Hydrobromides
Medchemexpress LLC (RS)-AMPA hydrobromide | 171259-81-7 | MFCD00055183 | 99.5% | 267.08 g/mol | C7H11BrN2O4 | 1 MG
(RS)-AMPA hydrobromide is the racemic hydrobromide salt of AMPA, a selective agonist of AMPA-type ionotropic glutamate receptors. It is intended for research use in receptor pharmacology, electrophysiology, and biochemical assays that require a water-soluble AMPA agonist.
- Selective AMPA receptor agonist for glutamatergic signaling studies.
- Hydrobromide salt form improves water solubility.
- High purity suitable for analytical and biological experiments.
- Available in small milligram pack sizes for laboratory use.
- Applicable to electrophysiology, pharmacology, and biochemical assays.
Medchemexpress LLC Guvacoline hydrobrom 25mg | 17210-51-4 | 25 MG
Guvacoline hydrobromide is the hydrobromide salt of guvacoline, a pyridine alkaloid found in Areca triandra. It is used as a research reagent and functions as a weak full agonist of atrial and ileal muscarinic acetylcholine receptors (mAChR).
- Acts as a weak full agonist of atrial and ileal muscarinic receptors.
- White to off-white solid physical form.
- Molecular formula C7H12BrNO2 and molecular weight 222.08.
- Purity typically around 96.09% by HPLC.
- Store sealed at 4°C and protect from moisture and light; in solution store at -80°C for long-term.
- Supplied in small milligram pack sizes for laboratory research.
Medchemexpress LLC NAN-190 hydrobromide | 115338-32-4 | 99.1% | 474.39 | 100 MG
NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist and a selective antagonist of 5-HT1A. It is intended for research use only.
- Appearance: Solid
- Color: Light yellow to yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 100 MG
Eletriptan hydrobromide is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, exhibiting Ki values of 0.92 nM and 3.14 nM, respectively. It is intended for research use only. In vivo studies have shown that eletriptan hydrobromide dose-dependently reduces carotid blood flow in anesthetized dogs and inhibits dural plasma protein extravasation in anesthetized rats.
- Functions as a 5-HT1B and 5-HT1D receptor agonist.
- Exhibits Ki values of 0.92 nM for 5-HT1B receptor.
- Exhibits Ki values of 3.14 nM for 5-HT1D receptor.
- Dose-dependently reduces carotid blood flow in anesthetized dogs.
- Inhibits dural plasma protein extravasation in anesthetized rats.
- Completely inhibits plasma protein extravasation from the dura mater at 100 μg/kg.
Medchemexpress LLC Burixafor (hydrobromide) | 1191450-19-7 | 98.0% | 769.01 | 50 MG
Burixafor hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. It inhibits CXCL12 binding to CXCR4, antagonizes Gαᵢ and β-arrestin2 recruitment, and blocks downstream Gαᵢ-mediated effects on cAMP signal transduction. This compound mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) for research on autologous hematopoietic stem cell transplantation (ASCT).
- Potent CXCR4 antagonist with a pIC50 of 7.4.
- Inhibits CXCL12 binding to CXCR4.
- Antagonizes CXCL12-induced Gαᵢ and β-arrestin2 recruitment.
- Blocks downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction.
- Mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC).
- Useful for research on autologous hematopoietic stem cell transplantation (ASCT).
Medchemexpress LLC Dihydro-β-erythroidine hydrobromide | 29734-68-7 | >98.0% | 356.25 g·mol⁻¹ | C16H22BrNO3 | 5 MG
Dihydro-β-erythroidine hydrobromide is a research reagent that acts as a competitive antagonist of neuronal nicotinic acetylcholine receptors, with preferential activity at α4β2 and α4β4 subtypes. Supplied as the hydrobromide salt, it is used in electrophysiology, receptor pharmacology, and in vivo studies to selectively inhibit nAChR-mediated responses.
- High purity (≥98% by HPLC).
- Selective antagonist for α4β2 and α4β4 nicotinic receptors.
- Suitable for in vitro and in vivo pharmacology studies.
- Supplied as hydrobromide salt for improved stability and solubility.
- Available in small research package sizes (1 mg, 5 mg, 10 mg).
- Documented identifiers include CAS 29734-68-7 and molecular weight 356.25 g·mol⁻¹.
Medchemexpress LLC Darifenacin hydrobromide | 133099-07-7 | 99.78% | C28H31BrN2O2 | 100 MG
Darifenacin hydrobromide (UK-88525) is a selective and orally active antagonist of the M3 muscarinic receptor (M3R) with a pKi of 8.9. It exhibits over 20-fold greater specificity for M3R compared to other muscarinic receptors. This compound is utilized in research for studying urinary incontinence and other symptoms associated with overactive bladder. Additionally, Darifenacin hydrobromide has demonstrated inhibitory effects on tumor growth in colorectal cancer cells and possesses anti-tumor properties.
- Selective M3 muscarinic receptor antagonist
- Over 20-fold greater specificity for M3R
- Used in research for urinary incontinence and overactive bladder symptoms
- Demonstrates inhibitory effects on tumor growth in colorectal cancer cells
- Possesses anti-tumor properties
Medchemexpress LLC Oxidopamine (hydrobromide) | 636-00-0 | 99.4% | 200 MG
Oxidopamine (hydrobromide) | 636-00-0 | 99.4% | 200 MG
Medchemexpress LLC (RS)-AMPA hydrobromide | 171259-81-7 | MFCD00055183 | 99.5% | 267.08 g·mol⁻¹ | C7H11BrN2O4 | 5 MG
(RS)-AMPA hydrobromide is a research-grade glutamate analogue that acts as a potent, selective agonist of AMPA-type ionotropic glutamate receptors. Supplied as a solid hydrobromide salt with high purity, it is intended for use in neuropharmacology, electrophysiology, and receptor pharmacology studies. The compound is soluble in DMSO and water (sonication recommended) and should be stored protected from moisture under refrigerated or low-temperature conditions as specified by the supplier.
