Hydrochlorides
Medchemexpress LLC L-778123 hydrochloride | 253863-00-2 | 99.9% | 442.34 | 50 MG
L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I, with IC50 values of 2 nM and 98 nM respectively. It is intended for research use only.
- Dual inhibitor of FPTase and GGPTase-I.
- Exhibits IC50 values of 2 nM for FPTase and 98 nM for GGPTase-I.
- Alone, it does not show obvious cytotoxicity on HT-29 and A549 cell lines (IC50: >100 μM), but can generate synergistic effects with Doxorubicin.
- Inhibits myeloid leukemia cell proliferation with IC50 values ranging from 0.2 μM to 1.8 μM for cell lines, and 0.1 μM to 161.8 μM in primary samples.
- Inhibits H-RAS prenylation in HL-60 cells and phosphorylated MEK-1/2 levels.
- Inhibits lymphocyte activation and function in human PBMCs.
Medchemexpress LLC YM-298198 hydrochloride | 1216398-09-2 | MFCD08703122 | 98.0% | 378.92 g/mol | C18H23ClN4OS | 50 MG
YM-298198 hydrochloride is the hydrochloride salt of YM-298198, a selective, orally active, non-competitive antagonist of metabotropic glutamate receptor 1 (mGluR1). Supplied as a solid research-grade reagent, it is used in pharmacology studies and neurological disease models.
- Selective mGluR1 antagonist for receptor pharmacology studies.
- Orally active and non-competitive mechanism of action.
- Supplied as a solid hydrochloride salt for stability and handling.
- Molecular formula C18H23ClN4OS and molecular weight 378.92 g/mol.
- High purity suitable for research applications.
Medchemexpress LLC RS-25344 hydrochloride | 152815-28-6 | 99.9% | 411.80 | 10 MM/1 ML
RS-25344 hydrochloride | 152815-28-6 | 99.9% | 411.80 | 10 MM/1 ML
Medchemexpress LLC DRP1i27 dihydrochloride | 1453028-33-5 | C20H28Cl2N6O | 100 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1 (0-50 μM).
- Increases cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner.
- Exhibits a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay.
Medchemexpress LLC Pazopanib hydrochloride | 635702-64-6 | 100.0% | 50 MG
Pazopanib hydrochloride is the hydrochloride salt of pazopanib, a small-molecule multi-target tyrosine kinase inhibitor active against VEGFR1/2/3, PDGFRβ, c-Kit, and FGFR1. It is supplied as a research reagent for in vitro pharmacology, cell-based assays, and preclinical studies.
- High purity suitable for research applications.
- Available as solid and DMSO solution formats for flexible use.
- Useful for kinase inhibition, cell signaling, and oncology research.
- Offered in multiple pack sizes to support screening and preclinical work.
![Medchemexpress LLC 3,6-diazabicyclo[3.2.2]nonane, 3-[(4-methyl-1h-imidazol-5-yl)methyl] (dihydrochloride) | 1453028-33-5 | 98.6% | 439.38 g/mol | C20H28Cl2N6O | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286113.png-250.jpg)
Medchemexpress LLC 3,6-diazabicyclo[3.2.2]nonane, 3-[(4-methyl-1h-imidazol-5-yl)methyl] (dihydrochloride) | 1453028-33-5 | 98.6% | 439.38 g/mol | C20H28Cl2N6O | 10 MG
DRP1i27 dihydrochloride is a research-grade small-molecule inhibitor of dynamin-related protein 1 (Drp1), provided as the dihydrochloride salt for laboratory studies of mitochondrial fission and related cellular processes.
- Potent inhibitor of Drp1 GTPase activity demonstrated in cell models.
- Supplied as a dihydrochloride salt suitable for biochemical and cellular assays.
- Available in multiple quantities and formats, including solid and 10 mM DMSO solutions.
- High purity: 98.6% (reported by manufacturer).
- Molecular formula C20H28Cl2N6O; molecular weight 439.38 g/mol.
- Documentation available: datasheet, COA, SDS, and spectral data for QC support.
Medchemexpress LLC GW405833 hydrochloride | 1202865-22-2 | 99.6% | 483.82 | 10 MG
GW405833 hydrochloride | 1202865-22-2 | 99.6% | 483.82 | 10 MG
Sigma Aldrich Fine Chemicals Biosciences Terbinafine hydrochloride | 78628-80-5 | MFCD00145430 | 250MG
Terbinafine hydrochloride | Purity: >=98% (HPLC) | Mol Wt: 327.89 | 78628-80-5 | MFCD00145430 | 250MG
Sigma Aldrich Fine Chemicals Biosciences o-Phenylenediamine dihydrochloride tablet, 1 mg substrate per tablet | 615-28-1 | MFCD00012966 | 100TAB
o-Phenylenediamine dihydrochloride tablet, 1 mg substrate per tablet | Mol Wt: 181.06 | 615-28-1 | MFCD00012966 | 100TAB
eMolecules 1938-62-1 | N,n,n',n'-tetramethyl-1,10-decanediamine | ChemScene | MFCD10686653 | 228.424 | C14H32N2 | 95.000 | CN(C)CCCCCCCCCCN(C)C | 250mg | 632307564
N,n,n',n'-tetramethyl-1,10-decanediamine | ChemScene | 1938-62-1 | MFCD10686653 | 228.424 | C14H32N2 | 95.000 | CN(C)CCCCCCCCCCN(C)C | 250mg | 632307564
Medchemexpress LLC Doxapram hydrochloride hydrate | 7081-53-0 | 99.3% | 25 MG
Doxapram hydrochloride hydrate | 7081-53-0 | 99.3% | 25 MG
Chem-Impex International, Inc. 2-Aminoethylmethylsulfone Hydrochloride | 104458-24-4 | MFCD03840162 | 1G
2-Aminoethylmethylsulfone Hydrochloride, 104458-24-4, MFCD03840162, 1G
Sigma Aldrich Fine Chemicals Biosciences Terbinafine Hydrochloride | 78628-80-5 | MFCD00145430 | 100mg
Terbinafine Hydrochloride | Mol Wt: 327.89 | 78628-80-5 | MFCD00145430 | 100mg
Selleck Chemical LLC Duloxetine HCl S2084-10mg
Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4 6 nM used for treatment of major depressive disorder and generalized anxiety disorder (GAD)
Selleck Chemical LLC Duloxetine S5071-1g
Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake