Organo-Metalloid Compounds
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Filtered Search Results
Medchemexpress LLC Folate-PEG3-C2-acid | 97.6% | C28H36N8O10 | 1 MG
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Folate-PEG3-C2-acid is a specialized acid fragment derived from Folate-PEG3-NHS ester, designed as a PEG-type PROTAC linker. This compound is crucial for the synthesis of PROTAC (PROteolysis TArgeting Chimera) molecules, which are heterobifunctional molecules that induce the degradation of target proteins. Its molecular structure facilitates the creation of complex PROTACs, enabling advanced research in targeted protein degradation.
- PEG-type PROTAC linker
- Acid fragment of Folate-PEG3-NHS ester
- Essential for synthesizing PROTAC molecules
- Purity of 97.56% ensures reliable experimental results
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Medchemexpress LLC N-(Amino-PEG5)-N-bis(PEG4-acid) | 2093152-86-2 | 99.5% | 100 MG
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N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG derivative featuring an amino group and two terminal carboxylic acids. The amino group is reactive with carboxylic acids and activated NHS esters, while the terminal carboxylic acids can react with primary amine groups to form a stable amide bond. This compound is useful in the development of antibody drug conjugates (ADCs).
- Features an amino group and two terminal carboxylic acids.
- Amino group is reactive with carboxylic acids and activated NHS esters.
- Terminal carboxylic acids react with primary amine groups to form a stable amide bond.
- Useful in the development of antibody drug conjugates (ADCs).
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Medchemexpress LLC Pomalidomide 4'-PEG3-azide | 2271036-46-3 | 96.3% | 100 MG
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Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a Pomalidomide-based cereblon ligand and a linker. It is used for the synthesis of iRucaparib-TP3, a highly efficient PARP1 degrader developed using the PROTAC approach. This compound is also a click chemistry reagent containing an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- E3 ligase ligand-linker conjugate
- Incorporates a Pomalidomide-based cereblon ligand
- Utilized for synthesis of iRucaparib-TP3
- Highly efficient PARP1 degrader
- Click chemistry reagent with an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions
- Enables strain-promoted alkyne-azide cycloaddition reactions
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Medchemexpress LLC 2-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethoxy)ethan-1-ol | 1355955-95-1 | MFCD32705069 | 95.0% | 268.78 g/mol | C12H25ClO4 | 250 MG
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HO-PEG3-(CH2)6-Cl is a hydroxy-terminated PEG3 linker bearing a six-carbon chlorinated alkyl chain, used as a building block in PROTAC and bioconjugation chemistry. It serves as a flexible, hydrophilic spacer for attaching ligands, tags, or warheads during linker assembly and small-scale synthesis.
- Polyethylene glycol (PEG3) spacer with terminal hydroxy and six-carbon chloride.
- Designed for PROTAC linker assembly and bioconjugation.
- Flexible and hydrophilic to improve solubility and spacing between functional groups.
- Supplied in research-scale packs suitable for method development and small-scale synthesis.
- Molecular formula C12H25ClO4; molecular weight 268.78 g/mol.
- CAS number 1355955-95-1; supplier-reported purity typically 95%.
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Medchemexpress LLC Mal-amido-PEG3-acid | 2055353-75-6 | 372.37 | 250 MG
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Mal-amido-PEG3-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs, which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only and has not been fully validated for medical applications.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits ubiquitin-proteasome system
- For research use only
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Medchemexpress LLC Mal-amido-PEG3-acid | 2055353-75-6 | 98% | 372.37 | 100 MG
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Mal-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC 0,0'-[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis[hydroxylamine] | 98627-70-4 | 98.0% | C8H20N2O5 | 25 MG
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Bis-aminooxy-PEG3 (HY-140409) is a chemical compound with a molecular formula of C8H20N2O5. It has a CAS number of 98627-70-4 and a purity of 98.0%. This product is stored at 4°C, protected from light. In solvent, it should be stored at -80°C for 6 months or -20°C for 1 month, also protected from light. It is intended for research use only.
