Hydrobromides
Medchemexpress LLC Pifithrin-α hydrobromide | 63208-82-2 | C16H19BrN2OS | 25 MG
Pifithrin-α hydrobromide is a p53 inhibitor that blocks its transcriptional activity and prevents cells from apoptosis. It also acts as an aryl hydrocarbon receptor (AhR) agonist.
- Suppresses p53 protein transcription
- Prevents glucose oxidase (GOX)-induced p53 protein increase, Bcl-2 protein reduction, and Bax increase
- Inhibits p53-dependent apoptosis
- Acts as a potent AhR agonist, activating reporter activity, and up-regulating the AhR target gene CYP1A1
- Reduces the percentage of annexin V-positive Foxe3-/- SMCs
- Significantly reduces the incidence of aortic rupture and intramural hematomas
- Normalizes aortic diameter and TUNEL-positive cells in surviving Foxe3-/- animals
Cayman Chemical Clobenpropit hydrobromide
A selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes); reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by (R)-α-methylhistamine at 0.3, 0.1, and 3 nM; decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice at 1 and 3 mg/kg, an effect that can be blocked by (R)-α-methylhistamine or imetit; increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons at 0.1 μM
Medchemexpress LLC Pyrithiamine hydrobromide | 534-64-5 | 96.6% | 100 MG
Pyrithiamine hydrobromide is the hydrobromide salt of pyrithiamine, a thiamine metabolic inhibitor used in biochemical research. It serves as a substrate for thiamine pyrophosphokinase and is applied in studies of thiamine metabolism and nervous system disorders.
- Thiamine metabolic inhibitor used in biochemical research.
- Acts as a substrate for thiamine pyrophosphokinase.
- Useful in research on nervous system diseases and vitamin B1 metabolism.
- Chemical formula C14H20Br2N4O, molecular weight 420.14 g/mol.
- Supplied with high purity (≈96.6%).
- Available in small research quantities, including 100 mg.
Medchemexpress LLC Darifenacin hydrobromide | 133099-07-7 | 99.8% | C28H31BrN2O2 | 5 MG
Darifenacin hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist. It is used in the study of urinary incontinence and other symptoms of overactive bladder, and has demonstrated anti-tumor effects by inhibiting tumor growth in colorectal cancer cells. In vitro, it inhibits Kv currents and the phosphorylation of p38, ERK1/2, and Akt. In vivo studies showed antitumor effects in xenograft mouse models and decreased afferent activity in rat bladders.
- Selective and orally active M3 muscarinic receptor antagonist
- Used in the study of urinary incontinence and overactive bladder symptoms
- Exhibits anti-tumor effects in colorectal cancer cells
- Inhibits Kv currents in coronary arterial smooth muscle cells
- Decreases afferent activity of bladder Aδ and C fibers in female rats
Medchemexpress LLC Fatostatin hydrobromide (125B11 hydrobromide) | 298197-04-3 | 99.5% | C18H19BrN2S | 200 MG
Fatostatin hydrobromide (125B11 hydrobromide) is a specific inhibitor of SREBP activation that impairs the activation of SREBP-1 and SREBP-2. It binds to SCAP (SREBP cleavage-activating protein) and inhibits the ER-Golgi translocation of SREBPs.
- Impairs the activation of SREBP-1 and SREBP-2
- Binds to SCAP (SREBP cleavage-activating protein)
- Inhibits ER-Golgi translocation of SREBPs
- Decreases transcription of lipogenic genes in cells
- Possesses antitumor properties
- Lowers hyperglycemia in ob/ob mice
- For research use only
Medchemexpress LLC S-EIT hydrobromide 25g
S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research
Apexbio Technology LLC Arecoline hydrobromide 300-08-3 1g
Arecoline hydrobromide (CAS 300-08-3) is a nicotinic alkaloid that acts as a partial agonist at muscarinic acetylcholine receptors M1 M4 In electrophysiological studies it significantly inhibits the hERG potassium channel current with an IC50 of 9 55 mol/L The compound s inhibitory effect on IhERG displays concentration time and voltage dependency with blockade intensity influenced by stimulation frequency Subcutaneous administration in mice yields an LD50 of 100 mg/kg Arecoline hydrobromide is utilized in research on cardiac electrophysiology and muscarinic receptor pharmacology particularly for investigating frequency- and state-dependent modulation of cardiac ion channels
Apexbio Technology LLC TC-E 5003 17328-16-4 50mg
TC-E 5003 (CAS 17328-16-4) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) exhibiting an IC50 of 1 5 M1 PRMT1 a member of the PRMT family mediates post-translational arginine methylation and is implicated in regulating diverse cellular processes Aberrant PRMT1 activity has been associated with a range of malignancies making it of interest for oncology research In cellular studies TC-E 5003 has been shown to inhibit proliferation and induce apoptosis in MCF7a breast cancer and LNCaP prostate cancer cell lines as well as attenuate androgen-induced gene expression in LNCaP cells This compound serves as a useful tool for investigating PRMT1 function and its role in cancer biology
Medchemexpress LLC Pifithrin-β hydrobromide | 511296-88-1 | 99.9% | 349.29 | 1 ML
Pifithrin-β hydrobromide is a potent p53 inhibitor with an IC50 of 23 μM. It is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α, an inhibitor of the p53 protein, is unstable in culture medium and quickly converts to pifithrin-β. Studies show that pretreatments with 1 and 10 μM pifithrin-β can exert neuroprotective effects after 24 hours.
