Hydrobromides
Cayman Chemical Clobenpropit hydrobromide
A selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes); reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by (R)-α-methylhistamine at 0.3, 0.1, and 3 nM; decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice at 1 and 3 mg/kg, an effect that can be blocked by (R)-α-methylhistamine or imetit; increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons at 0.1 μM
Medchemexpress LLC Arecoline hydrobromide | 300-08-3 | 99.95% | 1 ML
Arecoline hydrobromide is a naturally brain-penetrant and orally active psychoactive alkaloid. It acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors, exhibiting properties such as stimulation, alertness, anxiolysis, and anti-parasitic effects. It can also induce oxidative stress. This compound is for research use only.
- Acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors
- Exhibits stimulation, alertness, anxiolysis, and anti-parasitic effects
- Can induce oxidative stress
- Brain-penetrant and orally active
- Induces reactive oxygen species generation and G1/G0 phase cell cycle arrest in HaCaT cells
- Upregulates stress-responsive genes
- Alleviates anxiety and depression in CFA-induced mice
Medchemexpress LLC Fatostatin hydrobromide | 298197-04-3 | MFCD00760867 | 99.5% | C18H19BrN2S | 10 MM 1 ML
Fatostatin hydrobromide | 298197-04-3 | MFCD00760867 | 99.5% | C18H19BrN2S | 10 MM 1 ML
Medchemexpress LLC SCH-202676 hydrobromide | 265980-25-4 | 96.81% | 348.26 | 1 MG
SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). It exhibits antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 μM.
- Allosteric modulator of G protein-coupled receptors (GPCRs)
- Allosteric modulator of adenosine receptor (AR)
- Antiviral activity
- Inhibits 3CLpro in a time-dependent manner
- IC50 value of 0.655 μM against 3CLpro
Medchemexpress LLC Fatostatin hydrobromide (125B11 hydrobromide) | 298197-04-3 | 99.5% | C18H19BrN2S | 1 G
Fatostatin hydrobromide (125B11 hydrobromide) | 298197-04-3 | 99.5% | C18H19BrN2S | 1 G
Active Motif Arecoline hydrobromide
Active Motif's Arecoline hydrobromide is an inhibitor of acetyl-CoA acetyltransferase 1 (ACAT1). Tyrosine 407 phosphorylation activates mitochondrial acetyl-CoA ACAT1 by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is "hijacked" and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50 = 11.1 uM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. It is an agonist at muscarinic acetylcholine receptors M1-M5 (EC50 in the range of 7-410 nM), and may be involved in dementia.
Active Motif Arecoline hydrobromide
Active Motif's Arecoline hydrobromide is an inhibitor of acetyl-CoA acetyltransferase 1 (ACAT1). Tyrosine 407 phosphorylation activates mitochondrial acetyl-CoA ACAT1 by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is "hijacked" and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50 = 11.1 uM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. It is an agonist at muscarinic acetylcholine receptors M1-M5 (EC50 in the range of 7-410 nM), and may be involved in dementia.
Medchemexpress LLC Arecoline hydrobromide | 300-08-3 | 99.9% | 100 MG
Arecoline hydrobromide is a naturally brain-penetrant and orally active psychoactive alkaloid. It functions as a partial agonist of nicotinic and muscarinic acetylcholine receptors, exhibiting stimulation, alertness, anxiolysis, and anti-parasitic effects. It can also induce oxidative stress.
- Acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors
- Exhibits stimulation, alertness, anxiolysis, and anti-parasitic effects
- Induces generation of reactive oxygen species and cell cycle arrest in HaCaT cells
- Up-regulates stress-responsive genes
- Alleviates anxiety and depression in CFA-induced mice
Medchemexpress LLC 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide | 300-08-3 | 99.95% | 1 G
Arecoline hydrobromide is a naturally occurring psychoactive alkaloid that is brain-penetrant and orally active. It acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors. It exhibits stimulation, alertness, anxiolysis, and anti-parasitic effects, and can also induce oxidative stress. It is intended for research use only.
- Acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors.
- Exhibits stimulation, alertness, anxiolysis, and anti-parasitic effects.
- Can induce oxidative stress.
- Induces reactive oxygen species generation and G1/G0 phase cell cycle arrest in HaCaT cells.
- Alleviates anxiety and depression in CFA-induced mice.
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 5 MG
Halofuginone hydrobromide is an analytical standard of Halofuginone (hydrobromide) for research and analytical applications. This Febrifugine derivative is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It specifically inhibits type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibiting TGF-β activity. Furthermore, it acts as a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Competitive prolyl-tRNA synthetase inhibitor
- Specific inhibitor of type-I collagen synthesis
- Attenuates osteoarthritis by inhibiting TGF-β activity
- Functions as a potent pulmonary vasodilator
- Possesses anti-malaria effects
- Exhibits anti-inflammatory effects
- Demonstrates anti-cancer effects
- Shows anti-fibrosis effects
TARGETMOL CHEMICALS INC TAZEMETOSTAT HYDROBROMID 100MG
Also available in 2 mg 5 mg 10 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50 392 nM). purity: 99%
TARGETMOL CHEMICALS INC FATOSTATIN HYDROBROMIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2. purity: 99%