Drug Standards
Medchemexpress LLC Aminopterin (4-aminofolic acid) | 54-62-6 | 98.7% | C19H20N8O5 | 100 MG
Aminopterin (4-Aminofolic acid) is a 4-amino derivative of folic acid and acts as a folic acid antagonist. It catalyzes the reduction of folic acid to tetrahydrofolic acid and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. This compound exhibits anticancer and immunosuppressive activities and is utilized in the treatment of pediatric leukemia.
- Folic acid antagonist
- Catalyzes reduction of folic acid to tetrahydrofolic acid
- Competitively inhibits dihydrofolate reductase (DHFR)
- Anticancer activity
- Immunosuppressive activity
- Used in the treatment of pediatric leukemia
Medchemexpress LLC Octyl gallate | 1034-01-1 | 282.33 | 100 MG
Octyl gallate (Progallin O) is widely used as a food additive with antimicrobial and antioxidant activity. It also shows selective and sensitive fluorescent properties and has a marked antiviral effect against HSV-1, vesicular stomatitis virus (VSV), and poliovirus. It also exhibits antimicrobial activity over H. pylori, with a minimum inhibitory concentration (MIC) value of 125 μg/mL.
- Widely used as a food additive.
- Exhibits antimicrobial and antioxidant activity.
- Shows selective and sensitive fluorescent properties.
- Possesses marked antiviral effect against HSV-1, vesicular stomatitis virus (VSV), and poliovirus.
- Demonstrates antimicrobial activity over H. pylori, with a minimum inhibitory concentration (MIC) value of 125 μg/mL.
Cayman Chemical 1R-Camphor 500mg
A terpene with diverse biological activities; it inhibits DMPP-induced norepinephrine secretion and cytosolic calcium and sodium increases in chromaffin cells (IC50s = 70, 88, and 19 μM, respectively); induces proliferation of and increases expression of collagen IA, collagen IIIA, collagen IVA, and elastin in human primary dermal fibroblasts from 65-260 μM; increases expression of collagen IA, collagen IIIA, collagen IVA, and elastin in skin in UV-exposed mice at 26 and 55 mM in drinking water post UV-exposure; reduces cough frequency in citric acid-challenged guinea pigs; reduces digging activity and induces mortality in fire ant workers; has been used as a building block in the synthesis of cannabinergic ligands
Sigma Aldrich Fine Chemicals Biosciences Carbimazole European Pharmacopoeia (EP) Reference Standard | 22232-54-8 |
Carbimazole European Pharmacopoeia (EP) Reference Standard | Mol Wt: 186.23 | 22232-54-8 |
Medchemexpress LLC Elacridar (GF120918) | 143664-11-3 | MFCD00912604 | 99.7% | C34H33N3O5 | 100 MG
Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. It can be utilized to investigate the influence of efflux transporters on agent distribution to the brain and in cancer research. This product is for research use only.
- Inhibits P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP)
- Utilized to examine efflux transporters on agent distribution to the brain
- Used in cancer research
- Affects P-glycoprotein and ABCG2 protein expression levels
- Impacts 99mTc-MIBI intracellular accumulation
- Shows differential distribution in brain and plasma
Medchemexpress LLC Tenofovir Disoproxil (fumarate) | 202138-50-9 | 99.7% | 635.51 | 100 MG
Tenofovir Disoproxil fumarate is a nucleotide reverse transcriptase inhibitor employed in the treatment of HIV and chronic Hepatitis B. This compound demonstrates significant antiretroviral and anti-HBV activity, making it a crucial agent in managing these viral infections.
- Potent nucleotide reverse transcriptase inhibitor
- Effective against HIV and chronic Hepatitis B
- High purity of 99.7%
- Targets HIV and HBV through anti-infection pathways
- Demonstrates cytotoxic and anti-viral effects in cellular models
- Proven to reduce HIV transmission in in vivo studies
- Induces dose-dependent decline in viremia in chronic HBV models
eMolecules 98-92-0 | Niacinamide | Chem-Impex | MFCD00006395 | 122.127 | C6H6N2O | 98.000 | NC(=O)c1cccnc1 | 1kg | 112441745
Niacinamide | Chem-Impex | 98-92-0 | MFCD00006395 | 122.127 | C6H6N2O | 98.000 | NC(=O)c1cccnc1 | 1kg | 112441745
Sigma Aldrich Fine Chemicals Biosciences Paracetamol European Pharmacopoeia (EP) Reference Standard | 103-90-2 | MFCD00002328 |
Paracetamol European Pharmacopoeia (EP) Reference Standard | Mol Wt: 151.16 | 103-90-2 | MFCD00002328 |
Medchemexpress LLC Lenalidomide-4-aminomethyl hydrochloride | 444289-05-8 | 90.9% | 309.75 | 50 MG
Lenalidomide-4-aminomethyl hydrochloride is a Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. It can be connected to a ligand for protein by a linker to form PROTAC.
- Cereblon (CRBN) ligand
- Used in the recruitment of CRBN protein
- Can be connected to a ligand for protein by a linker to form PROTAC
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Taprenepag | 752187-80-7 | 98.8% | 478.52 g/mol | C24H22N4O5S | 10 MG
Taprenepag is a potent, selective prostaglandin EP2 receptor agonist used as a research reagent to study EP2-mediated signaling. It displays low-nanomolar activity in human and rat assays, strong selectivity over other prostaglandin receptors, and is provided as a high-purity material for laboratory applications.
- Potent EP2 agonist with low-nanomolar activity.
- High selectivity versus other prostaglandin receptors.
- High purity suitable for research use (98.8%).
- Molecular weight 478.52 g/mol and formula C24H22N4O5S.
- Storage recommendations: -20°C under nitrogen; in solvent -80°C for 6 months or -20°C for 1 month.
- Supplied in small research quantities; verify package size with supplier.
Sigma Aldrich Fine Chemicals Biosciences Clozapine European Pharmacopoeia (EP) Reference Standard | 5786-21-0 | MFCD00153785 |
Clozapine European Pharmacopoeia (EP) Reference Standard | Mol Wt: 326.82 | 5786-21-0 | MFCD00153785 |
Apexbio Technology LLC Mesalamine 89-57-6 500mg
Mesalamine (89-57-6) is a small-molecule inhibitor targeting the I B kinase (IKK) signaling pathway It is designed to modulate the inflammatory response thereby regulating the NF- B pathway and the expression of pro-inflammatory mediators Mesalamine exerts its biological activity primarily through inhibition of cytokine-mediated activation of the NF- B pathway Based on these pharmacological properties mesalamine holds research potential in studies of inflammatory signaling cascades autoimmune conditions and related inflammatory disorders
Medchemexpress LLC Lenalidomide | 191732-72-6 | 99.94% | 25 MG
Lenalidomide (CC-5013) is a derivative of Thalidomide that acts as a molecular glue and is an orally active immunomodulator. It functions as a ligand of ubiquitin E3 ligase cereblon (CRBN), leading to the selective ubiquitination and degradation of lymphoid transcription factors IKZF1 and IKZF3 by the CRBN-CRL4 ubiquitin ligase.
- Inhibits growth of mature B-cell lymphomas, including multiple myeloma.
- Induces IL-2 release from T cells.
- Stimulates T cell proliferation, IFN-γ, and IL-2 production.
- Inhibits pro-inflammatory cytokines (TNF-α, IL-1, IL-6, IL-12) and elevates anti-inflammatory cytokine IL-10 from human PBMCs.
- Downregulates IL-6 production and augments myeloma cell apoptosis.
- Functions as a molecular glue between human E3 ubiquitin ligase cereblon and CKIα.
- Induces ubiquitination and degradation of this kinase, killing leukemic cells by p53 activation.