Hydrobromides
Medchemexpress LLC Halofuginone (hydrobromide) | 64924-67-0 | 495.59 | 1 ML
Halofuginone hydrobromide (RU-19110 hydrobromide), a Febrifugine derivative, acts as a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It specifically inhibits type-I collagen synthesis and reduces osteoarthritis (OA) by inhibiting TGF-β activity. Additionally, it functions as a potent pulmonary vasodilator through the activation of Kv channels and the blocking of voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM)
- Inhibits type-I collagen synthesis
- Reduces osteoarthritis (OA) by inhibiting TGF-β activity
- Potent pulmonary vasodilator through Kv channel activation
- Blocks voltage-gated, receptor-operated, and store-operated Ca2+ channels
- Exhibits anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 500 MG
Halofuginone hydrobromide is a Febrifugine derivative and a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibiting TGF-β activity. It also acts as a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM).
- Specific inhibitor of type-I collagen synthesis.
- Attenuates osteoarthritis (OA) by inhibition of TGF-β activity.
- Potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Has anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects.
Medchemexpress LLC Homatropine Bromide | 51-56-9 | 99.9% | 1 ML
Homatropine Bromide is an orally active muscarinic acetylcholine receptor antagonist. It functions as an anticholinergic agent and is intended for research applications only. This product is provided as a 10 mM solution in DMSO.
- Orally active muscarinic acetylcholine receptor antagonist
- Functions as an anticholinergic agent
- Provided as a 10 mM solution in DMSO
- Purity of 99.9%
- Suitable for research applications
Medchemexpress LLC Pifithrin-β hydrobromide | 511296-88-1 | MFCD02683960 | >=98.0% | 349.29 g/mol | C16H17BrN2S | 10 MG
Pifithrin-β hydrobromide is a small-molecule inhibitor of the p53 pathway supplied as the hydrobromide salt. It reversibly blocks p53 transcriptional activity (reported IC50 = 23 μM) and is used as a research tool in cellular and biochemical studies of apoptosis and ferroptosis. Chemical formula C16H17BrN2S; molecular weight 349.29 g/mol; CAS 511296-88-1.
- Reversible p53 inhibitor with reported IC50 of 23 μM.
- Hydrobromide salt for improved solubility and handling.
- Reported high purity (≥98% by HPLC) in supplier listings.
- Suitable for cellular and biochemical assays studying apoptosis and ferroptosis.
- Store sealed at 4 °C as a solid; in solution store at -80 °C for long-term stability.
Apexbio Technology LLC BD 1047 dihydrobromide 138356-21-5 10mg
BD 1047 dihydrobromide (CAS 138356-21-5) is a selective antagonist of the sigma-1 ( 1) receptor exhibiting Ki values of 0 93 nM for 1 and 47 nM for sigma-2 ( 2) receptors Sigma receptors distinct from opioid receptors include 1 and 2 subtypes and are implicated in modulating dopaminergic neurotransmission and drug-related behaviors In preclinical models BD 1047 dihydrobromide attenuates haloperidol- and DTG-induced dystonia and reverses cocaine-induced behavioral responses without affecting responses to natural rewards Additionally it alleviates mechanical allodynia in neuropathic pain models and modulates spinal 1 receptor and NR1 subunit expression This compound is utilized to investigate 1 receptor function in neuropharmacology and pain research
Medchemexpress LLC S-EIT hydrobromide 25g
S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research
Medchemexpress LLC Scopolamine hydrobromide trihydrate | 6533-68-2 | MFCD00150066 | 99.9% | 438.31 | 100 MG
Scopolamine hydrobromide trihydrate is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. It acts as a competitive antagonist of 5-HT3 receptors. This compound can induce cognitive and memory deficits in animals and is used in research.
- High-affinity muscarinic antagonist
- Crosses the blood-brain barrier
- Competitive antagonist of 5-HT3 receptors
- Induces cognitive and memory deficits in animals
- Used in research for preventing postoperative nausea and vomiting
- Used in research for motion sickness
- Used in research for nervous system diseases
TARGETMOL CHEMICALS INC Immethridine dihydrobromide
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Immethridine dihydrobromide is a novel, highly potent and selective histamine H3 receptor (H3R) agonist that inhibits dendritic cell function and alleviates experimental autoimmune encephalomyelitis.Immethridine dihydrobromide MesV induces depolarization of neurons and the MMN and prevents cardiorenal and renal injury. injury. Purity 98.16%
Cayman Chemical Clobenpropit hydrobromide
A selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes); reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by (R)-α-methylhistamine at 0.3, 0.1, and 3 nM; decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice at 1 and 3 mg/kg, an effect that can be blocked by (R)-α-methylhistamine or imetit; increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons at 0.1 μM
Medchemexpress LLC Arecoline | 63-75-2 | 50 MG
Arecoline is a naturally occurring, brain-penetrant, and orally active psychoactive alkaloid. It acts as a partial agonist of both nicotinic and muscarinic acetylcholine receptors. It has been observed to induce stimulation, alertness, anxiolysis, and anti-parasitic effects, and can also induce oxidative stress.
- Naturally brain-penetrant and orally active psychoactive alkaloid.
- Partial agonist of nicotinic and muscarinic acetylcholine receptors.
- Exhibits stimulation, alertness, anxiolysis, and anti-parasitic effects.
- High purity: 99.84%.