Purine nucleosides
Medchemexpress LLC Deoxyguanosine triphosphate trisodium solution | 93919-41-6 | 99.95% | 573.13 | 28.66 MG
Deoxyguanosine triphosphate (dGTP) trisodium solution (100mM) is a nucleotide precursor in cells for DNA synthesis. It is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification. Deoxyguanosine triphosphate is abnormally elevated in the red blood cells of individuals with immunodeficiency related to purine nucleoside phosphorylase deficiency, and it can be regarded as a potential toxic metabolite.
- Nucleotide precursor for DNA synthesis.
- Used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification.
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.9% | 269.26 | 50 G
2'-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. It also inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation, activates caspase-3, promotes apoptosis, and inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). Additionally, it inhibits the growth of various cells and exhibits an anticancer effect on colon cancer.
- Inhibits glucose-stimulated insulin release.
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation.
- Activates caspase-3 and promotes apoptosis.
- Inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH).
- Inhibits the growth of various cells.
- Has an anticancer effect on colon cancer.
Medchemexpress LLC 3′-Deoxyguanosine | 3608-58-0 | 97.0% | 267.25 | 25 MG
3′-Deoxyguanosine is a derivative of Guanosine. It interacts with human purine nucleoside phosphorylase through hydrogen bonding with residues like Glu201 and Asn243. This compound demonstrates moderate displacement activity for [3H]-guanosine in rat meninges and is useful for studying the mechanism of guanosine receptors and purine metabolism.
- Derivative of guanosine.
- Interacts with human purine nucleoside phosphorylase via hydrogen bonding.
- Exhibits moderate displacement activity for [3H]-guanosine in rat meninges.
- Useful for studying guanosine receptor mechanisms.
- Useful for studying purine metabolism.
- Displaces 50 nM [3H]-guanosine binding to rat brain membranes.
Apexbio Technology LLC 6-O-Propynyl-2-deoxyguanosine 1mg
6-O-Propynyl-2-deoxyguanosine (CAS 1640051-47-3) is a modified nucleoside featuring an alkyne functional group at the 6-position of deoxyguanosine This structural modification enables its use in bioorthogonal click chemistry reactions facilitating site-specific labeling and conjugation in nucleic acid research The alkynyl group serves as a chemical handle for copper-catalyzed azide-alkyne cycloaddition allowing researchers to attach probes or other functional molecules 6-O-Propynyl-2-deoxyguanosine is utilized for studying DNA structure dynamics and for the development of modified oligonucleotides in biochemical and molecular biology assays
Medchemexpress LLC 2'-Deoxyguanosine 5'-monophosphate disodium hydrate | 146877-98-7 | 99.0% | C10H14N5O7.H2O.2Na | 100 MG
2'-Deoxyguanosine 5'-monophosphate disodium hydrate (dGMP) is an oxidizable target of the photosensitizer pterin. It can be used to evaluate the photosensitizing properties of biopterins. Pterin causes a photosensitive reaction of dGMP under UV-A radiation, leading to DNA damage. This process involves two main mechanisms in vitro for the photosensitive oxidation of purine nucleotides by pterin.
- A hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism).
- Interaction between dGMP and pterin produces singlet molecular oxygen (1O2) (type II mechanism).
Medchemexpress LLC 2'-deoxyadenosine-13C10 | ≥99.0% | 261.17 | 13C10H13N5O3 | 1 MG
2'-deoxyadenosine-13C10 is a 13C-labeled isotope standard of 2'-deoxyadenosine intended for use as an analytical reference and tracer in biochemical and mass spectrometry assays.
- Isotope-labeled standard for analytical and tracer studies.
- Molecular formula: 13C10H13N5O3.
- Molecular weight: 261.17 g/mol.
- Purity: ≥99.0%.
- Supplied as a 1 mg vial.
- Suitable for use in mass spectrometry and quantitative assays.
Medchemexpress LLC 2′-deoxyguanosine 5′-monophosphate-13C10,15N5 dilithium | MFCD00080331 | 99.8% | 373.98 g/mol | 13C10H12Li215N5O7P | 5 MG
2′-Deoxyguanosine 5′-monophosphate-13C10,15N5 dilithium is a stable isotope-labeled nucleotide supplied as the dilithium salt for quantitative analytical applications. The 13C and 15N labelling enables accurate tracing and quantitation in mass spectrometry and NMR workflows.
Cayman Chemical N6-Methyl-2-deoxyadenosIn 25mg
A nucleoside and inducer of EPC proliferation; stimulates the proliferation of EPCs isolated from mouse fetal livers and colony formation of isolated mouse bone marrow cell-derived progenitor cells at 10 and 100 µM; accumulates along promoters and gene coding sequences in activated mouse prefrontal cortical neurons; is associated with activation at the Bdnf promoter
Medchemexpress LLC 2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium | 1927-31-7 | 95.0% | 512.97 | 1 MG
2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium (dATP-13C10 dilithium) is a 13C-labeled version of 2'-Deoxyadenosine-5'-triphosphate (dATP). dATP is a nucleotide crucial for DNA synthesis or replication in cells, serving as a substrate for DNA polymerase.
- Used as a tracer
- Used as an internal standard for quantitative analysis
- Suitable for analysis by NMR
- Suitable for analysis by GC-MS
- Suitable for analysis by LC-MS
Medchemexpress LLC Malvidin-3-O-arabinoside chloride | 28500-04-1 | 97.1% | 498.86 | 5 MG
Malvidin-3-O-arabinoside chloride (M3A chloride) is a research chemical that ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. It is used in studies to understand cellular processes related to oxidative stress and autophagy.
- Stimulates phosphorylation of AMP-activated protein kinase (AMPK)
- Upregulates LAMP-1 expression
- Restores lysosomal acidity and strengthens lysosomal functions
- Inhibits excess reactive oxygen species (ROS) generation
- Enhances glutathione (GSH) levels and autophagy flux
- Upregulates LC3-II/LC3-I ratio
Cayman Chemical N6-benzoyl-2-DeoxyadenosIn 1g
A nucleoside building block; has been used in the synthesis of various oligonucleotides
Cayman Chemical 5-chloro-5-DeoxyadenosIn 10g
A nucleoside analog used as a substrate in the biosynthesis of the anticancer agent salinosporamide A
Cayman Chemical N6-benzoyl-2-DeoxyadenosIn 5g
A nucleoside building block; has been used in the synthesis of various oligonucleotides
Medchemexpress LLC 2'-deoxyguanosine-13C monohydrate | 478511-26-1 | MFCD00080300 | 99.9% | 286.25 g/mol | C9(13)CH15N5O5 | 10 MG
2'-Deoxyguanosine-13C monohydrate is the carbon-13 isotopically labeled form of 2'-deoxyguanosine provided as the monohydrate solid for analytical and research applications, including metabolic flux analysis and isotope-tracing studies. The material is supplied with documentation (COA, SDS) and is intended for research use only.
- 13C labeled 2'-deoxyguanosine.
- Monohydrate solid form.
- Purity: 99.9% (HPLC).
- Molecular weight: 286.25 g/mol.
- Chemical formula: C9(13)CH15N5O5.
- CAS number: 478511-26-1.
- Typical pack size: 10 mg.
- Documentation available: COA and SDS for handling and storage.
- For research use only; not for human use.