Steroids and derivatives
Apexbio Technology LLC CEFPODOXIME-D3-1MG
Cefpodoxime-d3 (CAS No 2477791-28-7) is a deuterated version of the third-generation cephalosporin antibiotic cefpodoxime used primarily in biomedical research to study its pharmacokinetics and metabolic pathways Originating from modifications of the standard cefpodoxime molecule it retains similar antibacterial activity by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins effectively disrupting cell wall biosynthesis Typically exhibiting in vitro activity in the nanomolar to low micromolar range it is employed in various experimental setups including cell models and animal studies to investigate its efficacy and safety profile This compound is also pertinent in drug screening scenarios where detailed metabolic and pharmacokinetic data are required Experimental concentrations typically depend on the specific research design allowing flexibility for various investigative frameworks
Medchemexpress LLC N-(1-phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine | 662164-09-2 | MFCD04077665 | 99.5% | 333.43 | C20H23N5 | 10MM 1ML
D3-βArr is a small-molecule positive allosteric modulator of the thyrotropin receptor intended for research use. It is supplied as a solid and as a 10 mM solution in DMSO, and is used in receptor pharmacology and functional assays to study β-arrestin translocation and TSHR signaling.
- Positive allosteric modulator of the thyrotropin receptor (TSHR).
- Supports beta-arrestin translocation and TSHR functional assays.
- High purity (reported ~99.5%).
- Available as solid (multiple mg sizes) and 10 mM solution in DMSO.
- Molecular formula C20H23N5, molecular weight 333.43.
Medchemexpress LLC (S)-N-((3-Methyl-1-(methyl-d3)-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide | 2216712-66-0 | 99.23% | 600.67 | 500 UG
Elexacaftor-d3 (VX-445-d3) is the deuterium labeled form of Elexacaftor, designed as a tracer and internal standard for quantitative analysis using methods like NMR, GC-MS, or LC-MS. Deuterium substitution can impact the pharmacokinetic and metabolic profiles of drugs. Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, which helps restore Phe508del CFTR protein function and has potential in treating cystic fibrosis. When combined with Tezacaftor and VX-770, it significantly enhances Phe508del CFTR protein processing, trafficking, and chloride transport.
- Tracer and internal standard for quantitative analysis
- Potential to influence pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Potential to treat cystic fibrosis
- Enhances CFTR protein processing, trafficking, and chloride transport
Medchemexpress LLC Cyclin D2/CCND2 Antibody (YA789) | Predicted band size: 33 kDa; Observed band size: 38 kDa | 100 UL
The Cyclin D2/CCND2 Antibody (YA789) is a Mouse-derived, non-conjugated IgG2b monoclonal antibody designed to target Cyclin D2/CCND2. It is suitable for use in Western Blot (WB) applications.
- Mouse-derived
- Monoclonal antibody
- Reacts with human samples
- Supplied in 1x PBS, 50% glycerol, 0.5% BSA, and 0.02% sodium azide
- Recommended storage at -20°C for up to one year
- Affinity purified
- Non-conjugated
- Isotype IgG2b
Medchemexpress LLC Calcipotriol Impurity C | 113082-99-8 | 99.1% | C27H40O3 | 50 MG
Calcipotriol Impurity C is an impurity of Calcipotriol, which is a ligand of VDR-like receptors. It targets the VDR.
- Impurity of calcipotriol
- Ligand of VDR-like receptors
- Targets VDR
- For research use only
Medchemexpress LLC 3-O-Methyldopa-d3 hydrate | 300-48-1 | 232.25 | 1 MG
3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Enzo Life Sciences 25(OH) Vitamin D Controls (1Set)
25(OH) Vitamin D Controls for use with 25(OH) Vitamin D ELISA Kit. Content: 1 high and 1 low control. Long Term Storage: -80°C. Applications: ELISA .
Medchemexpress LLC Cyclin D2/CCND2 antibody (YA789) | Affinity purified | Predicted band size: 33 kDa; Observed band size: 38 kDa | 10 UL
Cyclin D2/CCND2 antibody (YA789) is a mouse-derived, non-conjugated IgG2b monoclonal antibody targeting Cyclin D2/CCND2. It is formulated in 1x PBS (pH 7.3), 50% glycerol, and 0.5% BSA, containing 0.02% sodium azide as a preservative. This antibody is intended for research use only and reacts with human species.
- Host: Mouse
- Clonality: Monoclonal
- Isotype: IgG2b
- Species reactivity: Human
- Purity: Affinity purified
- Applications: Western Blot (WB)
- Immunogen: Synthetic peptide corresponding to human Cyclin D2
- Storage: Store at -20°C for 1 year, avoid repeated freeze/thaw cycles
Medchemexpress LLC Rufinamide-d2 | 1129491-38-8 | C10H6D2F2N4O | 1 MG
Rufinamide-d2 (CGP 33101-d2) is a deuterium-labeled Rufinamide, an orally active antiepileptic compound. It inhibits Na+ current activation and neuronal hyperexcitability, exhibiting anticonvulsant effects. This compound is utilized in the study of Lennox-Gastaut syndrome, with its deuteration influencing pharmacokinetic and metabolic profiles.
- Inhibits Na+ current activation
- Inhibits neuronal hyperexcitability
- Provides anticonvulsant effects
- Used in the study of Lennox-Gastaut syndrome
- Deuterium-labeled for tracer applications
- Influences pharmacokinetic and metabolic profiles
Cayman Chemical -NIcotIn-d3 25mg
An internal standard for the quantification of (±)-nicotine by GC- or LC-MS
Sigma Aldrich Fine Chemicals Biosciences 24R 2425 Dihydroxyvitamin
(24R)-24 25-Dihydroxyvitamin D3 is a metabolite of vitamin D3. It is known to increase bone volume and mechanical strength.
Sigma Aldrich Fine Chemicals Biosciences 2 Keto 3 methyl d3 butyrc500MG
2 Keto 3 methyl d3 butyrc500MG