Acetylides
Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | MFCD30536167 | 98.0% | 392.44 g·mol-1 | C18H32O9 | 50 MG
Propargyl-PEG7-acid is a polyethylene glycol (PEG)-based linker with a terminal propargyl (alkyne) group and a carboxylic acid. It is used as a click-chemistry compatible linker for assembling PROTACs and antibody-drug conjugates, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach payloads or targeting moieties.
- Cleavable PEG linker suitable for PROTAC and ADC synthesis.
- Contains a terminal alkyne for CuAAC (click chemistry) conjugation.
- High purity supports reliable coupling reactions.
- Stable as a dry powder when stored under inert atmosphere at low temperature.
- Available in small research packs for medicinal chemistry use.
Medchemexpress LLC 4-pentynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 132178-37-1 | 99.8% | 195.17 g/mol | C9H9NO4 | 250 MG
Propargyl-C1-NHS ester is an N-hydroxysuccinimide (NHS) ester bearing a propargyl (alkyne) handle used as a non-cleavable linker and click-chemistry reagent for antibody-drug conjugation and general bioconjugation. It couples to primary amines via NHS-ester chemistry and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing partners.
- Alkyne-functional NHS ester for click chemistry
- Suitable for antibody-drug conjugation and bioconjugation workflows
- Reacts with primary amines via NHS ester coupling
- Compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC)
- High purity and available in multiple pack sizes, including 250 mg
- Soluble in DMSO; store sealed, away from moisture and light
eMolecules 1706428-65-0 | 2-Methyl-4-(trifluoromethoxy)-DL-phenylalanine | Apollo Scientific | MFCD22201062 | 263.216 | C11H12F3NO3 | 95.000 | Cc1cc(OC(F)(F)F)ccc1CC(N)C(O)=O | 1g | 562461290
2-Methyl-4-(trifluoromethoxy)-DL-phenylalanine | Apollo Scientific | 1706428-65-0 | MFCD22201062 | 263.216 | C11H12F3NO3 | 95.000 | Cc1cc(OC(F)(F)F)ccc1CC(N)C(O)=O | 1g | 562461290
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | ≥98.0% | 407.50 g/mol | C19H37NO8 | 1 G
Propargyl-PEG8-NH2 is a polyethylene glycol (PEG8) alkyne linker bearing a terminal primary amine. It is used as a non-cleavable linker in conjugation chemistry, including ADC and PROTAC synthesis, and as a click-chemistry building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Alkyne functional group for CuAAC click reactions.
- Terminal primary amine for conjugation and linker formation.
- High purity (≥98.0%).
- Molecular weight 407.50 g/mol.
- Chemical formula C19H37NO8.
- Available in multiple package sizes, including 1 G.
Medchemexpress LLC Propargyl-PEG8-bromide | 2055046-25-6 | 471.38 | C19H35BrO8 | 1 G
Propargyl-PEG8-bromide is a PEG-based heterobifunctional linker containing a terminal propargyl (alkyne) group and a bromide leaving group. It is intended for use in ADC and PROTAC linker construction and for click-chemistry bioconjugation.
- Heterobifunctional PEG linker with terminal alkyne and bromide.
- Molecular formula C19H35BrO8 and molecular weight 471.38.
- Used in ADC and PROTAC linker synthesis and alkyne-azide click chemistry.
- Supplied in small-scale packages, including 1 g.
- CAS number 2055046-25-6 for unambiguous identification.
Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | 348.39 g·mol⁻1 | C16H28O8 | 100 MG
Propargyl-PEG6-acid is a PEG-based linker bearing a terminal propargyl (alkyne) group, used as a click-chemistry reagent and as a linker in the synthesis of PROTACs and antibody-drug conjugates. The PEG6 spacer increases hydrophilicity and enables conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Contains a terminal propargyl (alkyne) functional group.
- Suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Used in synthesis of PROTACs and antibody-drug conjugates.
- PEG6 spacer provides hydrophilicity and improved solubility.
- Storage recommendations: pure form refrigerated or frozen for long-term stability; store solutions frozen.
Medchemexpress LLC 4-pentynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 132178-37-1 | 99.8% | 195.17 g/mol | C9H9NO4 | 1 G
Propargyl-C1-NHS ester is an alkyne-containing N-hydroxysuccinimide (NHS) ester used as a non-cleavable, amine-reactive linker for bioconjugation. It reacts with primary amines to form stable amide bonds and participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) for click chemistry applications.
- Alkyne-containing N-hydroxysuccinimide ester reactive toward primary amines.
- Copper-catalyzed azide-alkyne cycloaddition (CuAAC) for click chemistry.
- Forms stable amide bonds with amine-containing biomolecules.
- Suitable for antibody-drug conjugation and general bioconjugation workflows.
- Recommended storage: -20°C, sealed and protected from moisture and light.
- Molecular weight 195.17 g/mol; formula C9H9NO4; cas number 132178-37-1.
Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | ≥97.0% | 348.39 g/mol | C16H28O8 | 250 MG
Propargyl-PEG6-acid is a PEG-based linker and click chemistry reagent containing a terminal alkyne. It is used as a linker in PROTAC and ADC synthesis and for copper-catalyzed azide-alkyne cycloaddition (CuAAc) bioconjugation reactions.
- cleavable PEG6 linker suitable for PROTAC and ADC synthesis
- contains a terminal propargyl (alkyne) group for click chemistry
- high purity (≥97.0% by NMR) suitable for research applications
- molecular weight 348.39 g/mol, molecular formula C16H28O8
- storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC 2,5,8,11-Tetraoxatetradec-13-yne | 89635-82-5 | 98.0% | 202.25 | 1 G
Propargyl-PEG3-methane is a PEG-based PROTAC linker used in the synthesis of PROTACs. It also functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
Medchemexpress LLC Propargyl-PEG8-OH | 1351556-81-4 | 1 G
Propargyl-PEG8-OH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC (S)-VQW-765 ((S)-AQW-051) | 98.0% | 294.39 | 5 MG
(S)-VQW-765 ((S)-AQW-051) is an orally active, selective, and effective α7 nicotinic ACh receptor (nAChR) partial agonist. It has potential applications in cognitive disorders related to neurological diseases, such as Alzheimer's disease or schizophrenia.
- Orally active, selective, and effective α7 nAChR partial agonist
- Potential applications in cognitive disorders
- Suitable for neurological diseases like Alzheimer's or schizophrenia
![eMolecules 1826900-79-1 | 3-Fluorobicyclo[1.1.1]pentan-1-amine hydrochloride | Combi-Blocks, Inc. | MFCD28963742 | 137.580 | C5H9ClFN | 98.000 | Cl.NC12CC(F)(C1)C2 | 10g | 882683785](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000280248.jpg-250.jpg)
eMolecules 1826900-79-1 | 3-Fluorobicyclo[1.1.1]pentan-1-amine hydrochloride | Combi-Blocks, Inc. | MFCD28963742 | 137.580 | C5H9ClFN | 98.000 | Cl.NC12CC(F)(C1)C2 | 10g | 882683785
3-Fluorobicyclo[1.1.1]pentan-1-amine hydrochloride | Combi-Blocks, Inc. | 1826900-79-1 | MFCD28963742 | 137.580 | C5H9ClFN | 98.000 | Cl.NC12CC(F)(C1)C2 | 10g | 882683785