- Chemical name: 0,0'-[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis[hydroxylamine]
- Molecular formula: C8H20N2O5
- Purity: 98.0%
- CAS number: 98627-70-4
- Appearance: Colorless to light yellow liquid
- Storage conditions: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light)
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eMolecules 77544-68-4 | Tos-PEG3 | ChemScene | MFCD18433414 | 304.360 | C13H20O6S | 96.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCO | 100mg | 536796555
Tos-PEG3 | ChemScene | 77544-68-4 | MFCD18433414 | 304.360 | C13H20O6S | 96.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCO | 100mg | 536796555
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Medchemexpress LLC Mal-amido-PEG3-acid | 2055353-75-6 | 372.37 | 1G
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Mal-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Pomalidomide-PEG3-C2-NH2 TFA | 2414913-97-4 | 99.0% | 2 G
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Pomalidomide-PEG3-C2-NH2 TFA is a synthetic E3 ligase ligand-linker conjugate, featuring a Pomalidomide-based cereblon ligand and a 3-unit PEG linker. This compound is designed for the synthesis of PROTACs and is intended for research use only.
- Synthetic E3 ligase ligand-linker conjugate
- Features a Pomalidomide-based cereblon ligand and 3-unit PEG linker
- Utilized for the synthesis of PROTACs
- High purity: 99.0%
- Molecular weight: 562.49
- Chemical formula: C23H29F3N4O9
- Appears as a light yellow to yellow solid-liquid mixture
- Soluble in DMSO, ethanol, and water
- Offers multiple dissolution protocols for in vivo studies
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Medchemexpress LLC Acetic acid, 2-(2,4-dichlorophenoxy)-, isooctyl ester | 25168-26-7 | 97.2% | 250 MG
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2,4-D isooctyl ester is a selective herbicide belonging to the chlorophenoxy compound class. It is characterized by a higher boiling point, low volatility, and low drift, making it effective for controlling broadleaf weeds in various settings such as crops, lawns, and forests. This product is for research use only.
- Selective herbicide
- Chlorophenoxy compound
- Higher boiling point, low volatility, and low drift
- Controls broadleaf weeds
- Suitable for use in crops, lawns, and forests
- Purity: 97.17%
- Molecular formula: C16H22Cl2O3
- Molecular weight: 333.25
- Appearance: Colorless to light yellow liquid
- Soluble in DMSO (≥ 175 mg/mL)
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Medchemexpress LLC NH-bis(PEG3-azide) | 1258939-39-7 | 98.0% | C16H33N7O6 | 50 MG
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NH-bis(PEG3-azide) is a PEG-based PROTAC linker used in PROTAC synthesis. It is a click chemistry reagent containing an Azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups or strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups.
- Can be used in the synthesis of PROTACs.
- Contains an azide group, facilitating click chemistry reactions.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Medchemexpress LLC THP-PEG3-OH | 60221-37-6 | 98.7% | 10 G
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THP-PEG3-OH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They consist of two different ligands connected by a linker, with one ligand binding to an E3 ubiquitin ligase and the other to the target protein.
- PEG-based PROTAC linker
- Molecular formula: C11H22O5
- Molecular weight: 234.29
- Appearance: Liquid
- Color: Colorless to light yellow
- For research use only
- Target: PROTAC linkers
- Pathway: PROTAC
- Storage (pure form): -20°C for 3 years; 4°C for 2 years
- Storage (in solvent): -80°C for 6 months; -20°C for 1 month
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Medchemexpress LLC HO-PEG3- CH2 6-Cl
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HO-PEG3-(CH2)6-Cl is a PROTAC linker that can be used to synthesize HaloPROTAC-E (HY-145752)[1]
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Medchemexpress LLC Tos-PEG5-Boc | 581065-94-3 | ≥97.0% | 5 G
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Tos-PEG5-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand and a target protein ligand via a linker. It has a molecular weight of 476.58 and the formula C22H36O9S, appearing as a viscous liquid that is colorless to light yellow.
- PEG-based PROTAC linker
- Used for the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- Viscous liquid, colorless to light yellow appearance
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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