- Potent, selective agonist of AMPA receptors.
- Hydrobromide salt increases aqueous solubility.
- High purity suitable for research and analytical applications.
- Soluble in DMSO and water; sonication recommended.
- Stable when stored sealed and protected from moisture.
- Provided in small milligram quantities for experimental use.
Apexbio Technology LLC A 61603 hydrobromide 107756-30-9 5mg
A 61603 hydrobromide (CAS 107756-30-9) is a potent and highly selective agonist of the 1A-adrenergic receptor one of the 1-adrenergic receptor subtypes involved in cellular growth and proliferation Compared to its activity at 1B- and 1D-adrenergic receptors A 61603 demonstrates approximately 35-fold higher potency for 1A-AR In cellular assays it robustly induces phosphoinositide hydrolysis in 1A-AR-expressing fibroblasts (pEC50 8 24) and in neonatal rat cardiomyocytes it increases calcium transient frequency in a dose-dependent manner (EC50 6 9 nM) In vascular models A 61603 markedly elevates perfusion pressure demonstrating significantly greater efficacy than noradrenaline This compound serves as a valuable tool for delineating 1A-AR-mediated signaling and vascular regulation
Medchemexpress LLC Arecoline | 63-75-2 | MFCD00005704 | 1 ML
Arecoline is a naturally occurring psychoactive alkaloid that is brain-penetrant and orally active. It acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors. This compound has been observed to exhibit stimulation, alertness, anxiolysis, and anti-parasitic effects, though it can also induce oxidative stress.
- Purity: 99.84%
- Molecular weight: 155.19
- Formula: C8H13NO2
- Appearance: liquid
- Color: light yellow to brown
- Structure classification: alkaloids, piperidine alkaloids
- Acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors
- Induces stimulation, alertness, anxiolysis, and anti-parasitic effects
- Can alleviate anxiety and depression in CFA-induced mice
Medchemexpress LLC Carbamimidothioic acid, C,C'-(1,4-phenylenedi-2,1-ethanediyl) ester, hydrobromide (1:2) | 157254-60-9 | 98.0% | C12H20Br2N4S2 | 10MG
1,4-PBIT (dihydrobromide) is the dihydrobromide salt of the small-molecule 1,4-PBIT, supplied for research use. The compound is documented by manufacturer COA and SDS, and is provided as a white to off-white solid with molecular formula C12H20Br2N4S2, molecular weight 444.25, and reported purity 98.0%.
- 98.0% purity as reported on the certificate of analysis
- White to off-white solid form for solid-handling workflows
- Molecular formula C12H20Br2N4S2 and molecular weight 444.25
- Recommended storage: in solvent -80°C (6 months) or -20°C (1 month), sealed
- Used as a nitric oxide synthase inhibitor in research applications
Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 1 G
Pifithrin-α hydrobromide is a chemical compound known for its role as a p53 inhibitor, effectively blocking its transcriptional activity and preventing apoptosis in cells. Additionally, it functions as an aryl hydrocarbon receptor (AhR) agonist.
- Purity of 98.58%
- Appears as a solid, white to light yellow in color
- Recommended storage at 4°C, sealed and away from moisture; in solvent at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at concentrations ≥ 50 mg/mL
- Targets p53 and aryl hydrocarbon receptor (AhR)
- Suppresses p53 protein transcription and inhibits p53-dependent apoptosis
- Acts as a potent AhR agonist, inducing DNA binding complex formation
Medchemexpress LLC Arecoline | 63-75-2 | 100 MG
Arecoline is a naturally brain-penetrant and orally active psychoactive alkaloid. It functions as a partial agonist of nicotinic and muscarinic acetylcholine receptors. It has been observed to exhibit stimulation, alertness, anxiolysis, and anti-parasitic effects. Research indicates it can also induce oxidative stress.
- Partial agonist of nicotinic and muscarinic acetylcholine receptors
- Exhibits stimulation and alertness
- Demonstrates anxiolysis and anti-parasitic effects
- Induces generation of reactive oxygen species
- Causes cell cycle arrest at G1/G0 phase in HaCaT cells
- Upregulates hemeoxygenase-1, ferritin light chain, glucose-6-phosphate dehydrogenase, glutamate-cysteine ligase catalytic subunit, and glutathione reductase expression
- Alleviates anxiety and depression in CFA-induced mice
Medchemexpress LLC Pifithrin-α (hydrobromide) | 63208-82-2 | C16H19BrN2OS | 50 MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist.
- Blocks p53 transcriptional activity.
- Prevents cells from apoptosis.
- Acts as an aryl hydrocarbon receptor (AhR) agonist.
- Suppresses glucose oxidase (GOX)-induced p53 protein increase.
- Reduces Bcl-2 protein and prevents Bax increase.
- Up-regulates the classic AhR target gene CYP1A1.
- Demonstrates in vivo efficacy in reducing aortic rupture and normalizing aortic morphology in Foxe3-/- mice.