MFCD00152562 | 99.1% | 486.40 g·mol⁻¹ | C21H29Na2O8P | 50 MG
Hydrocortisone phosphate sodium is the disodium phosphate salt of hydrocortisone, a water-soluble corticosteroid used as a research reagent. It has corticosteroid activity with relatively low anti-inflammatory potency and a short duration of action, and is used in biochemical and pharmacological studies, including research on ocular conditions and gastric ulcers.
- Water-soluble sodium phosphate salt suitable for aqueous formulations.
- Useful for biochemical and pharmacological research of corticosteroid activity.
- Relatively low anti-inflammatory potency with short duration of action.
- High purity and defined molecular weight for reproducible results.
- Stable when stored sealed and away from moisture; follow cold storage recommendations for solutions.
Medchemexpress LLC Cyclin D2/CCND2 antibody (YA789) | Affinity purified | Predicted band size: 33 kDa; Observed band size: 38 kDa | 10 UL
Cyclin D2/CCND2 antibody (YA789) is a mouse-derived, non-conjugated IgG2b monoclonal antibody targeting Cyclin D2/CCND2. It is formulated in 1x PBS (pH 7.3), 50% glycerol, and 0.5% BSA, containing 0.02% sodium azide as a preservative. This antibody is intended for research use only and reacts with human species.
- Host: Mouse
- Clonality: Monoclonal
- Isotype: IgG2b
- Species reactivity: Human
- Purity: Affinity purified
- Applications: Western Blot (WB)
- Immunogen: Synthetic peptide corresponding to human Cyclin D2
- Storage: Store at -20°C for 1 year, avoid repeated freeze/thaw cycles
Medchemexpress LLC Verapamil-d3 hydrochloride | 2714485-49-9 | 99.57% | C27H36D3ClN2O4 | 5 MG
Verapamil-d3 hydrochloride is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride is a calcium channel blocker and a potent, orally active first-generation P-glycoprotein (P-gp) inhibitor. It also inhibits CYP3A4 and has potential for research into high blood pressure, heart arrhythmias, and angina.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs