Drug Standards
Advanced Chemblocks Inc Ramatroban; 100MG; 98%
Chemical Name: Ramatroban CAS: 116649-85-5 #N/A MDL Number: MFCD00887606 Category: Reference Compound Synonym: Ramatroban
Selleck Chemical LLC Minocycline HCl S4226-200mg
Minocycline HCl is the most lipid soluble and most active tetracycline antibiotic binds to the 30S ribosomal subunit preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis
Medkoo Biosciences Inc Nicotinamide Riboside Chloride | 23111-00-4 | MFCD27952781 | 100g
Nicotinamide Riboside Chloride | Putity: > 98% | MW: 290.7 | 23111-00-4 | MFCD27952781 | 100g
Apexbio Technology LLC Diltiazem HCl 33286-22-5 10mM (in 1mL DMSO)
Diltiazem HCl is a small-molecule inhibitor targeting L-type calcium channels predominantly located on cardiac and vascular smooth muscle cells It is designed to inhibit calcium influx thereby reducing intracellular calcium concentrations and regulating muscle contraction and cardiac conduction Diltiazem HCl exerts its biological activity primarily through blockade of L-type calcium channels resulting in vascular smooth muscle relaxation decreased myocardial contractility slowed cardiac conduction reduced heart rate and coronary artery dilation Based on these pharmacological properties Diltiazem HCl holds research potential in cardiovascular pharmacology specifically for studies investigating mechanisms underlying cardiac arrhythmias ischemic heart conditions hypertension and related therapeutic interventions
Apexbio Technology LLC Triamcinolone 124-94-7 10mM (in 1mL DMSO)
Triamcinolone (124-94-7) is a small-molecule agonist targeting intracellular glucocorticoid receptors (GR) It is designed to modulate the transcriptional regulation of genes involved in inflammation immune responses cellular proliferation vascular permeability and angiogenesis thereby regulating multiple cellular and immunological pathways Triamcinolone exerts its biological activity primarily through binding to GR and modulating downstream gene expression In cell-based GR assays Triamcinolone demonstrates potent receptor binding with reported IC50 values typically ranging from 0 5 to 5 nM Based on these pharmacological properties Triamcinolone holds research potential in experimental models of dermatological inflammation ophthalmic inflammation autoimmune conditions and investigations of GR-mediated signal transduction and immunoregulatory pathways
Apexbio Technology LLC Norfloxacin hydrochloride 104142-93-0 10mM (in 1mL DMSO)
Norfloxacin hydrochloride is a small-molecule inhibitor targeting bacterial DNA gyrase It is designed to inhibit DNA gyrase an enzyme essential for the supercoiling and replication of bacterial DNA thereby disrupting bacterial DNA synthesis and interfering with bacterial replication and growth Norfloxacin hydrochloride exerts its biological activity primarily through the inhibition of DNA gyrase by binding within the enzyme s active site impeding its catalytic activity Based on these pharmacological properties Norfloxacin hydrochloride holds research potential in the study of bacterial resistance mechanisms bacterial enzyme inhibition assays antimicrobial susceptibility testing and therapeutic research on antibacterial treatment strategies against Gram-positive and Gram-negative bacteria
Apexbio Technology LLC Sorafenib Tosylate 475207-59-1 200mg
Sorafenib tosylate (CAS 475207-59-1) is an orally bioavailable multi-kinase inhibitor that targets Raf serine/threonine kinases and vascular endothelial growth factor receptors (VEGFR) thereby impeding tumor cell proliferation and angiogenesis In vitro it demonstrates an IC50 of 2 09 g/ml in HepG2 hepatocellular carcinoma cells and 0 88 nM in MV4-11 (FLT3-ITD) leukemia cells with dose-dependent antiproliferative and pro-apoptotic effects observed in leukemia cell lines at nanomolar concentrations In vivo administration in a breast cancer bone metastasis model significantly reduces osteolytic lesion volume and soft tissue components compared to controls Sorafenib tosylate is widely employed in oncology research to investigate signal transduction tumor growth and angiogenic pathways
Apexbio Technology LLC (+)-Ketoconazole 142128-59-4 10mg
( )-Ketoconazole (CAS 142128-59-4) is a small-molecule inhibitor targeting cytochrome P450 enzymes primarily CYP3A4 and P450c17 (CYP17A1) It is designed to inhibit these enzymes thereby blocking steroidogenesis pathways and reducing androgen biosynthesis ( )-Ketoconazole exerts its biological activity primarily through inhibition of CYP3A4 and CYP17A1 In in vitro studies ( )-Ketoconazole demonstrates inhibitory activity with reported IC50 values in the low nanomolar to submicromolar range Based on these pharmacological properties ( )-Ketoconazole holds research potential in studying steroid hormone biosynthesis pathways and the biological functions regulated by cytochrome P450 enzyme activity particularly in investigations involving androgen-dependent cell models and related endocrine mechanisms
Cayman Chemical R-CrIzotInIb 50mg
A dual inhibitor of c-Met and ALK (IC50s = 8 and 20 nM, respectively, in a cell-based assay); selective for c-Met and ALK over several other receptor and non-receptor tyrosine kinases, including Ron, Tie2, Abl, LCK, and VEGFR2 (IC50s = 0.08, 0.448, 1.159, 2.741, and >10 µM, respectively); selectively inhibits the proliferation of cancer cell lines with MET amplifications over cancer cell lines with MET or EGFR mutations (IC50s = 5-10, 472-1,284, and 767-787 nM, respectively); induces apoptosis in MET-amplified EBC-1 and NCI H1993 cells at 100 nM; reduces tumor volume in an EBC-1 mouse xenograft model at 25 mg/kg