Hydrobromides
Medchemexpress LLC Pifithrin-α (hydrobromide) | 63208-82-2 | C16H19BrN2OS | 50 MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist.
- Blocks p53 transcriptional activity.
- Prevents cells from apoptosis.
- Acts as an aryl hydrocarbon receptor (AhR) agonist.
- Suppresses glucose oxidase (GOX)-induced p53 protein increase.
- Reduces Bcl-2 protein and prevents Bax increase.
- Up-regulates the classic AhR target gene CYP1A1.
- Demonstrates in vivo efficacy in reducing aortic rupture and normalizing aortic morphology in Foxe3-/- mice.
Medchemexpress LLC Vortioxetine hydrobromide | 960203-27-4 | C18H23BrN2S | 5 MG
Vortioxetine hydrobromide is a multimodal serotonergic agent that acts as an antagonist of 5-HT3A and 5-HT7 receptors and an inhibitor of 5-hydroxytryptamine transporter (SERT). It also functions as a 5-HT1A agonist and a partial 5-HT1B agonist. This product is intended for research use only and has not been fully validated for medical applications.
- Antagonist of 5-HT3A and 5-HT7 receptors
- Inhibitor of 5-hydroxytryptamine transporter (SERT)
- 5-HT1A agonist and partial 5-HT1B agonist
- Multimodal serotonergic agent
- Increases cell proliferation and cell survival
- Stimulates maturation of immature granule cells
- Does not cause cognitive or psychomotor impairment
Apexbio Technology LLC SR 95531 hydrobromide 104104-50-9 5mg
SR 95531 hydrobromide (CAS 104104-50-9) also known as Gabazine is a selective competitive antagonist of the GABAA receptor By binding to the GABA recognition site on the receptor it blocks the activation induced by -aminobutyric acid (GABA) Experimental studies report an inhibitory concentration (IC50) of approximately 0 2 M for GABAA receptor-mediated responses Widely utilized in neuroscience research Gabazine is applied to investigate the physiological and pathological roles of GABAA receptor-mediated synaptic transmission neural network modulation and neurotransmitter regulation
Medchemexpress LLC Amthamine dihydrobromide | 142457-00-9 | MFCD00673891 | 99.6% | 319.07 g·mol⁻¹ | C6H13Br2N3S | 5 MG
Amthamine dihydrobromide is the dihydrobromide salt of amthamine, a selective histamine receptor agonist used in pharmacology and receptor research. It is supplied as a purified solid for use in in vitro and in vivo assays to probe histamine receptor function and signaling.
- High reported purity: 99.6%.
- Molecular weight 319.07 g·mol⁻¹.
- Supplied as a solid dihydrobromide salt.
- Suitable for histamine receptor pharmacology and assay work.
- Available in small milligram pack sizes for research use.
Medchemexpress LLC Pifithrin-β hydrobromide | 511296-88-1 | 100.0% | 349.29 | 50 MG
Pifithrin-β hydrobromide, also known as PFT β hydrobromide, is a potent p53 inhibitor with an IC50 of 23 μM. It is related to Pifithrin-α, a lead compound for cancer and neurodegenerative disease therapy, which rapidly converts to Pifithrin-β, its N-acetyl derivative. Pretreatment with 1 and 10 μM pifithrin-β has shown neuroprotective effects.
- Potent p53 inhibitor
- Exerts neuroprotective effects
- Used in cancer and neurodegenerative disease research
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 50 MG
Halofuginone hydrobromide (Standard) is an analytical standard derived from Febrifugine, functioning as a competitive prolyl-tRNA synthetase inhibitor. It also acts as a specific inhibitor of type-I collagen synthesis, reducing osteoarthritis symptoms by suppressing TGF-β activity. Additionally, it is a potent pulmonary vasodilator, enhancing Kv channels and blocking various calcium channels, and is commonly used in qualitative, quantitative, and methodological research experiments.
- Intended for research and analytical applications
- Attenuates osteoarthritis
- Activates Kv channels
- Blocks voltage-gated, receptor-operated, and store-operated calcium channels
- Has anti-malaria effects
- Has anti-inflammatory effects
- Has anti-cancer effects
- Has anti-fibrosis effects
- Used in HPLC, GC, and MS research
Medchemexpress LLC S-(2-aminoethyl) methanethiosulfonate hydrobromide | 16599-33-0 | ≥95.0% | 10 MG
MTSEA hydrobromide is a sulfhydryl-reactive reagent used to modify free cysteine residues in proteins and peptides, introducing a positively charged side chain approximately the size of lysine. Supplied as the hydrobromide salt, it is commonly used in biochemical and chemical biology experiments to probe cysteine accessibility and study structure-function relationships.
- Reacts selectively with free cysteine residues to form a positively charged adduct.
- Introduces a side chain similar in size to lysine for functional and structural probing.
- Suitable for cysteine labeling, accessibility mapping, and structure-function studies.
- Provided as a hydrobromide salt for improved stability and handling.
- Available in small milligram quantities for research-scale experiments.
Cayman Chemical Clobenpropit hydrobromide
A selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes); reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by (R)-α-methylhistamine at 0.3, 0.1, and 3 nM; decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice at 1 and 3 mg/kg, an effect that can be blocked by (R)-α-methylhistamine or imetit; increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons at 0.1 μM
Medchemexpress LLC Pyrithiamine hydrobromide | 534-64-5 | 96.6% | 10MG
Pyrithiamine hydrobromide | 534-64-5 | 96.6% | 10MG
TARGETMOL CHEMICALS INC TAZEMETOSTAT HYDROBROMID 100MG
Also available in 2 mg 5 mg 10 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50 392 nM). purity: 99%
Medchemexpress LLC m-tyramine hydrobromide | 38449-59-1 | 98.5% | 218.09 g·mol-1 | C8H12BrNO | 5 MG
m-Tyramine hydrobromide is the hydrobromide salt of m-tyramine, an endogenous trace amine neuromodulator reported to interact with adrenergic and dopaminergic receptors. It is supplied for research and analytical applications, with reported analytical purity and supporting documentation for use as a reference standard.
- Endogenous trace amine neuromodulator with adrenergic and dopaminergic activity.
- Analytical grade with high purity suitable for research and standards.
- Available in multiple small-scale pack sizes and as a solution in DMSO.
- Supplied with certificate of analysis and RP-HPLC documentation.
- Useful as a reference standard and biochemical research reagent.
eMolecules 62595-74-8 | 3-Bromopiperidine-2,6-dione | Synthonix | MFCD11053059 | 192.012 | C5H6BrNO2 | 97.000 | BrC1CCC(=O)NC1=O | 250mg | 534611341
3-Bromopiperidine-2,6-dione | Synthonix | 62595-74-8 | MFCD11053059 | 192.012 | C5H6BrNO2 | 97.000 | BrC1CCC(=O)NC1=O | 250mg | 534611341
Medchemexpress LLC Carbamimidothioic acid, C,C'-(1,4-phenylenedi-2,1-ethanediyl) ester, hydrobromide (1:2) | 157254-60-9 | 98.0% | C12H20Br2N4S2 | 10MG
1,4-PBIT (dihydrobromide) is the dihydrobromide salt of the small-molecule 1,4-PBIT, supplied for research use. The compound is documented by manufacturer COA and SDS, and is provided as a white to off-white solid with molecular formula C12H20Br2N4S2, molecular weight 444.25, and reported purity 98.0%.
- 98.0% purity as reported on the certificate of analysis
- White to off-white solid form for solid-handling workflows
- Molecular formula C12H20Br2N4S2 and molecular weight 444.25
- Recommended storage: in solvent -80°C (6 months) or -20°C (1 month), sealed
- Used as a nitric oxide synthase inhibitor in research applications
Medchemexpress LLC Halofuginone (hydrobromide) | 64924-67-0 | MFCD00946455 | 100.0% | 495.59 g/mol | C16H18Br2ClN3O3 | 10 MG
Halofuginone hydrobromide is the hydrobromide salt of halofuginone, a febrifugine-derived small molecule that competitively inhibits prolyl-tRNA synthetase and is supplied for research applications studying fibrosis, inflammation, malaria, and cancer. It is provided as a white to off-white solid with high purity and defined storage and solvent recommendations.
- Hydrobromide salt for improved handling and solubility.
- Competitive prolyl-tRNA synthetase inhibitor used in mechanistic research.
- High purity suitable for research applications.
- White to off-white solid, soluble in DMSO (≈50 mg/mL) and water (≈2.6 mg/mL).
- Store sealed and away from moisture; in solution keep at -80°C for long-term stability.
- Applicable for preclinical studies of fibrosis, inflammation, malaria, and cancer pathways.
Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 1 G
Pifithrin-α hydrobromide is a chemical compound known for its role as a p53 inhibitor, effectively blocking its transcriptional activity and preventing apoptosis in cells. Additionally, it functions as an aryl hydrocarbon receptor (AhR) agonist.
- Purity of 98.58%
- Appears as a solid, white to light yellow in color
- Recommended storage at 4°C, sealed and away from moisture; in solvent at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at concentrations ≥ 50 mg/mL
- Targets p53 and aryl hydrocarbon receptor (AhR)
- Suppresses p53 protein transcription and inhibits p53-dependent apoptosis
- Acts as a potent AhR agonist, inducing DNA binding complex formation