Acetylides
Medchemexpress LLC Propargyl-PEG10-acid | 2055022-18-7 | 98.0% | 524.60 | 250 MG
Propargyl-PEG10-acid is a PEG derivative containing a propargyl group with a terminal carboxylic acid. It functions as a click chemistry reagent, utilizing an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing azide groups.
- PEG derivative
- Contains a propargyl group
- Features a terminal carboxylic acid
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition with azide groups
![Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | MFCD19160595 | 99.6% | 143.18 g/mol | C7H13NO2 | 100 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202861.png-250.jpg)
Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | MFCD19160595 | 99.6% | 143.18 g/mol | C7H13NO2 | 100 G
Propargyl-PEG2-amine is a PEG-based bifunctional linker that contains a terminal propargyl (alkyne) group and a primary amine, designed for conjugation chemistry and synthetic applications such as antibody-drug conjugate (ADC) formation, PROTAC assembly, and click chemistry.
- PEG-2 spacer with terminal propargyl group
- Primary amine functional group for conjugation
- High purity suitable for synthesis (99.6%)
- Colorless to light yellow liquid; density 0.992 ± 0.06 g/cm3
- Compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC)
Medchemexpress LLC Propargyl-PEG5-Br | 1287660-83-6 | 339.22 | 100 MG
Propargyl-PEG5-Br is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Propargyl-PEG1-NHS ester | 1174157-65-3 | 98.9% | 225.20 g/mol | C10H11NO5 | 1 G
Propargyl-PEG1-NHS ester is a small polyethylene glycol (PEG1) linker bearing an N-hydroxysuccinimide (NHS) ester and a terminal propargyl (alkyne) group. It is designed to derivatize primary amines via NHS chemistry and to introduce an alkyne handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions, enabling bioconjugation and linker construction.
- Reactive NHS ester for conjugation to primary amines.
- Terminal alkyne (propargyl) enables CuAAC click chemistry.
- Small PEG1 spacer reduces steric hindrance and improves solubility.
- Typical assay purity reported around 98.9%.
- Stable when stored at -20°C in pure form for extended periods.
Medchemexpress LLC Propargyl-PEG3-bromide | 203740-63-0 | 97.7% | 251.12 | 500 MG
Propargyl-PEG3-bromide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Tert-butyl N-(5-hydroxypentyl)carbamate | 75178-90-4 | MFCD01862955 | >97.0% | 203.28 g·mol⁻1 | C10H21NO3 | 1 G
5-(Boc-amino)-1-pentanol is a Boc-protected 5-aminopentanol used as a versatile intermediate and linker in organic and medicinal chemistry. It contains a tert-butoxycarbonyl protected amine and a primary alcohol, enabling selective deprotection and further functionalization for synthesis of peptides, small molecules, and conjugates.
- Boc-protected amine enables selective deprotection workflows.
- Primary alcohol allows further derivatization and coupling reactions.
- High purity suitable for synthetic and medicinal chemistry applications.
- Defined storage stability in solvent and bulk formats.
- Useful as a linker for conjugation and building-block synthesis.
(C)C#C | 100g | 267169362](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000225185.jpg-250.jpg)
eMolecules 1066-54-2 | Trimethylsilylacetylene | Combi-Blocks | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 100g | 267169362
Trimethylsilylacetylene | Combi-Blocks | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 95.000 | C[Si](C)(C)C#C | 100g | 267169362
eMolecules 764-37-4 | (E)-Pent-3-en-1-ol | Combi-Blocks, Inc. | MFCD07636756 | 86.134 | C5H10O | 95.000 | C\C=C\CCO | 10g | 854189544
(E)-Pent-3-en-1-ol | Combi-Blocks, Inc. | 764-37-4 | MFCD07636756 | 86.134 | C5H10O | 95.000 | C\C=C\CCO | 10g | 854189544
Medchemexpress LLC Propargyl-O-C1-amido-PEG4-C2-NHS ester | 2101206-92-0 | 95.0% | 458.46 g/mol | C20H30N2O10 | 10 MG
Propargyl-O-C1-amido-PEG4-C2-NHS ester is a propargyl-functionalized PEG4 spacer bearing an N-hydroxysuccinimide (NHS) ester. It is used as a bioconjugation reagent for click-chemistry and linker construction, and is reactive toward primary amines. Store cold and dry to preserve NHS ester reactivity.
- Propargyl (alkyne) functional group for click chemistry.
- NHS ester reactive toward primary amines for conjugation.
- Four-unit PEG spacer for increased solubility and spacing.
- Molecular weight 458.46 g/mol.
- Purity 95.0%.
- Recommended storage: pure form at -20°C; in solvent at -80°C or -20°C.
Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 | C10H16O5 | 250 MG
Propargyl-PEG3-acid is a PEG-based bifunctional linker featuring a terminal propargyl (alkyne) group and a carboxylic acid; it is used as a non-cleavable three-unit PEG linker for antibody-drug conjugates and as a PEG linker for PROTACs, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
- Non-cleavable three-unit PEG linker suitable for ADC and PROTAC synthesis.
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition for conjugation to azide-containing molecules.
- High purity appropriate for research-scale bioconjugation workflows.
- Available in multiple pack sizes to support small-scale and larger preparative work.
Medchemexpress LLC Propargyl-PEG8-acid | 2055014-94-1 | 98.0% | 436.49 g/mol | C20H36O10 | 1 G
Propargyl-PEG8-acid is a polyethylene glycol (PEG) based linker bearing a terminal propargyl (alkyne) group and a carboxylic acid, used for conjugation in PROTAC and antibody-drug conjugate (ADC) synthesis.
- Contains a terminal propargyl alkyne for click chemistry.
- Provides a carboxylic acid handle for amide coupling.
- Approximate molecular weight 436.49 g/mol.
- High purity (98.0%) suitable for research applications.
- Available in multiple pack sizes, including 1 G for lab-scale use.
Medchemexpress LLC Propargyl-PEG7-NHS ester | 2093152-77-1 | MFCD29041936 | >95.0% | 489.51 g/mol | C22H35NO11 | 1 G
Propargyl-PEG7-NHS ester is an alkyne-functional PEG7 N-hydroxysuccinimide (NHS) ester used as a bifunctional linker for bioconjugation. It couples to primary amines via NHS chemistry and provides a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition, making it suitable for ADC, PROTAC, and general labeling applications.
- Alkyne-functional terminal enables click chemistry.
- NHS ester reacts with primary amines for covalent coupling.
- PEG7 spacer increases solubility and provides flexibility.
- Molecular weight about 489.51 g/mol and formula C22H35NO11.
- Typical applications include ADC linkers, PROTAC synthesis, and peptide or protein labeling.