Steroids and derivatives
Medchemexpress LLC Alpha-Estradiol (Standard) | 57-91-0 | 99.93% | 25 MG
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol, intended for research and analytical applications. It is a weak estrogen and a 5α-reductase inhibitor used as a topical medication in the treatment of androgenic alopecia.
- Reference standard supplied assay
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS
Medchemexpress LLC Estradiol 3-sulfamate | 172377-52-5 | 351.46 | 5 MG
Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor. It inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
- Potent, long-acting, and orally active steroid sulfatase inhibitor.
- Inhibits estrone sulfatase.
- Used for research purposes.
Sigma Aldrich Fine Chemicals Biosciences Ethinyl estradiol Related Compound B United States Pharmacopeia (USP) Reference Standard | 1231-96-5 | 20MG
Ethinyl estradiol Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 294.39 | 1231-96-5 | 20MG
Sigma Aldrich Fine Chemicals Biosciences alpha Estradiol powder 98500MG
alpha Estradiol powder 98500MG
Medchemexpress LLC Estradiol 17-(β-D-Glucuronide) sodium | 15087-02-2 | 98.9% | 50 MG
Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. It functions as a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). This compound regulates and inhibits MRP8-mediated transport processes and can be used in studies related to intrahepatic cholestasis, as it induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats.
- Metabolite of natural estrogen
- Substrate of Oatp and Mrp2
- Regulates and inhibits MRP8-mediated transport processes
- Induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis
- Useful in studies related to intrahepatic cholestasis
- Solid, white to off-white appearance
- Molecular weight of 470.49
- Chemical formula C24H31NaO8
Medchemexpress LLC Estradiol cypionate | 313-06-4 | MFCD00056558 | 99.5% | 1 ML
Estradiol cypionate is the 17β-cypionate ester of Estradiol, inhibiting ET-1 synthesis by acting on estrogen receptors. It is intended for research use only. In vitro, it inhibits proliferation of gastric cancer cells and induces G1/S phase cell cycle arrest and apoptosis by affecting the PI3K/Akt/mTOR pathway. In vivo, it increases cortical bone density in ovariectomized rabbits, increases occurrence of estrus and pregnancy in cows, and inhibits tumor growth in MGC803 nude mice tumor models.
- Inhibits gastric cancer cell proliferation
- Induces G1/S phase cell cycle arrest and apoptosis
- Increases cortical bone density
- Promotes estrus and pregnancy
- Inhibits tumor growth
Apexbio Technology LLC α-Estradiol 57-91-0 10mM (in 1mL Ethanol)
alpha-Estradiol (57-91-0) is a small-molecule inhibitor targeting 5 -reductase the enzyme responsible for converting testosterone to dihydrotestosterone (DHT) It is designed to inhibit 5 -reductase activity thereby modulating androgen metabolism and androgen-related signaling pathways alpha-Estradiol exerts its biological activity primarily through enzyme inhibition In reported experimental studies alpha-Estradiol demonstrates inhibitory activity against 5 -reductase with an IC50 value ranging from approximately 1 to 10 M though the precise value may depend on assay conditions Based on these pharmacological properties alpha-Estradiol holds research potential in the treatment and study of androgenetic alopecia
Medchemexpress LLC β-estradiol-6-CMO-PEG3-biotin | 2938875-38-6 | 97.8% | 759.95 g·mol⁻¹ | C38H57N5O9S | 1 MG
β-Estradiol-6-CMO-PEG3-biotin is a biotinylated estradiol derivative used as a cleavable three-unit polyethylene glycol (PEG3) linker for antibody-drug conjugate (ADC) synthesis. It provides a hydrophilic spacer and a biotin handle to facilitate conjugation, affinity capture, and detection in downstream assays.
- Cleavable three-unit PEG linker providing hydrophilicity and spacing.
- Biotin tag enables affinity capture and detection.
- High purity (97.82%) suitable for research applications.
- Soluble in DMSO at ≥ 50 mg/mL; use freshly opened DMSO.
- Stable as a powder at -20°C for up to 3 years; limited stability in solvent as specified by manufacturer.
Gold Biotechnology Inc Digitonin Special Grade
Digitonin is a nonionic saponin steroid derived from the plant Digitalis purpurea It is useful for creating Digitonin-cholesterol complexes which form when Digitonin disrupts the cell membrane and binds with cholesterol in a nearly 1 1 stoichiometric ratio When precipitated from ethanolic solutions these complexes form flat lamellar sheets Digitonin s cholesterol displacing properties have been used in newer applications to quantify the rate of lysosomal membrane permeabilization (LMP) a new technique developed to bypass traditional cell death pathways Digitonin permeabilizes plasma membranes but leaves lysosomal membranes intact allowing for a quantifiable measurement of lysosomal hydrolases and comparison to normal cellular enzyme activity Digitonin has been shown to induce hemolysis in red blood cells
eMolecules 427-51-0 | Medchem Express | Cyproterone acetate | 250mg | 446263199 | HY-13604 | 402.92 | C23H27ClO4
ChemScene | (R)--Methylbenzenepropanamine | 100mg | 726024285 | CS-0029877 | 937-52-0 | MFCD00145208 | 149.237 | C10H15N
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Medchemexpress LLC Megestrol | 3562-63-8 | 99.4% | 50 MG
Megestrol is a synthetic progestin used for treating anorexia, cachexia, or unexplained significant weight loss in patients diagnosed with acquired immunodeficiency syndrome.
Features:
- Purity of 99.44%
- Molecular weight of 342.47
- Chemical formula is C22H30O3
- Appears as a solid
- Color is white to off-white
- Soluble in DMSO up to 70 mg/mL
- Stock solutions can be stored at -80°C for 2 years or -20°C for 1 year
- Storage condition is refrigerator
- Investigated in clinical trials for various conditions, including endometrial carcinoma, anorexia, cachexia, and cancer
Apexbio Technology LLC Mifepristone, 1g. Cas: 84371-65-3 MFCD: MFCD00867226. Progesterone receptor antagonist
Mifepristone (RU486) is a potent antagonist of progesterone receptor, used as a contraceptive agent. 84371-65-3. MFCD00867226