Drug Standards
![AdipoGen MLN4924 [NAE Inhibitor] Solution,Chemical. CAS: 905579-51-3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501146629.PNG-250.jpg)
AdipoGen MLN4924 [NAE Inhibitor] Solution,Chemical. CAS: 905579-51-3
MLN4924 [NAE Inhibitor] Solution, AdipoGen Life Sciences. Chemical. CAS: 905579-51-3. Formula: C21H25N5O4S. MW: 443.5. Potent, selective and cell-permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE). By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis.
AdipoGen Rosiglitazone, 122320-73-4, MFCD00871760, 10 mg
MF: C18H19N3O3S, MW: 357.4, ≥98%, Appearance: White to off-white powder. Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells (NPCs). Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs).
AdipoGen Colchicine,Chemical. CAS: 64-86-8
Colchicine, AdipoGen Life Sciences. Chemical. CAS: 64-86-8. Formula: C22H25NO6. MW: 399.4. Isolated from Colchicum autumnale. Anti-cancer compound. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Anti-inflammatory compound. Suppresses monosodium urate crystal-induced NLRP3/NALP3 inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils at micromolar concentrations. Blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils at nanomolar concentrations. Drug used in treatment of gout, familial Mediterranean fever, pericarditis and Behect's disease. Investigated for its anti-cancer activity.
AdipoGen Cisplatin, 15663-27-1, MFCD00011623, 250 mg
MF: Cl2H6N2Pt, MW: 300.0, ≥98%, Appearance: Yellow solid. Potent platinum-based antineoplastic agent, Anticancer compound, Forms inter- and intrastrand DNA adducts/crosslinks, consequently blocking DNA replication and transcription and inducing cell death, Nephrotoxic when used in vivo, and potent chemoimmunotherapeutic. Stimulates the immune responses by activating macrophages and other cells of the immune system.
AdipoGen Vincristine Sulfate, 2068-78-2, MFCD08706469, 5 mg
MF: C46H56N4O10 . H2SO4, MW: 923.044, ≥98%, Appearance: White to light-yellow powder. Immunosuppressant. Anticancer compound. Chemotherapeutic agent. Depolymerizes microtubules and irreversibly blocks binding of tubulin to microtubule proteins. Apoptosis inducer and cell cycle inhibitor in G2/M phase. Autophagy inhibitor. Inhibits microtubule-mediated fusion of autophagosome with lysosme. Inducer of IL-1beta production. Activates alone and synergistically together with doxorubicin the NLRP3-inflammasome mediated processing of IL-1beta. Monoamine oxidase (MAO) inhibitor.
AdipoGen Tofacitinib, 477600-75-2, MFCD11035919, 5 mg
MF: C16H20N6O, MW: 312.4, ≥98%, Appearance: Off-white to pale yellow solid. Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity. Immunosuppressive and anti-inflammatory agent. Inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional selectivity over JAK2-paired receptors. Blocks downstream STAT signaling, resulting in potent inhibition of several cytokines, including interleukins 2, 4, 7, 9, 15 and 21, which are integral to lymphocyte activation, function and proliferation. Investigated for several autoimmune disorders including, rheumatoid arthritis and psoriasis. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.
Sigma Aldrich Fine Chemicals Biosciences Irinotecan hydrochloride | 100286-90-6 | MFCD01862255 | 50mg
Irinotecan hydrochloride | Purity: 97% | MW: 623.14 | 100286-90-6 | MFCD01862255 | 50mg
Selleck Chemical LLC Liraglutide 1mg 204656-20-2 Victoza, Liraglutida, Liraglutidum, NN2211, NN-2211
Liraglutide (Victoza, Liraglutida, Liraglutidum, NN2211) is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Cell-permeable proteasome inhibitor 179324-69-7. MFCD09056737
Cell-permeable proteasome inhibitor 179324-69-7. MFCD09056737
Apexbio Technology LLC Alverine Citrate 5560-59-8 10mM (in 1mL DMSO)
Alverine citrate (CAS 5560-59-8) is a synthetic small-molecule compound employed primarily in studies of functional gastrointestinal disorders It exerts antispasmodic effects predominantly via calcium channel blockade reducing smooth muscle contraction and alleviating gastrointestinal symptoms Biomedical researchers utilize alverine citrate to examine gut motility mechanisms visceral hypersensitivity pathways and potential therapeutic approaches for gastrointestinal dysfunction
Medchemexpress LLC Ruxolitinib (Standard) | 941678-49-5 | MFCD12031592 | 99.74% | C17H18N6 | 25 MG
Ruxolitinib (Standard) is the analytical standard of Ruxolitinib, intended for research and analytical applications. It functions as a potent and selective JAK1/2 inhibitor, inducing autophagy and leading to the elimination of tumor cells through toxic mitophagy.
- Potent and selective JAK1/2 inhibitor
- Induces autophagy and kills tumor cells
- Suitable for qualitative, quantitative, and methodological research experiments
- Commonly used in HPLC, GC, and MS