Hydrochlorides
Medchemexpress LLC Verubulin hydrochloride | 917369-31-4 | 98.7% | 50 MG
Verubulin hydrochloride is the hydrochloride salt of verubulin (MPC-6827), a quinazoline-derived microtubule polymerization inhibitor with reported antitumor activity. It is supplied as a solid research reagent for preclinical studies investigating microtubule dynamics and anticancer mechanisms.
- Hydrochloride salt suitable for enhanced solubility in polar solvents.
- Potent microtubule polymerization inhibitor used in anticancer research.
- Reported to be brain-penetrant, enabling neurobiology applications.
- High purity typical for analytical and preclinical work (98.7%).
- Stable as a solid at 4°C; follow recommended storage conditions for solutions.
Medchemexpress LLC Terbinafine hydrochloride | 78628-80-5 | 99.9% | 327.89 | 500 MG
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. It is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. It also demonstrates antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine hydrochloride functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent antifungal agent
- Orally active
- Inhibits squalene epoxidase from Candida
- Demonstrates antibacterial activity against certain Gram-positive and Gram-negative bacteria
- Functions as a click chemistry reagent with an Alkyne group
- Exhibits primary fungicidal action against most fungal pathogens
- Effective topically and orally in experimental dermatophytoses
Apexbio Technology LLC RS 127445 199864-87-4 10mM (in 1mL DMSO)
RS 127445 (CAS 199864-87-4) is a highly selective antagonist of the serotonin 5-HT2B receptor displaying nanomolar affinity (pKi 9 5 pIC50 10 4) and approximately 1000-fold selectivity over other receptor subtypes By inhibiting 5-HT2B-mediated signaling RS 127445 suppresses serotonin-induced increases in inositol phosphate and intracellular calcium in cellular models In vivo administration in rat models reduces stress- and TNBS-induced visceral hypersensitivity and attenuates colonic motility responses RS 127445 is widely used to elucidate 5-HT2B receptor functions in neurogastroenterology and mechanisms of gastrointestinal hypersensitivity
Medchemexpress LLC Benzamil hydrochloride | 161804-20-2 | 99.7% | 5 MG
Benzamil hydrochloride, an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor with an IC50 of approximately 100 nM. It also functions as a non-selective blocker of Deg/epithelial sodium channels (ENaC) and can enhance myogenic vasoconstriction. It inhibits TRPP3-mediated Ca2+-activated currents with an IC50 of 1.1 μM.
- Inhibits neuronal and heterologously expressed small conductance Ca2+-activated K-channels.
- Treatment with the compound (0.7 mg/kg/day; s.c.) resulted in an average survival until 16.1 weeks of age in stroke-prone spontaneously hypertensive rats (SHRSP).
Medchemexpress LLC TAS-103 dihydrochloride | 174634-09-4 | 98.5% | 406.31 | 50 MG
TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
- Dual inhibitor of DNA topoisomerase I/II.
- Active on CCRF-CEM cells with an IC50 value of 5 nM.
- Significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells.
- Highly cytotoxic to Lewis lung carcinoma (LLC) cells.
- Inhibits the viability of HeLa cells with an IC50 of 40 nM.
- Disrupts signal recognition particle (SRP) complex formation and induces destabilization of SRP14 and SRP19.
- Causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells without obvious body weight loss.
- Liposomal TAS-103 is more active than free TAS-103 in vivo.
Medchemexpress LLC Azepexole (hydrochloride) | 147663-20-5 | MFCD35200177 | >98.0% | 217.7 g/mol | C9H16ClN3O | 5 MG
Azepexole hydrochloride is the hydrochloride salt of azepexole (B-HT 933), a selective α2-adrenoceptor agonist used as a research reagent to study adrenergic receptor pharmacology and related physiological effects such as analgesia and antitussive responses.
- Selective α2-adrenoceptor agonist used in receptor pharmacology studies.
- Reported purity greater than 98% (HPLC).
- Molecular formula C9H16ClN3O and molecular weight 217.7 g/mol.
- Provided as a small-scale research pack suitable for laboratory experiments.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC DRP1i27 dihydrochloride | 1453028-33-5 | C20H28Cl2N6O | 1 MG
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Potent inhibitor of human Drp1
- Binds to the GTPase site of Drp1
- Targets mitochondrial fission in cell line models
- Offers protection against simulated ischemia-reperfusion injury
Medchemexpress LLC (±)-Bepridil hydrochloride hydrate | 74764-40-2 | 99.9% | 421.02 | 25 MG
Bepridil hydrochloride hydrate is a non-selective, long-acting calcium channel antagonist and sodium, potassium channel inhibitor. It exhibits antianginal and type I antiarrhythmic effects, and also functions as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. This product is intended for research on cardiovascular disorders.
