Steroids and derivatives
Apexbio Technology LLC 17-Hydroxyprogesterone 68-96-2 50mg
17-Hydroxyprogesterone (68-96-2) is a small-molecule agonist targeting the progesterone receptor (PR) with partial agonist activity at glucocorticoid receptors (GR) and antagonist effects at mineralocorticoid receptors (MR) It modulates steroid hormone signaling pathways thereby influencing vascular tone and inflammation 17-Hydroxyprogesterone exerts its biological activity primarily through activation and modulation of steroid hormone receptors In animal models administration of 17-Hydroxyprogesterone demonstrates the ability to modulate vascular inflammation and uterine vascular tone Based on these pharmacological properties 17-Hydroxyprogesterone holds research potential in the screening of congenital adrenal hyperplasia and related metabolic syndromes as well as associations with respiratory distress syndrome and premature birth outcomes
TARGETMOL CHEMICALS INC 7alpha-Hydroxy-4-cholesten
Also available in 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. 7alpha-Hydroxy-4-cholesten-3-one is an intermediate in bile acid synthesis from cholesterol, a PXR agonist, and a biomarker for bile acid loss and diseases related to defective bile acid biosynthesis. It is also the physiological substrate for [CYP8B1]. Purity 99.14%
Cayman Chemical ResIbufogenIn 1mg
A cardiac glycoside that inhibits the Na+/K+-ATPase; exhibits cardiotonic, vasopressor, and respiratory stimulating actions in both animal and clinical models
Medchemexpress LLC N-Caproicacid-d3 so 10mg
N-caproicacidsodiumsalt-d3 is the deuterium labeled N-caproicacidsodiumsalt[1]
Medchemexpress LLC Melatonin-d3 (N-Acetyl-5-methoxytryptamine-d3) | 90735-69-6 | 99.1% | C13H13D3N2O2 | 5 MG
Melatonin-d3 is the deuterium labeled version of Melatonin. Melatonin is a hormone that activates melatonin receptors, playing a role in sleep and possessing antioxidative and anti-inflammatory properties. It is also identified as a selective ATF-6 inhibitor, inducing apoptosis in human hepatoma cells by downregulating COX-2, and can reduce palmitic acid-induced apoptosis in mouse granulosa cells by alleviating endoplasmic reticulum stress.
- Used as a tracer
- Serves as an internal standard for quantitative analysis
- Stable heavy isotopes for drug development quantitation
- Deuteration can influence pharmacokinetic and metabolic profiles
- Powder storage: -20°C for 3 years, 4°C for 2 years
- Solvent storage: -80°C for 6 months, -20°C for 1 month
TARGETMOL CHEMICALS INC Deapi-platycodin D3 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Deapi-platycodin D3 is a natural product isolate from the root of Platycodon grandiflorum. Purity 98.11%
Medchemexpress LLC Ergocalciferol | 50-14-6 | >99.1% | 396.65 | 5 G
Vitamin D2 (Ergocalciferol) is a form of Vitamin D derived from plant sources or dietary supplements. It is used as a supplement of Vitamin D. This product is intended for research use only.
- Derived from plant sources or dietary supplements
- Activator of Vitamin D receptor
- Used as a supplement of Vitamin D
- Intended for research use
Medchemexpress LLC Pefloxacin-d3 | 2733455-58-6 | 99.4% | 5 MG
Pefloxacin-d3 (Pefloxacinium-d3) is a deuterium-labeled version of the broad-spectrum antibiotic Pefloxacin. It blocks DNA replication by inhibiting DNA gyrase and also inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. This compound demonstrates antibacterial activity against various bacteria such as *Escherichia coli*, *Pseudomonas aeruginosa*, and *Bacteroides fragilis*.
- Deuterium labeled version of Pefloxacin
- Broad-spectrum antibiotic
- Inhibits DNA gyrase, blocking DNA replication
- Inhibits DNA relaxation catalyzed by topoisomerase I
- Exhibits antibacterial activity against *Escherichia coli*, *Pseudomonas aeruginosa*, and *Bacteroides fragilis*
- Shows anti-*Plasmodium yoelii* infection activity
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC 3-epi-Vitamin D3 (Epicholecalciferol) | 57651-82-8 | C27H44O | 25 MG
3-epi-Vitamin D3 (Epicholecalciferol) is a Vitamin D3 analogue. It acts as a Hedgehog pathway inhibitor with an IC50 of 39.2 μM in U87MG cells and significantly upregulates Cyp24A1 in U87MG, HT-29, and C3H10T1/2 cells.
- Acts as a Hedgehog pathway inhibitor
- Upregulates Cyp24A1 in U87MG, HT-29, and C3H10T1/2 cells
- Appears as a white to light yellow solid
Medchemexpress LLC Vitamin D3 (Standard) | 67-97-0 | C27H44O | 25 MG
Vitamin D3 (Standard) is the analytical standard of Vitamin D3, intended for research and analytical applications. This naturally occurring form of vitamin D induces cell differentiation and prevents the proliferation of cancer cells. It serves as a reference standard for qualitative, quantitative, and methodological research experiments, including HPLC, GC, and MS.
- Induces cell differentiation
- Prevents proliferation of cancer cells
- Used as a reference standard in qualitative, quantitative, and methodological research experiments (HPLC, GC, MS)
[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCC[N+](C)(C)CCO | 5mg | 779524216](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502467827.JPG-250.jpg)
eMolecules 794494-38-5 | DMHAPC-Chol | Broadpharm559.899 | C35H63N2O3 | 0.000 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCC[N+](C)(C)CCO | 5mg | 779524216
DMHAPC-Chol | Broadpharm | 794494-38-5559.899 | C35H63N2O3 | 0.000 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCC[N+](C)(C)CCO | 5mg | 779524216
Medchemexpress LLC N-(1-phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine | 662164-09-2 | MFCD04077665 | 99.5% | 333.43 g/mol | C20H23N5 | 50MG
D3-βArr (N-(1-phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine; CAS 662164-09-2) is a small-molecule thyroid-stimulating-hormone (TSH) receptor modulator supplied as a high-purity solid for research use. It is provided in laboratory-scale quantities suitable for biochemical and cellular assays investigating TSH receptor pharmacology.
- High reported purity (99.5%).
- Solid form, white to off-white, suitable for standard storage.
- Molecular weight 333.43 g/mol and formula C20H23N5.
- Supplied in a 50 mg laboratory-scale quantity.
- Intended for research use only; not for human or clinical use.
- Suitable for biochemical and cellular assays targeting TSH receptor activity.