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Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis rheumatoid arthritis discoid and systemic lupus erythematosus.
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Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid intestinal cells blood-brain barrier and in brain microvessels.
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In the extracellular space ecto-5AE-nucleotidase (CD73) dephosphorylates adenosine triphosphate (ATP) to produce adenosine. Adenosine has four receptors namely A1R A2AR A2BR and A3R. Adenosine plays a key role in the osteogenic differentiation. A1R induces osteoclast differentiation and A2AR induces osteoblast differentiation.
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