Dimethyl Sulfoxide
Medchemexpress LLC Jsh-23 10Mm 1Ml Dmso Solution | HY-13982-10MM 1ML DMSO
Jsh-23 10Mm 1Ml Dmso Solution
Medchemexpress LLC Pnu-159682 Dmso Recy Reconstit | HY-16700-10MM-DMSO RECONS
Pnu-159682 Dmso Recy Reconstit
Apexbio Technology LLC AST-1306 897383-62-9 10mM (in 1mL DMSO)
AST-1306 (CAS 897383-62-9) is an inhibitor of epidermal growth factor receptor (EGFR) and HER2 receptor tyrosine kinases In biochemical assays AST-1306 inhibits EGFR and HER2 kinase activity with IC50 values of 0 5 nM and 3 nM respectively It also demonstrates inhibitory activity against EGFR mutations such as T790M/L858R reducing receptor phosphorylation and downstream signaling in both cell-free and cellular systems In various animal tumor models including ErbB2-overexpressing and SK-OV-3 xenografts AST-1306 suppresses tumor growth and signaling pathways supporting its use in EGFR- and HER2-related oncology research
Apexbio Technology LLC KPT-185 1333151-73-7 10mM (in 1mL DMSO)
KPT-185 (CAS 1333151-73-7) is an irreversible selective inhibitor of chromosome region maintenance 1 (CRM1) a nuclear export receptor essential for nuclear-cytoplasmic transport KPT-185 binds covalently at Cys528 of CRM1 thereby inhibiting CRM1-mediated nuclear export of tumor suppressor proteins Studies demonstrate that KPT-185 impairs proliferation and colony formation in acute myeloid leukemia (AML) cell lines exhibiting IC50 values ranging from 100 500 nM inducing G1 cell cycle arrest apoptosis and differentiation of AML blasts Additionally KPT-185 reduces growth and promotes apoptosis in pancreatic cancer models (Colo-357 HPAC BxPC-3) highlighting its potential in cancer research
Cayman Chemical PerphenazIn SulfoxIde 10mg
An active metabolite of perphenazine; selectively binds to dopamine D2 and α1-ARs over α2-ARs (Kis= 5.9, 24, and 683 nM, respectively) in rat brain; increases thrombin-induced increases in phosphatidylinositol levels in isolated human platelets at 5 µM
Apexbio Technology LLC Calcifediol 19356-17-3 10mM (in 1mL DMSO)
Calcifediol also termed calcidiol is a hydroxylated vitamin D3 metabolite and the primary circulating form of vitamin D3 in humans Functioning as a prehormone it undergoes further hydroxylation to calcitriol which activates vitamin D receptor (VDR) signaling pathways In vitro assays indicate that calcifediol induces CYP24A1 expression (EC50 70 nM) and thrombomodulin expression at concentrations between 10-100 nM Calcifediol dose-dependently promotes nuclear translocation of VDR at concentrations from 0 1 to 10 M in cultured cells In vivo experiments demonstrated that calcifediol administration influences calcium binding protein expression and calcium transport Clinically calcifediol administration rapidly elevates circulating 25(OH)D3 concentrations facilitating precise modulation of vitamin D status Therefore calcifediol is utilized in biomedical research related to vitamin D metabolism calcium homeostasis and VDR-associated pathways
Apexbio Technology LLC AGI-5198 1355326-35-0 10mM (in 1mL DMSO)
AGI-5198 (CAS 1355326-35-0) is a selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) harboring the R132H substitution Identified via high-throughput screening AGI-5198 blocks mutant IDH1-mediated formation of the oncometabolite R-2-hydroxyglutarate (R-2-HG) in a dose-dependent manner Mechanistically inhibition of mutant IDH1 by AGI-5198 induces expression of differentiation-associated zinc finger and BTB domain-containing protein 16 (ZBTB16 also termed PLZF) decreasing histone H3 lysine 9 trimethylation (H3K9me3) and promoting glioma cell differentiation In experimental glioma models AGI-5198 reduces tumor cell proliferation underscoring its utility for investigating differentiation therapy strategies targeting IDH1-mutant cancers
Medchemexpress LLC Phenol, 2,2'-sulfinylbis[4,6-dichloro- | 844-26-8 | 99.0% | 372.05 | 1 ML
Bithionol sulfoxide is an anti-infection agent for parasites, possessing mutagenic activity. It can be used in the research of parasite infections such as paragonimiasis, flukes, and cestodes infection.
- Acts as an anti-infection agent for parasites.
- Exhibits mutagenic activity.
- Used in research of paragonimiasis, flukes, and cestodes infection.
- Shows toxicity to Neoparamoeba spp parasites in seawater.
- Effective against natural rumen fluke infections in dairy cattle.
Apexbio Technology LLC Alfacalcidol 41294-56-8 10mM (in 1mL DMSO)
Alfacalcidol is a vitamin D analog functioning as an inhibitor of bone resorption through modulation of calcium homeostasis By binding specifically to vitamin D receptors (VDR) located in calcium-regulating tissues such as intestine bone kidney and parathyroid glands Alfacalcidol contributes to mineral metabolism and bone turnover regulation Preclinical studies using ovariectomized animal models demonstrate that Alfacalcidol at pharmacological doses not inducing hypercalcemia suppresses osteoclast-mediated bone resorption while preserving calcium balance in plasma and urine Due to these properties Alfacalcidol is frequently utilized in biomedical research to investigate mechanisms involved in osteoporosis progression and potential therapeutic interventions addressing calcium and bone metabolism disorders
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology, 67-68-5, MFCD00002089, 100mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, for molecular biology, Synonym: DMSO
Apexbio Technology LLC STF-62247 315702-99-9 10mM (in 1mL DMSO)
STF-62247 (CAS 315702-99-9) is a small molecule that selectively targets renal cell carcinoma (RCC) cells carrying von Hippel-Lindau (VHL) gene deletions It exhibits cytotoxicity in both wild-type and VHL-deficient RCC cells via a mechanism independent of hypoxia-inducible factor (HIF) with reported IC50 values of 16 M and 0 625 M respectively In VHL-deficient RCC cells STF-62247 induces acidification autophagy and subsequent apoptotic cell death In mouse xenograft models bearing VHL-deficient SN12C tumors STF-62247 significantly reduced tumor growth This compound is useful for studying therapeutic strategies targeting VHL-deficient tumors
Apexbio Technology LLC Sodium Picosulfate 10040-45-6 10mM (in 1mL DMSO)
Sodium picosulfate is an organic stimulant laxative widely utilized to investigate bowel motility and electrolyte balance Its pharmacological activity involves inhibition of fluid and electrolyte absorption alongside enhancement of their secretion in the intestinal lumen thus promoting bowel evacuation In vitro studies evaluating human rat and rabbit liver cell cultures showed sodium picosulfate interaction with hepatic cells notably rabbit hepatocytes demonstrated higher sensitivity reflected by decreased cellular protein content at concentrations in the g/ml range Clinical research supports the utility of sodium picosulfate in experimental constipation models including drug-induced and chronic constipation settings allowing assessment of bowel function and symptoms such as abdominal distension and stool consistency
Supelco Inc Dimethyl Sulfoxide Biotech, 50 Milliliter
Dimethyl sulfoxide; 50mL; M.W. 78.13; (CH3)2SO; B.P. 189 deg.C(lit.); M.P. 16 deg. to 19 deg.C(lit.); CAS: 67-68-5
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology | 67-68-5 | MFCD00002089 | 50ml
Dimethyl sulfoxide for molecular biology | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 50ml