Drug Standards
Medchemexpress LLC 5H-1-Benzazepin-5-one, 1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro- | 137977-97-0 | 99.9% | 328.80 | 500 MG
Tolvaptan Impurity from MedChemExpress is a chemical compound with the molecular formula C18H17ClN2O2 and a molecular weight of 328.80. It is provided as a white to off-white solid with a purity of 99.92%. This product is intended for research use only and has not been fully validated for medical applications.
- Provided as a white to off-white solid
- Purity of 99.92%
- Suitable for research applications
- Store as powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Cayman Chemical MogrosIde IIIE 25mg
A cucurbitane glycoside with anti-inflammatory activity; inhibits LPS-induced secretion of IL-1β, IL-6, and TNF-α from, as well as LPS-induced increases in TLR4 levels in, RAW 264.7 macrophages at 50 µM; reduces increases in BALF levels of IL-1β, IL-6, and TNF-α, and increases in lung tissue Mpo activity in a mouse model of LPS-induced acute lung injury at 20 mg/kg; decreases lung fibrosis and inflammation, as well as increases animal survival and reduced lung levels of MMP-9, in a mouse model of bleomycin-induced pulmonary fibrosis at 20 mg/kg per day
AdipoGen Tamoxifen 10540-29-1, 1 g
Tamoxifen (1 g), AdipoGen Life Sciences. Chemical. CAS: 10540-29-1. Formula: C26H29NO. MW: 371.51. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature system. This prodrug is metabolized by cytochrome P450 (CYP450) enzymes to the active metabolites N-desmethyl-TMX, 4-hydroxy-N-desmethyl-TMX (endoxifen) and 4-hydroxy-TMX (afimoxifene). N,N-Didesmethyl-4-hydroxytamoxifen (norendoxifen), another active metabolite has been found to act as a potent competitive aromatase inhibitor and may also be involved in its antiestrogenic activity. Binds microsomal antiestrogen binding sites, altering cholesterol esterification at therapeutic doses and impacting breast cancer cell differentiation, apoptosis, and autophagy. Protein kinase C (PKC) inhibitor and anti-angiogenetic factor.
Cayman Chemical FamcIclovIr 25mg
An orally bioavailable prodrug form of penciclovir; oxidized in vitro by human, guinea pig, and rat liver aldehyde oxidase; in rats the peak concentrations of penciclovir in plasma (mean 3.5 μg/ml) occur in 0.5 hours (40 mg/kg); in dogs the peak concentrations of penciclovir in plasma (mean 4.4 μg/ml) occur in 3 hours (25 mg/kg)
Cayman Chemical Itraconazole 25mg
An antifungal agent and hedgehog pathway inhibitor; inhibits hedgehog signaling (IC50 = 0.8 μM); binds to 14-α sterol demethylase/CYP51 isoform B (Kd = 31 nM for A. fumigatus enzyme expressed in E. coli); inhibits ergosterol biosynthesis in C. neoformans (IC50 = 6 nM after 16 hours); inhibits C. neoformans growth by 50% at 3.2 nM; suppresses growth of medulloblastomas in a Ptch+/-p53-/- mouse allograft model at 100 mg/kg twice daily; reduces viral titers of several enteroviruses in infected cells from 1.25-100 µM
Apexbio Technology LLC Flavopiridol hydrochloride 131740-09-5 10mM (in 1mL DMSO)
Flavopiridol hydrochloride is a selective inhibitor of cyclin-dependent kinases (CDKs) specifically targeting CDK1 CDK2 CDK4 and CDK6 with reported IC50 values approximately 41 nM and CDK7 with an IC50 of about 300 nM Additionally it has been observed to inhibit EGFR and protein kinase A at micromolar concentrations By inhibiting CDK activity flavopiridol hydrochloride disrupts cell cycle progression inducing G1 phase arrest as demonstrated in breast cancer cell lines Furthermore its capacity to inhibit phosphorylation of Rb protein and suppress anti-apoptotic proteins such as Mcl-1 and XIAP facilitates apoptosis in lymphoma cell models Flavopiridol hydrochloride is utilized in preclinical studies of cell cycle regulation apoptosis signaling and cancer research including experiments using xenograft tumor models in mice
Medchemexpress LLC (±)11(12)-EET-d11 | 2699607-19-5 | 98.0% | 10 UG
(±)11(12)-EET-d11 is a deuterium labeled form of (±)11(12)-EET, functioning as an NLRP3 inflammasome inhibitor. It is used in research for anti-inflammatory, angiogenic, and cardioprotective effects. This compound can serve as a tracer and an internal standard for quantitative analysis by techniques like NMR, GC-MS, or LC-MS.
- Deuterium labeled compound
- Inhibits NLRP3 inflammasome
- Used in anti-inflammatory, angiogenic, and cardioprotective research
- Functions as a tracer
- Serves as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
Apexbio Technology LLC Bumetanide 10mM (in 1mL DMSO)
A1855 is a small molecule compound developed for biomedical research applications As a research reagent it is primarily utilized to investigate biological pathways at the molecular level and elucidate potential therapeutic mechanisms Its precise molecular target and mechanism of action have not yet been publicly characterized Researchers employ A1855 as a chemical probe in various experimental systems to explore cellular signaling pathways and identify modulators of biological processes aiding in drug discovery and basic biomedical research
Apexbio Technology LLC Losartan Potassium (DuP 753) 124750-99-8 10mM (in 1mL DMSO)
Losartan Potassium (DuP 753 CAS 124750-99-8) is a small molecule antagonist selective toward angiotensin AT receptors By competitively blocking AT receptors it inhibits angiotensin II-mediated vasoconstriction demonstrated by antagonism of contractile responses in isolated rabbit aortic and jugular vein tissues (pA 8 27) As an orally bioavailable agent losartan potassium is frequently utilized in cardiovascular research notably in studies investigating hypertension and associated mechanisms of angiotensin II signaling
Medchemexpress LLC Isosorbide mononitrate | 16051-77-7 | 100.0% | 1 ML
Isosorbide mononitrate is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. It increases the viability and proliferation of HUVECs by decreasing apoptosis and elevating the expressions of vegf, kdrl, pdgfr in zebrafish embryos. It is promising for research of heart failure and coronary heart disease.
- Dilates blood vessels and lowers blood pressure
- Increases HUVECs viability and proliferation
- Decreases HUVECs apoptosis
- Elevates expressions of vegf, kdrl, and pdgfr in zebrafish embryos
- Inhibits angiogenesis, tumor growth, and metastasis
- Suitable for research of heart failure and coronary heart disease
Medchemexpress LLC Ramipril (HOE-498) | 87333-19-5 | 99.4% | 1 ML
Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5 nM. It enhances the activity of ACE-associated CK2 and the phosphorylation of ACE Ser1270 in cultured endothelial cells. Chronic in vivo administration to rats significantly reduces LPS-induced apoptosis. It inhibits systolic blood pressure (SBP) with an IC50 of 1.97 mg/kg in spontaneously hypertensive rats (SHR).
- Potent angiotensin-converting enzyme (ACE) inhibitor
- Enhances ACE-associated CK2 activity
- Reduces LPS-induced apoptosis in rats
- Inhibits systolic blood pressure (SBP)
- For research use only
Medchemexpress LLC Insulin lispro | 133107-64-9 | 5807.63 | 100 MG
Insulin lispro is a recombinant human insulin analogue and is one of three rapid-acting insulin analogues available. It can be used for the research of hyperglycaemia in diabetes mellitus.
- For research use only.
- Available in multiple sizes.
- Estimated time of arrival for select sizes.
- Controlled substance, not for sale in all territories.