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VO-Ohpic trihydrate is a vanadium-containing small-molecule inhibitor of PTEN used in biochemical and cell-based research to probe PI3K/AKT signaling. It reversibly inhibits PTEN with low-nanomolar potency and is supplied as the trihydrate form to aid stability and handling.
Potent PTEN inhibition (IC50 ≈ 46 ± 10 nM).
Vanadium-containing complex for targeted phosphatase interaction.
Suitable for biochemical and cell-based assays probing PI3K/AKT signaling.
Trihydrate form to improve compound stability during storage and handling.
Available in small, research-grade quantities for laboratory use.
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HOE-S 785026 trihydrochloride is a blue fluorescent DNA nuclear stain supplied as a solid. It binds to the minor groove of double-stranded DNA and is used for nuclear staining in fluorescence microscopy and cell-based assays. Available in multiple pack sizes and high purity for research applications.
Blue fluorescent dye suitable for DNA/nuclear staining.
Binds the minor groove of double-stranded DNA for reliable nuclear labeling.
High purity for reproducible experimental results.
Available in small quantities to support assay development and optimization.
Compatible with fluorescence microscopy and cell-based assays.
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Tanuxiciclib trihydrochloride is the trihydrochloride salt of tanuxiciclib, a cyclin-dependent kinase (CDK) inhibitor supplied as a research-grade solid for biochemical and cell-based studies of CDK signaling and cell-cycle regulation. The compound is provided with high chemical purity and is intended for laboratory research applications only.
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Peramivir Trihydrate (CAS 1041434-82-5) is a small-molecule inhibitor targeting influenza viral neuraminidase It is designed to inhibit neuraminidase activity thereby impeding viral particle release and the spread of infection Peramivir Trihydrate exerts its biological activity primarily through competitive inhibition of neuraminidase as a transition-state analog In experimental studies Peramivir Trihydrate demonstrates neuraminidase inhibitory activity with an IC50 of approximately 0 09 nM Based on these pharmacological properties Peramivir Trihydrate holds research potential in investigating influenza virus replication antiviral efficacy and neuraminidase-mediated viral dissemination
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Peramivir Trihydrate (CAS 1041434-82-5) is a small-molecule inhibitor targeting influenza viral neuraminidase It is designed to inhibit neuraminidase activity thereby impeding viral particle release and the spread of infection Peramivir Trihydrate exerts its biological activity primarily through competitive inhibition of neuraminidase as a transition-state analog In experimental studies Peramivir Trihydrate demonstrates neuraminidase inhibitory activity with an IC50 of approximately 0 09 nM Based on these pharmacological properties Peramivir Trihydrate holds research potential in investigating influenza virus replication antiviral efficacy and neuraminidase-mediated viral dissemination
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Irinotecan HCl Trihydrate (CAS 136572-09-3) also known as CPT-11 is a semisynthetic derivative of camptothecin designed to improve therapeutic efficacy while reducing toxicity It acts as a soluble prodrug which undergoes enzymatic cleavage by carboxylesterases in vivo to yield SN-38 a potent inhibitor of topoisomerase I CPT-11 exhibits cytotoxicity against leukemia (P388) cell lines with an IC50 of 3 4 M and demonstrates antitumor activity in vitro and in vivo against both drug-sensitive and multidrug-resistant tumor models It is FDA-approved for treating metastatic colorectal cancer following progression after fluorouracil-based therapies
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VO-Ohpic trihydrate (CAS 476310-60-8) is a highly selective small-molecule inhibitor of the lipid phosphatase PTEN (phosphatase and tensin homolog) with an in vitro IC50 of 35 nM VO-Ohpic shows marked selectivity for PTEN over other phosphatases including CBPs SopB myotubularin SAC1 and PTP- In cell-based assays VO-Ohpic induces dose-dependent phosphorylation of Akt at Ser473 and Thr308 saturating at 75 nM and promotes Akt functional activation as indicated by decreased FoxO3a transcriptional activity In vivo VO-Ohpic administration in MDA PCa-2b tumor xenograft mice results in reduced tumor growth and increased survival This compound serves as a valuable tool for investigating PTEN function and its modulation in insulin signaling glucose uptake and cancer research
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
VO-Ohpic trihydrate (CAS 476310-60-8) is a highly selective small-molecule inhibitor of the lipid phosphatase PTEN (phosphatase and tensin homolog) with an in vitro IC50 of 35 nM VO-Ohpic shows marked selectivity for PTEN over other phosphatases including CBPs SopB myotubularin SAC1 and PTP- In cell-based assays VO-Ohpic induces dose-dependent phosphorylation of Akt at Ser473 and Thr308 saturating at 75 nM and promotes Akt functional activation as indicated by decreased FoxO3a transcriptional activity In vivo VO-Ohpic administration in MDA PCa-2b tumor xenograft mice results in reduced tumor growth and increased survival This compound serves as a valuable tool for investigating PTEN function and its modulation in insulin signaling glucose uptake and cancer research
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More