Acetylides
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | ≥98.0% | 407.50 g/mol | C19H37NO8 | 1 G
Propargyl-PEG8-NH2 is a polyethylene glycol (PEG8) alkyne linker bearing a terminal primary amine. It is used as a non-cleavable linker in conjugation chemistry, including ADC and PROTAC synthesis, and as a click-chemistry building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Alkyne functional group for CuAAC click reactions.
- Terminal primary amine for conjugation and linker formation.
- High purity (≥98.0%).
- Molecular weight 407.50 g/mol.
- Chemical formula C19H37NO8.
- Available in multiple package sizes, including 1 G.
Medchemexpress LLC Propargyl-PEG4-GGFG-DXd | 2762518-94-3 | MFCD01346226 | 100.0% | 1083.12 | C54H63FN8O15 | 100 MG
Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for antibody-drug conjugates (ADCs) that links an ADC linker to the DNA topoisomerase I inhibitor DXd and provides a propargyl handle for bioorthogonal conjugation.
- Molecular formula: C54H63FN8O15
- Molecular weight: 1083.12
- Cas number: 2762518-94-3
- Purity: 99.99%
- Appearance: solid, off-white to light yellow
- Storage: 4°C sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month
- Package size: available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg; larger sizes available by quote
Medchemexpress LLC Propargyl-PEG10-acid | 2055022-18-7 | 98.0% | 524.60 | 500 MG
Propargyl-PEG10-acid is a PEG derivative that features a propargyl group along with a terminal carboxylic acid. It functions as a click chemistry reagent, containing an Alkyne group, and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules that possess Azide groups.
- PEG derivative
- Features a propargyl group
- Contains a terminal carboxylic acid
- Functions as a click chemistry reagent
- Contains an alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Suitable for PROTAC synthesis
- Used as a biochemical assay reagent
Medchemexpress LLC Propargyl-PEG3-amine | 932741-19-0 | 98.0% | 187.24 | 100 MG
Propargyl-PEG3-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent that contains an alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
Medchemexpress LLC Propargyl-PEG6-alcohol | 944560-99-0 | 97.0% | 1 G
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Used in the synthesis of proteolysis targeting chimeras (PROTACs)
- Contains an alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
(C)C#C | 100g | 410166968](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000471113.jpg-250.jpg)
eMolecules 1066-54-2 | Ethynyltrimethylsilane | AA Blocks LLC | MFCD00008569 | 98.220 | C5H10Si | 0.000 | C[Si](C)(C)C#C | 100g | 410166968
Ethynyltrimethylsilane | AA Blocks LLC | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 0.000 | C[Si](C)(C)C#C | 100g | 410166968
eMolecules 59608-01-4 | 3-(Pyridin-3-yl)propiolic acid | MFCD02177466 | 1g
Ambeed | 3-(Pyridin-3-yl)propiolic acid | 1g | 588343019 | A625596 | 59608-01-4 | MFCD02177466 | 147.133 | C8H5NO2
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Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | >98.0% | 407.50 g/mol | C19H37NO8 | 10 MG
Propargyl-PEG8-NH2 is an alkyne-terminated polyethylene glycol (PEG8) amine linker used for bioconjugation and linker synthesis. It provides a terminal alkyne for click chemistry and a primary amine for further derivatization, with a PEG8 spacer to improve solubility and spacing between conjugated moieties.
- Provides a terminal alkyne group for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Contains a primary amine for amide formation and further functionalization.
- PEG8 spacer improves solubility and reduces steric hindrance.
- High chemical purity suitable for research applications.
- Colorless to light yellow liquid, convenient for solution-phase coupling reactions.
- Commonly used in PROTAC, ADC, and general bioconjugation workflows.
Medchemexpress LLC Propargyl-O-C1-amido-PEG4-C2-NHS ester | 2101206-92-0 | 95.0% | 458.46 g/mol | C20H30N2O10 | 10 MG
Propargyl-O-C1-amido-PEG4-C2-NHS ester is a propargyl-functionalized PEG4 spacer bearing an N-hydroxysuccinimide (NHS) ester. It is used as a bioconjugation reagent for click-chemistry and linker construction, and is reactive toward primary amines. Store cold and dry to preserve NHS ester reactivity.
- Propargyl (alkyne) functional group for click chemistry.
- NHS ester reactive toward primary amines for conjugation.
- Four-unit PEG spacer for increased solubility and spacing.
- Molecular weight 458.46 g/mol.
- Purity 95.0%.
- Recommended storage: pure form at -20°C; in solvent at -80°C or -20°C.
Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 | C10H16O5 | 250 MG
Propargyl-PEG3-acid is a PEG-based bifunctional linker featuring a terminal propargyl (alkyne) group and a carboxylic acid; it is used as a non-cleavable three-unit PEG linker for antibody-drug conjugates and as a PEG linker for PROTACs, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
- Non-cleavable three-unit PEG linker suitable for ADC and PROTAC synthesis.
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition for conjugation to azide-containing molecules.
- High purity appropriate for research-scale bioconjugation workflows.
- Available in multiple pack sizes to support small-scale and larger preparative work.
eMolecules 1206972-45-3 | 2-Chloro-5-(trifluoromethoxy)pyridine | MFCD18257007 | 1g
Ambeed | 2-((Tetrahydro-2H-pyran-4-yl)oxy)-5-(4455-tetramethyl-132-dioxaborolan-2-yl)benzonitrile | 100mg | 602852409 | A728926 | 1292317-54-4 | MFCD22393670 | 329.200 | C18H24BNO4
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Medchemexpress LLC Propargyl-PEG4-Br | 1308299-09-3 | 5 G
Propargyl-PEG4-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).
- Functions as a PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Acts as a non-cleavable ADC linker
- Utilized in the synthesis of antibody-drug conjugates (ADCs)
- Serves as a click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC (S)-VQW-765 ((S)-AQW-051) | 98.0% | 294.39 | 5 MG
(S)-VQW-765 ((S)-AQW-051) is an orally active, selective, and effective α7 nicotinic ACh receptor (nAChR) partial agonist. It has potential applications in cognitive disorders related to neurological diseases, such as Alzheimer's disease or schizophrenia.
- Orally active, selective, and effective α7 nAChR partial agonist
- Potential applications in cognitive disorders
- Suitable for neurological diseases like Alzheimer's or schizophrenia