Acetylides

Medchemexpress LLC Propargyl-PEG9-amine | 2093153-98-9 | 97.0% | 50 MG

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Propargyl-PEG9-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group.

• Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
• Reacts with molecules containing Azide groups

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Medchemexpress LLC Propargyl-PEG2-NHS ester | 2512228-06-5 | ≥98.0% | 269.25 g/mol | 100 MG

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This PEG-based linker is designed for the synthesis of proteolysis-targeting chimeras (PROTACs), which are molecules that utilize the ubiquitin-proteasome system to degrade target proteins. It functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.

• Functions as a linker in targeted protein degradation research.
• Acts as a click chemistry reagent.
• Contains an alkyne functional group for specific reactions.
• Can undergo copper-catalyzed azide-alkyne cycloaddition.
• Enables conjugation with azide-containing molecules.
• Offers high purity for reliable experimental results.

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Medchemexpress LLC N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) | 2112732-01-9 | > 96% | 519.58 | 250 MG

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N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• PEG-based PROTAC linker
• Can be used in the synthesis of PROTACs
• Click chemistry reagent
• Contains an Alkyne group
• Allows copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups

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eMolecules​ 1706428-65-0 | 2-Methyl-4-(trifluoromethoxy)-DL-phenylalanine | Apollo Scientific | MFCD22201062 | 263.216 | C11H12F3NO3 | 95.000 | Cc1cc(OC(F)(F)F)ccc1CC(N)C(O)=O | 1g | 562461290

2-Methyl-4-(trifluoromethoxy)-DL-phenylalanine | Apollo Scientific | 1706428-65-0 | MFCD22201062 | 263.216 | C11H12F3NO3 | 95.000 | Cc1cc(OC(F)(F)F)ccc1CC(N)C(O)=O | 1g | 562461290

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Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | MFCD30536167 | 98.0% | 392.44 g·mol-1 | C18H32O9 | 50 MG

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Propargyl-PEG7-acid is a polyethylene glycol (PEG)-based linker with a terminal propargyl (alkyne) group and a carboxylic acid. It is used as a click-chemistry compatible linker for assembling PROTACs and antibody-drug conjugates, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach payloads or targeting moieties.

• Cleavable PEG linker suitable for PROTAC and ADC synthesis.
• Contains a terminal alkyne for CuAAC (click chemistry) conjugation.
• High purity supports reliable coupling reactions.
• Stable as a dry powder when stored under inert atmosphere at low temperature.
• Available in small research packs for medicinal chemistry use.

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eMolecules​ 106-96-7 | 3-Bromo-1-Propyne(80% wt.in toluene) | AA Blocks LLC | MFCD00000241 | 118.961 | C3H3Br | 0.000 | BrCC#C | 100g | 586018241

3-Bromo-1-Propyne(80% wt.in toluene) | AA Blocks LLC | 106-96-7 | MFCD00000241 | 118.961 | C3H3Br | 0.000 | BrCC#C | 100g | 586018241

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eMolecules​ 1066-54-2 | Trimethylsilylacetylene | Combi-Blocks | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 100g | 267169362

Trimethylsilylacetylene | Combi-Blocks | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 100g | 267169362

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eMolecules​ 1066-54-2 | Trimethylsilylacetylene | Combi-Blocks | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 5g | 335349791

Trimethylsilylacetylene | Combi-Blocks | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 5g | 335349791

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eMolecules​ 1066-54-2 | Trimethylsilylacetylene | Combi-Blocks | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 25g | 267169361

Trimethylsilylacetylene | Combi-Blocks | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 25g | 267169361

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eMolecules​ 1240257-07-1 | 2-Fluoro-4-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | MFCD16652441 | 210.128 | C8H6F4O2 | 98.000 | OCc1ccc(OC(F)(F)F)cc1F | 1g | 562454556

2-Fluoro-4-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | 1240257-07-1 | MFCD16652441 | 210.128 | C8H6F4O2 | 98.000 | OCc1ccc(OC(F)(F)F)cc1F | 1g | 562454556

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eMolecules​ 764-37-4 | (E)-Pent-3-en-1-ol | Combi-Blocks, Inc. | MFCD07636756 | 86.134 | C5H10O | 95.000 | C\C=C\CCO | 10g | 854189544

(E)-Pent-3-en-1-ol | Combi-Blocks, Inc. | 764-37-4 | MFCD07636756 | 86.134 | C5H10O | 95.000 | C\C=C\CCO | 10g | 854189544

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eMolecules​ 927-74-2 | 3-Butyn-1-ol | Oakwood Chemicals | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 100g | 480108299

3-Butyn-1-ol | Oakwood Chemicals | 927-74-2 | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 100g | 480108299

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eMolecules​ 129676-67-1 | 2-Methyl-4-(trifluoromethoxy)phenol | Apollo Scientific | MFCD04972927 | 192.137 | C8H7F3O2 | 97.000 | Cc1cc(OC(F)(F)F)ccc1O | 1g | 562457673

2-Methyl-4-(trifluoromethoxy)phenol | Apollo Scientific | 129676-67-1 | MFCD04972927 | 192.137 | C8H7F3O2 | 97.000 | Cc1cc(OC(F)(F)F)ccc1O | 1g | 562457673

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Medchemexpress LLC Propargyl-O-C1-amido-PEG4-C2-NHS ester | 2101206-92-0 | 95.0% | 458.46 g/mol | C20H30N2O10 | 10 MG

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Propargyl-O-C1-amido-PEG4-C2-NHS ester is a propargyl-functionalized PEG4 spacer bearing an N-hydroxysuccinimide (NHS) ester. It is used as a bioconjugation reagent for click-chemistry and linker construction, and is reactive toward primary amines. Store cold and dry to preserve NHS ester reactivity.

• Propargyl (alkyne) functional group for click chemistry.
• NHS ester reactive toward primary amines for conjugation.
• Four-unit PEG spacer for increased solubility and spacing.
• Molecular weight 458.46 g/mol.
• Purity 95.0%.
• Recommended storage: pure form at -20°C; in solvent at -80°C or -20°C.

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Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 | C10H16O5 | 250 MG

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Propargyl-PEG3-acid is a PEG-based bifunctional linker featuring a terminal propargyl (alkyne) group and a carboxylic acid; it is used as a non-cleavable three-unit PEG linker for antibody-drug conjugates and as a PEG linker for PROTACs, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.

• Non-cleavable three-unit PEG linker suitable for ADC and PROTAC synthesis.
• Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition for conjugation to azide-containing molecules.
• High purity appropriate for research-scale bioconjugation workflows.
• Available in multiple pack sizes to support small-scale and larger preparative work.

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