- Non-selective calcium channel antagonist
- Long-acting
- Sodium channel inhibitor
- Potassium channel inhibitor
- Antianginal effects
- Type I antiarrhythmic effects
- Cardiac Na+/Ca2+ exchange (NCX1) inhibitor
- Blockades of Ca2+-dependent action potentials in vascular smooth muscle
- Blocks Ca currents and Na currents
- Decreases IKs under blockade of IKr
- Exhibits a half-life of averages 33±15 hours after single-dose administration
Cayman Chemical Terbinafine hydrochloride
A broad-spectrum antifungal agent; has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml); selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively); induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and HUVECs from 90-120 μM
Medchemexpress LLC Bestatin hydrochloride | 65391-42-6 | 99.9% | 1 ML
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, primarily employed in cancer research. It demonstrates significant effects on cell differentiation, proliferation, and enzymatic activities both in vitro and in vivo.
- Inhibits CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase.
- Enhances ATRA-induced differentiation in ATRA-sensitive APL NB4 cells.
- Inhibits ATRA-driven phosphorylation of p38 MAPK.
- Slows cell cycle progression, reduces cell growth, and decreases cell division frequency.
- Significantly reduces CD13 expression in diabetic mice.
- Inhibits expression of VEGF and heparanase in diabetic mice.
- Increases the number of splenocytes producing hemolytic anti-SRBC antibodies in vivo.
Medchemexpress LLC Bay-6672 hydrochloride | 2247520-31-4 | 98.0% | C26H28BrCl2N3O3 | 10MG
BAY-6672 hydrochloride is a potent, selective antagonist of the human Prostaglandin F (FP) receptor (reported IC50 ≈ 11 nM). It is used as a research reagent to probe FP receptor signaling and pharmacology and has demonstrated in vivo efficacy in preclinical lung fibrosis models. The compound is supplied as a solid with high reported purity.
- Potent FP receptor antagonism (IC50 ≈ 11 nM).
- Demonstrated in vivo efficacy in preclinical lung fibrosis models.
- Selective for FP over related prostaglandin receptors in published assays.
- High reported purity (~98.0%), suitable for biochemical studies.
- Provided as a solid research reagent for pharmacology and mechanistic assays.
Medchemexpress LLC DCPT1061 hydrochloride | 2289726-31-2 | 99.9% | 375.72 | 5 MG
DCPT1061 hydrochloride is a compound that exhibits a strong inhibitory effect on PRMT1, PRMT6, and PRMT8 in vitro, with little inhibitory effect on epigenetic enzymes such as PRMT3, PRMT4, and PRMT5. It also demonstrates antitumor effects.
- Selective inhibition: Strongly inhibits PRMT1, PRMT6, and PRMT8.
- Minimal off-target effects: Little inhibitory effect on PRMT3, PRMT4, and PRMT5.
- Antitumor properties: Exhibits antitumor effects.
- Research use: For research use only.
Medchemexpress LLC 1,3-propanediol, 2-amino-2-(1-nonyl-1H-1,2,3-triazol-4-yl) hydrochloride | 2376132-24-8 | 99.9% | 320.86 | C14H29ClN4O2 | 10 MG
KARI 201 hydrochloride is a dual-action small-molecule research compound that functions as a selective, brain-penetrant acid sphingomyelinase (ASM) inhibitor and a ghrelin receptor (GHSR) agonist. It is intended for preclinical in vitro and in vivo studies and is supplied as a solid for laboratory research use only.
- Selective acid sphingomyelinase inhibitor.
- Ghrelin receptor agonist with brain penetration.
- High purity, 99.9% (HPLC).
- Molecular weight 320.86 g·mol-1.
- Supplied as a 10 mg solid; store sealed at -20°C.
- For research use only; not for human or diagnostic use.
Apexbio Technology LLC Terbinafine 91161-71-6 10mM (in 1mL DMSO)
Terbinafine is an allylamine-class antifungal that exerts fungicidal effects by selectively inhibiting fungal squalene epoxidase thereby disrupting ergosterol biosynthesis and altering fungal cell membrane integrity Research demonstrates Terbinafine s broad-spectrum activity against diverse dermatophytes molds and select dimorphic fungal pathogens with in vitro IC50 values generally ranging from approximately 0 001 to 0 06 g/mL dependent on fungal strain and experimental condition In biological and biomedical studies Terbinafine is frequently employed as a pharmacological tool to probe antifungal mechanisms screen fungal susceptibility profiles and investigate therapeutic strategies against fungal infections
Medchemexpress LLC preQ1 dihydrochlorid 25mg | 86694-45-3 | 252.10 g/mol | C7H11Cl2N5O | 25 MG
preQ1 dihydrochloride is the dihydrochloride salt of pre-queuosine1, a guanine-derived nucleobase and a direct precursor in queuine biosynthesis. It is supplied for research use as a biochemical probe that binds with high affinity to the PreQ1 riboswitch aptamer and is suitable for studies of tRNA modification and riboswitch function.
- High purity suitable for research use (98.88%).
- Solid, white to light brown appearance for easy handling.
- Soluble in DMSO (125 mg/mL) and water (14.29 mg/mL) with sonication or warming.
- Direct precursor in queuine biosynthesis and riboswitch-binding probe.
- Stable when stored sealed away from moisture and light; in solvent -80°C (6 months), -20°C (1 month).