Dimethyl Sulfoxide
Apexbio Technology LLC SRT1720 HCl 1001645-58-4 10mM (in 1mL DMSO)
SRT1720 HCl is a small molecule activator of SIRT1 exerting more potent activation than resveratrol It functions through a SIRT1- and PGC-1 -dependent mechanism modulating mitochondrial oxidative metabolism and insulin sensitivity The compound has demonstrated activity in regulating cell growth and apoptosis in multiple myeloma (MM) cells without notably affecting normal cell viability Its antitumor properties relate to activation of caspase-8 caspase-9 caspase-3 and PARP enhancement of reactive oxygen species generation induction of ATM/CHK2 signaling suppression of NF- B signaling and reduction of VEGF-induced migration SRT1720 is utilized in biomedical research to investigate metabolic pathways tumor biology and potential sensitization effects to chemotherapy agents
Apexbio Technology LLC Reserpine 50-55-5 10mM (in 1mL DMSO)
Reserpine a naturally derived alkaloid isolated from plants of the genus Rauvolfia functions primarily through the inhibition of vesicular monoamine transporter 2 (VMAT2) By blocking VMAT2-mediated uptake reserpine causes depletion of monoamine neurotransmitters such as dopamine norepinephrine and serotonin from synaptic storage vesicles In biochemical assays reserpine inhibits VMAT2 activity with an IC50 value typically ranging from 30-50 nM depending on assay specifics In biomedical and pharmacological research this compound is commonly utilized to model neurotransmitter depletion mechanisms in vitro and in animal models facilitating studies on monoamine-related neurological disorders neurotransmission pathways as well as serotonergic dopaminergic and adrenergic signaling
Apexbio Technology LLC AST-1306 897383-62-9 10mM (in 1mL DMSO)
AST-1306 (CAS 897383-62-9) is an inhibitor of epidermal growth factor receptor (EGFR) and HER2 receptor tyrosine kinases In biochemical assays AST-1306 inhibits EGFR and HER2 kinase activity with IC50 values of 0 5 nM and 3 nM respectively It also demonstrates inhibitory activity against EGFR mutations such as T790M/L858R reducing receptor phosphorylation and downstream signaling in both cell-free and cellular systems In various animal tumor models including ErbB2-overexpressing and SK-OV-3 xenografts AST-1306 suppresses tumor growth and signaling pathways supporting its use in EGFR- and HER2-related oncology research
Apexbio Technology LLC (-)-MK 801 121917-57-5 10mM (in 1mL DMSO)
(-)-MK 801 (CAS 121917-57-5) is a small molecule serving as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor It crosses the blood-brain barrier binding reversibly and with high affinity to cortical membranes in a saturable regionally specific manner notably within the hippocampus (-)-MK 801 selectively inhibits depolarization responses to NMDA receptor activation leading to suppression of seizure-like neuronal activity induced by neurotoxins such as tetrodotoxin Due to these properties it has widespread use as a research tool in neuroscience particularly in investigating excitotoxicity epilepsy and neurological disorders associated with NMDA receptor dysfunction
Apexbio Technology LLC Sodium Picosulfate 10040-45-6 10mM (in 1mL DMSO)
Sodium picosulfate is an organic stimulant laxative widely utilized to investigate bowel motility and electrolyte balance Its pharmacological activity involves inhibition of fluid and electrolyte absorption alongside enhancement of their secretion in the intestinal lumen thus promoting bowel evacuation In vitro studies evaluating human rat and rabbit liver cell cultures showed sodium picosulfate interaction with hepatic cells notably rabbit hepatocytes demonstrated higher sensitivity reflected by decreased cellular protein content at concentrations in the g/ml range Clinical research supports the utility of sodium picosulfate in experimental constipation models including drug-induced and chronic constipation settings allowing assessment of bowel function and symptoms such as abdominal distension and stool consistency
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitable for HPLC, >=99.7% | 67-68-5 | MFCD00002089 | 12X100ML
Dimethyl sulfoxide suitable for HPLC, >=99.7% | Purity: >=99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 12X100ML
Apexbio Technology LLC Thioridazine HCl 130-61-0 10mM (in 1mL DMSO)
Thioridazine HCl is a pharmacological inhibitor targeting dopamine receptor subtypes D2 and D4 as well as a calcium channel blocker It modulates dopaminergic neurotransmission by interfering with receptor-mediated signaling and reduces intracellular calcium influx via calcium channel inhibition (IC50 approximately 1 0 M) Thioridazine is frequently utilized in research contexts involving dopaminergic signaling pathways calcium-related cellular processes and investigations of pharmacological sensitivity shifts following prolonged receptor modulation Specifically it is employed experimentally to examine receptor-mediated cardiovascular responses such as hypotension and to assess alterations in dopamine receptor responsiveness induced by chronic exposure regimens
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ReagentPlus(R), >=99.5% | 67-68-5 | MFCD00002089 | 4L
Dimethyl sulfoxide ReagentPlus(R), >=99.5% | Purity: >=99.5% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 4L
Apexbio Technology LLC Tolcapone 134308-13-7 10mM (in 1mL DMSO)
Tolcapone (CAS 134308-13-7) is an orally bioavailable reversible small-molecule inhibitor targeting catechol-O-methyltransferase (COMT) Acting through competitive inhibition tolcapone structurally incorporates a catechol moiety with electron-withdrawing substituents facilitating anionic formation that binds potently to COMT s catalytic site (reported IC50 of approximately 36 nM in rat liver assays) By competitively occupying this active site tolcapone prevents the enzymatic methylation of endogenous catechols such as levodopa thus prolonging levodopa s bioavailability Tolcapone is primarily investigated as adjunctive therapeutic agent in Parkinson s disease research enabling reduced levodopa dosage while enhancing symptomatic control
Apexbio Technology LLC Roflumilast 162401-32-3 10mM (in 1mL DMSO)
Roflumilast is an orally available selective inhibitor of phosphodiesterase-4 (PDE-4) with an IC50 value of approximately 0 11 nM PDE-4 enzymes catalyze the hydrolysis of cyclic adenosine monophosphate (cAMP) and are predominantly expressed in various inflammatory and immune cells By selectively inhibiting PDE-4 activity Roflumilast elevates intracellular cAMP levels thus regulating cellular inflammatory signaling pathways This mechanism supports its use in the reduction of inflammatory responses associated with chronic obstructive pulmonary disease (COPD) Additionally Roflumilast has been investigated experimentally regarding its potential influence on glucose metabolism in early-stage type 2 diabetes mellitus
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology | 67-68-5 | MFCD00002089 | 1L
Dimethyl sulfoxide for molecular biology | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 1L