Acetylides
Medchemexpress LLC Boc-propargylamine | 92136-39-5 | 99.5% | C8H13NO2 | 10 G
N-Boc-Propargylamine is a biochemical reagent used as a biological material or organic compound for life science-related research. It is a click chemistry reagent, containing an alkyne group, that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Used to prepare triazolobenzylidene-thiazolopyrimidines
- Acts as CDC25 phosphatase inhibitors
- Used for the synthesis of beta-glucan polysaccharide analogs
- Involved in the Pauson-Khand (PK) reaction to prepare 4,5-dissubstituted cyclopentenones
Medchemexpress LLC D(+)-Raffinose pentahydrate | 17629-30-0 | 594.51 | 5 G
D(+)-Raffinose pentahydrate is an orally active inhibitor of LecA (Kd = 32 μM) and GtfC. It functions by reducing cyclic diguanylate (c-di-GMP) through increased activity of a c-di-GMP specific phosphodiesterase and interferes with GTF function. This compound decreases IL-4 and IL-5 mRNA, exhibits biofilm-inhibitory activity against *Pseudomonas aeruginosa* and *Streptococcus mutans*, and inhibits allergic airway eosinophilia. It is intended for research use only and not for sale to patients.
- Orally active inhibitor of LecA and GtfC
- Reduces cyclic diguanylate (c-di-GMP)
- Interferes with GTF function
- Decreases IL-4 and IL-5 mRNA
- Exhibits biofilm-inhibitory activity against *Pseudomonas aeruginosa* and *Streptococcus mutans*
- Inhibits allergic airway eosinophilia
Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 g/mol | C10H16O5 | 5 G
Propargyl-PEG3-acid is a PEG-based bifunctional linker bearing a terminal propargyl (alkyne) group and a carboxylic acid. It is used in bioconjugation and medicinal chemistry applications such as click chemistry and PROTAC or ADC linker construction.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition
- Three-unit PEG spacer improves solubility and flexibility
- Carboxylic acid functionality enables standard coupling chemistries
- High purity (99.14%) and liquid form, colorless to light yellow
- Available in multiple sizes, including a 5 g package; recommended storage: -20°C for long-term stability
Medchemexpress LLC α-D-Glucopyranoside, β-D-fructofuranosyl O-α-D-galactopyranosyl-(1→6)-, hydrate (1:5) | 17629-30-0 | 594.51 | 1 ML
D(+)-Raffinose pentahydrate is an orally active inhibitor of LecA and GtfC. It reduces cyclic diguanylate (c-di-GMP) by increasing the activity of a c-di-GMP specific phosphodiesterase. This compound interferes with GTF function, decreases IL-4 and IL-5 mRNA, and inhibits allergic airway eosinophilia.
- Exhibits biofilm-inhibitory activity against Pseudomonas aeruginosa.
- Exhibits biofilm-inhibitory activity against Streptococcus mutans.
- Suppresses biofilm formation and reduces insoluble glucan production in Streptococcus mutans.
- Downregulates gtfB and gtfC gene expression.
- Alleviates allergen-induced airway eosinophilia in rats.
- Reduces IL-4 and IL-5 mRNA levels in lung tissue.
- Tends to lower alveolar macrophages, neutrophils, lymphocytes, and IgE levels.
Medchemexpress LLC Propargyl-PEG5-amine | 1589522-46-2 | MFCD27977505 | 98.9% | 275.34 g/mol | C13H25NO5 | 250 MG
Propargyl-PEG5-amine is a PEG-based linker reagent used as an alkyne functional handle for click chemistry and as a non-cleavable linker in ADC and PROTAC synthesis.
- PEG-based alkyne linker for conjugation and click chemistry.
- Non-cleavable linker suitable for ADC and PROTAC applications.
- Provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition.
- High purity and fully characterized by LCMS, HNMR, and RP-HPLC.
- Available in multiple pack sizes, including 250 MG.
- Colorless to light yellow liquid with a density of 1.049 g/cm3.
Medchemexpress LLC Propargyl-PEG8-NHS ester | 2182601-74-5 | MFCD31536764 | >95.0% | 533.57 g/mol | C24H39NO12 | 250 MG
Propargyl-PEG8-NHS ester is an amine-reactive polyethylene glycol (PEG) linker bearing a terminal propargyl (alkyne) group and an N-hydroxysuccinimide (NHS) activated ester. It is used for bioconjugation, click chemistry, and as a linker in ADC/PROTAC synthesis, providing improved solubility and site-selective attachment.
- Amine-reactive NHS ester for efficient conjugation to primary amines.
- Terminal propargyl alkyne enables copper-catalyzed or strain-promoted click reactions.
- PEG8 spacer improves solubility and reduces steric hindrance.
- High purity typically ≥95% for reliable biochemical use.
- Molecular weight approximately 533.57 g/mol, suitable for linker applications.
- Available as a 250 MG solid for laboratory-scale synthesis.
Medchemexpress LLC 5-(Boc-amino)-1-pentanol | 75178-90-4 | MFCD01862955 | ≥97.0% | 203.28 g/mol | C10H21NO3 | 10 G
5-(Boc-amino)-1-pentanol is a Boc-protected amino alcohol used as a versatile linker and building block in organic and medicinal chemistry. The tert-butoxycarbonyl (Boc) group protects the amine during multi-step syntheses, while the primary hydroxyl group enables subsequent functionalization and conjugation.
- Boc-protected amine for orthogonal protection strategies.
- Primary hydroxyl enables esterification and coupling reactions.
- High purity suitable for synthesis (≥97%).
- Available in multiple small-scale packages for research use.
- Compact molecular weight facilitates incorporation into small molecules.
eMolecules 2-Fluoro-4-(trifluoromethoxy)-DL-phenylalanine | 1391008-15-3 | MFCD16652500 | 1g
Apollo Scientific | 2-Fluoro-4-(trifluoromethoxy)-DL-phenylalanine | 1g | 562456457 | PC302801 | | 1391008-15-3 | MFCD16652500 | 267.180 | C10H9F4NO3
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Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | ≥98.0% | 392.44 | C18H32O9 | 250 MG
Propargyl-PEG7-acid is a PEG-based linker and click chemistry reagent containing a terminal alkyne that enables copper-catalyzed azide-alkyne cycloaddition. It is used as a PROTAC linker and as a cleavable linker in antibody-drug conjugate synthesis.
- Contains terminal alkyne suitable for CuAAc
- PEG7 spacer provides solubility and conformational flexibility
- Applicable as a cleavable linker for ADC synthesis
- High purity: ≥98.0% (NMR)
- Available in small-scale pack sizes for research use
Medchemexpress LLC N-Boc-Propargylamine | 92136-39-5 | >99.78% | C8H13NO2 | 50 G
N-Boc-Propargylamine is a biochemical reagent used in life science research. It functions as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Can be used as a biological material or organic compound
- Contains an Alkyne group for click chemistry reactions
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Used to prepare triazolobenzylidene-thiazolopyrimidines (CDC25 phosphatase inhibitors)
- Synthesizes beta-glucan polysaccharide analogs
- Involved in Pauson-Khand reaction to prepare 4,5-dissubstituted cyclopentenones
eMolecules 4-Fluoro-3-(trifluoromethoxy)phenol | 886501-26-4 | MFCD06660257 | 1g
Apollo Scientific | 4-Fluoro-3-(trifluoromethoxy)phenol | 1g | 562453217 | PC500166 | | 886501-26-4 | MFCD06660257 | 196.101 | C7H4F4O2
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