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Apexbio Technology LLC VU 0364439 1246086-78-1 5mg
VU 0364439 (CAS 1246086-78-1) is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4) a member of the class C G protein-coupled receptor (GPCR) family involved in regulating glutamatergic neurotransmission In vitro studies have demonstrated that VU 0364439 enhances mGluR4 activity with an EC50 of 19 8 nM exhibiting greater maximal response and potency compared to the partially selective PAM ()-PHCCC Although its pharmacokinetic properties limit in vivo applications VU 0364439 serves as a valuable tool compound for investigating mGluR4 function and modulation in cellular assays
