Purine nucleotides
Medchemexpress LLC Adenosine 5'-triphosphate dimagnesium | 74804-12-9 | 98.0% | 500 MG
ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo, providing metabolic energy to drive metabolic pumps and serving as a coenzyme in cells. It is also an important endogenous signaling molecule in immunity and inflammation.
- Synergistically activates the NLRP3 inflammasome in HGFs when co-treated with LPS.
- Induces secretion of IL-1β, KC, and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.
- Promotes neutrophil chemotaxis in vitro.
- Protects mice against bacterial infection in vivo.
- Induces the secretion of IL-1β, KC, and MIP-2 and neutrophils recruitment in vivo.
Medchemexpress LLC Guanosine 5'-diphosphate sodium | 43139-22-6 | 99.9% | 465.18 | 10 MG
Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channels. It functions as an iron mobilizer by forming a complex with hepcidin, inhibiting the hepcidin-ferroportin (FPN) interaction and modulating the IL-6/Stat-3 pathway. This compound can ameliorate Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4, making it suitable for research on AI.
- Activates adenosine 5'-triphosphate-sensitive K+ channels.
- Functions as an iron mobilizer.
- Inhibits hepcidin-ferroportin (FPN) interaction.
- Modulates the IL-6/Stat-3 pathway.
- Ameliorates Turpentine-induced anemia of inflammation (AI) in mice.
- Suitable for research on anemia of inflammation.
Apexbio Technology LLC 2-Amino-ATP(Synonyms: 2-NH2-ATP, 2-Aminoadenosine triphosphate, 2-Amino-adenosine-5'-triphosphate, 2-Amino-ATP (free acid)), 100ul (100 mM).
2-Amino-ATP is a modified nucleotide structurally related to ATP (adenosine triphosphate) featuring an amino substitution at the adenine ring s 2-position It acts as an ATP analog capable of competitively binding at the active sites of ATP-dependent enzymes potentially modulating their enzymatic activity and influencing downstream signaling pathways In research settings 2-Amino-ATP serves as a molecular tool to examine substrate specificity mechanistic aspects of ATP-binding enzymes (e g kinases and ATPases) and nucleotide-dependent receptor interactions facilitating studies of nucleotide signaling and cellular metabolism
Medchemexpress LLC Guanosine (Standard) | 118-00-3 | 99.5% | 283.24 | 250 MG
Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. It exhibits anti-HSV activity. As an analytical standard, it is intended for research and analytical applications. In vitro, Guanosine can be phosphorylated into guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP), which are crucial for various biochemical processes including nucleic acid and protein synthesis, photosynthesis, muscle contraction, and intracellular signal transduction.
- Used as a reference standard for assays.
- Commonly utilized in qualitative, quantitative, and methodological research experiments.
- Supports applications such as HPLC, GC, and MS.
Medchemexpress LLC Kinetin triphosphate tetrasodium | 00-00-0 | 99.9% | C15H16N5Na4O14P3 | 10MG
Kinetin triphosphate tetrasodium is an ATP analogue used in biochemical and kinase research, including investigations of mitochondrial quality control pathways. It is supplied as a tetrasodium salt in small milligram quantities and includes documentation for experimental use and handling.
- ATP analogue for kinase and enzymology assays.
- High purity (99.92%) suitable for sensitive biochemical studies.
- Soluble in water with recommended reconstitution guidance (100 mM preparations).
- Provided in small research quantities for experimental flexibility.
- Documentation includes datasheet, certificate of analysis, and safety data sheet.
Apexbio Technology LLC Adenosine 5-triphosphate 34369-07-8 500mg
Adenosine 5-triphosphate (ATP CAS 34369-07-8) also known as ATP disodium salt hydrate is a nucleotide central to cellular energy transfer It functions as the primary intracellular energy carrier undergoing hydrolysis to release energy required for numerous biochemical processes including muscle contraction signal transduction and biosynthetic reactions ATP also serves as a substrate for kinases in phosphorylation events and plays a regulatory role in purinergic signaling pathways In biomedical research ATP is widely used to study cellular metabolism enzyme activities and receptor-mediated responses
Medchemexpress LLC Guanosine 5'-triphosphate trisodium salt hydrate | 207300-85-4 | 95.0% | 100 MG
Guanosine 5'-triphosphate trisodium salt hydrate is an activator of the signal transducing G proteins and serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
- Activator of signal transducing G proteins
- Energy-rich precursor in DNA and RNA biosynthesis
- For research use only
Medchemexpress LLC Guanosine 5'-triphosphate trisodium salt hydrate | 207300-85-4 | 95.0% | 50 MG
Guanosine 5'-triphosphate trisodium salt hydrate (5'-GTP trisodium salt hydrate) is a chemical reagent that functions as an activator for signal transducing G proteins. It also serves as an energy-rich precursor of mononucleotide units, which are essential for the enzymatic biosynthesis of DNA and RNA. This product is intended for research use only.
- Functions as an activator for signal transducing G proteins.
- Serves as an energy-rich precursor of mononucleotide units.
- Essential for the enzymatic biosynthesis of DNA and RNA.
- Intended for research use only.
Medchemexpress LLC Tyrosine kinase inhibitor | 34823-86-4 | 99.9% | 234.25 | 1 ML
GTP-14564 is a tyrosine kinase inhibitor targeting internal tandem duplication (ITD) and FLT3, which inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells.
- Targets internal tandem duplication (ITD) and FLT3.
- Inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells.
- Used in cancer targeted therapy.
- Functions as an inhibitor of Fms-like tyrosine kinase 3 (FLT3).
Medchemexpress LLC GTP-14564 | 34823-86-4 | 99.9% | 234.25 | 50 MG
GTP-14564 is a tyrosine kinase inhibitor that targets internal tandem duplication (ITD) and FLT3. It inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells.
- Tyrosine kinase inhibitor targeting ITD and FLT3
- Inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells
- Solid, off-white to yellow color
Medchemexpress LLC GTP-14564 | 34823-86-4 | 99.9% | 234.25 | 10 MG
GTP-14564 is a tyrosine kinase inhibitor that targets internal tandem duplication (ITD) and FLT3. It inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells.
- Tyrosine kinase inhibitor
- Targets ITD and FLT3
- Inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells
- Available in various quantities
- Available as solid or in solution (10 mM in DMSO)
- Off-white to yellow solid appearance
- For research use only
- Has a data sheet, COA, SDS, and handling instructions available
Medchemexpress LLC GTP-14564 | 34823-86-4 | 99.9% | 234.25 | 25 MG
GTP-14564 is a tyrosine kinase inhibitor that targets internal tandem duplication (ITD) and FLT3. It inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells.
- Tyrosine kinase inhibitor
- Targets ITD and FLT3
- Inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells
Medchemexpress LLC Adenosine | 58-61-7 | 100.0% | 50 G
Adenosine is a ubiquitous and BBB-permeable endogenous autacoid, acting through four G protein-coupled receptors (A1, A2A, A2B, and A3). It influences nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation. As an extracellular signaling molecule derived from 5'-adenosine triphosphate (ATP) and 5'-adenosine monophosphate (AMP), it plays a critical role in cellular processes.
- Influences neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
- Acts via G protein-coupled receptors: A1, A2A, A2B, and A3.
- Inhibits cell viability and triggers ER stress in HepG2 cells at high concentrations.
- Induces apoptosis and autophagy in HepG2 cells via the AMPK/mTOR pathway.
Medchemexpress LLC Adenosine-13C5 | 159496-13-6 | 99.9% | 1 MG
Adenosine-13C5 is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
- Isotope-labeled compound, incorporating a stable heavy isotope of carbon (13C).
- Used as a tracer and internal standard for quantitative analysis by techniques like NMR, GC-MS, or LC-MS.
- Plays a crucial role in various cellular physiological processes.
- Purity of 99.9%.
- Appears as a white to off-white solid.
- Soluble in DMSO (33.33 mg/mL) and H2O (≥ 6.67 mg/mL).
- Recommended storage as a powder at -20°C for 3 years or 4°C for 2 years.
- In solvent, recommended storage at -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Adenosine (Standard) | 58-61-7 | 99.39% | 50 MG
Adenosine (Standard) is the analytical standard of Adenosine, intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. It affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
- Analytical standard for research and analytical applications
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS