Hydrobromides
TARGETMOL CHEMICALS INC TC-E 5003 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 uM. Purity 97.01%
Medchemexpress LLC Burixafor hydrobromide | 1191450-19-7 | 98.0% | 769.01 | C27H51N8O3P·5/2 HBr | 10 MG
Burixafor hydrobromide is the hydrobromide salt of burixafor, a selective, orally active CXCR4 antagonist supplied as a research reagent for preclinical and in vitro studies of CXCR4-mediated biology, including cancer metastasis, angiogenesis, and hematopoietic stem cell mobilization.
- Selective CXCR4 antagonist for receptor-targeted studies.
- High purity (98.0%) suitable for research applications.
- Water soluble (≈50 mg/mL) with ultrasonic assistance.
- Solid, light yellow to yellow appearance for easy handling.
- Recommended storage at -20°C under nitrogen for stability.
- Available in small research quantity (10 MG).
Medchemexpress LLC Halofuginone (hydrobromide) | 64924-67-0 | 495.59 | 1 ML
Halofuginone hydrobromide (RU-19110 hydrobromide), a Febrifugine derivative, acts as a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It specifically inhibits type-I collagen synthesis and reduces osteoarthritis (OA) by inhibiting TGF-β activity. Additionally, it functions as a potent pulmonary vasodilator through the activation of Kv channels and the blocking of voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM)
- Inhibits type-I collagen synthesis
- Reduces osteoarthritis (OA) by inhibiting TGF-β activity
- Potent pulmonary vasodilator through Kv channel activation
- Blocks voltage-gated, receptor-operated, and store-operated Ca2+ channels
- Exhibits anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 1 ML
Eletriptan hydrobromide is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, primarily used as a laboratory chemical for research purposes. It appears as an off-white to light brown solid with a molecular weight of 463.43.
- 5-HT1B and 5-HT1D receptor agonist
- Demonstrates antimigraine activity
- Ki values of 0.92 nM for 5-HT1B receptor
- Ki values of 3.14 nM for 5-HT1D receptor
- Off-white to light brown solid appearance
- Reduces carotid blood flow in anesthetized dogs (in vivo)
- Inhibits dural plasma protein extravasation in anesthetized rats (in vivo)
Medchemexpress LLC Scopolamine hydrobromide trihydrate | 6533-68-2 | MFCD00150066 | 99.9% | 438.31 | 100 MG
Scopolamine hydrobromide trihydrate is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. It acts as a competitive antagonist of 5-HT3 receptors. This compound can induce cognitive and memory deficits in animals and is used in research.
- High-affinity muscarinic antagonist
- Crosses the blood-brain barrier
- Competitive antagonist of 5-HT3 receptors
- Induces cognitive and memory deficits in animals
- Used in research for preventing postoperative nausea and vomiting
- Used in research for motion sickness
- Used in research for nervous system diseases
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 50 MG
Eletriptan hydrobromide (Eletriptan HBr) is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, with Ki values of 0.92 nM and 3.14 nM, respectively. It is for research use only and not sold to patients.
- 5-HT1B and 5-HT1D receptor agonist
- Antimigraine activity
Medchemexpress LLC Burixafor hydrobromide | 1191450-19-7 | 98.0% | 769.01 | 100 MG
Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. It inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood and can be used for research on autologous hematopoietic stem cell transplantation (ASCT).
- Potent CXCR4 antagonist with a pIC50 of 7.4
- Inhibits CXCL12 binding to CXCR4
- Antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2
- Blocks downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction
- Mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) from bone marrow to peripheral blood
- Can be used for research on autologous hematopoietic stem cell transplantation (ASCT)
Medchemexpress LLC Burixafor hydrobromide | 1191450-19-7 | 98.0% | 769.01 | 500 MG
Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. It inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34+ hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood.
- Can be used for research on autologous hematopoietic stem cell transplantation (ASCT).
- Potent CXCR4 antagonist.
- Inhibits CXCL12 binding to CXCR4.
- Blocks Gαᵢ-mediated inhibitory effect on cAMP signal transduction.
- Mobilizes CD34+ hematopoietic stem/progenitor cells.
Medchemexpress LLC Remodelin (hydrobromide) | 1622921-15-6 | 99.6% | 363.28 | 25 MG
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. It inhibits NAT10 activity, slows DNA replication, and suppresses the growth of prostate cancer cells. This compound has been shown to inhibit the growth of prostate cancer and hepatocellular carcinoma in xenograft models, and enhances healthspan in a Hutchinson-Gilford Progeria Syndrome (HGPS) mouse model.
- Orally active and selective NAT10 inhibitor
- Inhibits NAT10 activity and slows DNA replication
- Suppresses growth of prostate cancer cells
- Inhibits growth of prostate cancer and hepatocellular carcinoma in xenograft models
- Enhances healthspan in HGPS mouse model
TARGETMOL CHEMICALS INC Galanthamine hydrobromide
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors. Purity 99.19%
Medchemexpress LLC Arecoline | 63-75-2 | 50 MG
Arecoline is a naturally occurring, brain-penetrant, and orally active psychoactive alkaloid. It acts as a partial agonist of both nicotinic and muscarinic acetylcholine receptors. It has been observed to induce stimulation, alertness, anxiolysis, and anti-parasitic effects, and can also induce oxidative stress.
- Naturally brain-penetrant and orally active psychoactive alkaloid.
- Partial agonist of nicotinic and muscarinic acetylcholine receptors.
- Exhibits stimulation, alertness, anxiolysis, and anti-parasitic effects.
- High purity: 99.84%.
Medchemexpress LLC Scopolamine hydrobromide trihydrate | 6533-68-2 | MFCD00150066 | 99.86% | 438.31 | 50 MG
Scopolamine hydrobromide trihydrate, also known as Hyoscine hydrobromide trihydrate, is a potent muscarinic antagonist capable of crossing the blood-brain barrier. It competitively antagonizes 5-HT3 receptors with an IC50 of 2.09 μM. This compound has been observed to induce cognitive and memory deficits in animals. It is currently being investigated for its potential applications in the prevention of postoperative nausea and vomiting, motion sickness, and nervous system diseases.
- High-affinity muscarinic antagonist.
- Able to cross the blood-brain barrier.
- Competitively antagonizes 5-HT3 receptors.
- Used in research for preventing postoperative nausea and vomiting.
- Used in research for motion sickness.
- Used in research for nervous system diseases.
Medchemexpress LLC Remodelin hydrobromide | 1622921-15-6 | 99.6% | 363.28 | 1 ML
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10, which inhibits NAT10 activity and slows DNA replication.
- Suppresses the growth of prostate cancer cells.
- Inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft models.
- Enhances the healthspan in a Hutchinson-Gilford progeria syndrome (HGPS) mouse model.
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | MFCD08141806 | 463.43 g/mol | C22H27BrN2O2S | 10 MG
Eletriptan hydrobromide is the hydrobromide salt of eletriptan, a selective 5-HT1B and 5-HT1D receptor agonist supplied as an analytical standard for laboratory and research use.
- Analytical standard suitable for research and assay development.
- Selective 5-HT1B and 5-HT1D agonist for pharmacology studies.
- Reported Ki values: 0.92 nM (5-HT1B) and 3.14 nM (5-HT1D).
- Chemical formula C22H27BrN2O2S; molecular weight ~463.4 g/mol.
- Provided in small masses appropriate for analytical work.
Medchemexpress LLC NAN-190 hydrobromide | 115338-32-4 | 99.1% | 474.39 | 10 MG
NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist, specifically a selective antagonist of 5-HT1A receptors. It is primarily used for research purposes and has been shown to reverse the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats.
- Serotonin receptor 5-HT antagonist
- Selective antagonist of 5-HT1A receptor
- Reverses catalepsy-improving effect of fluoxetine
- For research use only