- Potent p53 inhibitor with an IC50 of 23 μM.
- Regarded as a lead compound for cancer and neurodegenerative disease therapy.
- Exerts neuroprotective effects.
Medchemexpress LLC Rociletinib hydrobromide | 1446700-26-0 | MFCD28386290 | 98.0% | 636.46 g/mol | C27H29BrF3N7O3 | 10 MG
Rociletinib hydrobromide is the hydrobromide salt of rociletinib, an orally active kinase inhibitor selective for mutant forms of the epidermal growth factor receptor (EGFR) including T790M. It is supplied as a solid research reagent for biochemical, cellular, and analytical studies.
- Hydrobromide salt of rociletinib.
- Selective inhibitor of mutant EGFR, including T790M.
- Intended for research and analytical applications.
- Purity 98.04% (HPLC).
- Molecular weight 636.46 g/mol.
- CAS number 1446700-26-0.
- Store sealed, away from moisture; in solvent: -80°C (6 months) or -20°C (1 month).
eMolecules 62595-74-8 | 3-Bromopiperidine-2,6-dione | Ambeed | MFCD11053059 | 192.012 | C5H6BrNO2 | 97.000 | BrC1CCC(=O)NC1=O | 250mg | 506392068
3-Bromopiperidine-2,6-dione | Ambeed | 62595-74-8 | MFCD11053059 | 192.012 | C5H6BrNO2 | 97.000 | BrC1CCC(=O)NC1=O | 250mg | 506392068
Medchemexpress LLC Arecoline hydrobromide | 300-08-3 | 99.95% | 500 MG
Arecoline hydrobromide is a naturally occurring, brain-penetrant, and orally active psychoactive alkaloid. It functions as a partial agonist for both nicotinic and muscarinic acetylcholine receptors, influencing various neurological processes. This compound has been noted for its ability to induce stimulation, alertness, anxiolysis, and anti-parasitic effects, though it can also cause oxidative stress.
- Naturally occurring psychoactive alkaloid
- Brain-penetrant and orally active
- Acts as a partial agonist of nicotinic and muscarinic acetylcholine receptors
- Can induce stimulation, alertness, anxiolysis, and anti-parasitic effects
- Induces reactive oxygen species and cell cycle arrest in HaCaT cells
- Alleviates anxiety and depression in CFA-induced mice
Medchemexpress LLC SCH-202676 (hydrobromide) | 265980-25-4 | 96.8% | 348.26 | 1 ML
SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). It demonstrates antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 μM.
- Purity: 96.81%
- Appearance: Solid
- Color: White to off-white
- Solubility: DMSO: 10 mg/mL
Medchemexpress LLC Remodelin (hydrobromide) | 1622921-15-6 | 99.6% | 363.28 | 500 MG
Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. It inhibits NAT10 activity, slows DNA replication, and suppresses the growth of prostate cancer cells. It also inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft models. Additionally, it enhances the healthspan in a Hutchinson-Gilford Progeria Syndrome (HGPS) mouse model.
- Orally active and selective inhibitor of acetyltransferase NAT10.
- Inhibits NAT10 activity.
- Slows DNA replication.
- Suppresses growth of prostate cancer cells.
- Inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft model.
- Enhances healthspan in Hutchinson-Gilford Progeria Syndrome (HGPS) mouse model.
AdipoGen 2 3-Diaminopropane-1-thiol HBr
Chemical. CAS 70548-07-1. Formula C3H10N2S . 2HBr. MW 106.2 . 161.8. Synthetic Building block for synthesis.