Dimethyl Sulfoxide
Apexbio Technology LLC PTC124 (Ataluren) 775304-57-9 10mM (in 1mL DMSO)
PTC124 (Ataluren CAS 775304-57-9) is a small molecule modulator that selectively targets premature termination codons (nonsense mutations) which are point mutations causing early termination during translation By promoting ribosomal read-through of these mutations PTC124 enhances the synthesis of full-length functional proteins In vitro studies demonstrated its activity at IC50 of approximately 0 1 M Research in MDX mouse skeletal muscle cells and human induced pluripotent stem cell-derived retinal pigment epithelium cells confirmed its capacity to restore protein production Animal models of Duchenne muscular dystrophy and cystic fibrosis exhibited improved muscle and channel protein function upon oral or subcutaneous administration suggesting its potential for addressing genetic diseases associated with nonsense mutations
Apexbio Technology LLC Ciprofibrate 52214-84-3 10mM (in 1mL DMSO)
Ciprofibrate is a selective agonist targeting peroxisome proliferator-activated receptor alpha (PPAR ) a nuclear receptor involved in regulating lipid metabolism and energy homeostasis Its activation promotes gene expression linked to fatty acid oxidation triglyceride reduction and cholesterol metabolism Ciprofibrate is frequently applied as a molecular tool in biomedical research to investigate mechanisms underlying dyslipidemia atherosclerosis and metabolic-related disorders Additionally due to its receptor-specific mode of action it serves as a standard experimental reference in in vitro assays and animal models assessing lipid-lowering therapeutic strategies and PPAR -dependent signaling pathways
Apexbio Technology LLC Entinostat (MS-275,SNDX-275) 209783-80-2 10mM (in 1mL DMSO)
Entinostat (MS-275 SNDX-275 CAS 209783-80-2) is an orally bioavailable small molecule inhibitor targeting histone deacetylases (HDACs) a family of enzymes involved in transcriptional regulation by modifying histone acetylation Specifically entinostat exhibits inhibitory activity against class I HDAC enzymes HDAC1 HDAC3 and HDAC8 with reported IC50 values of 0 368 M 0 501 M and 63 4 M respectively In preclinical investigations entinostat demonstrates anti-proliferative effects in diverse human tumor cell lines including breast colon lung multiple myeloma ovarian pancreatic prostate cancers and leukemia Due to these properties entinostat is widely utilized in oncology research
Apexbio Technology LLC PF-8380 1144035-53-9 10mM (in 1mL DMSO)
PF-8380 (CAS 1144035-53-9) is a selective inhibitor of autotaxin (ATX) a secreted enzyme with lysophospholipase D activity that converts lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) As increased local LPA production promotes tumor proliferation and invasion targeting ATX reduces LPA synthesis PF-8380 demonstrates potent ATX inhibition (IC50 2 8 nM) significantly lowering LPA in plasma and tissue in rodent models It reduces Akt activation enhances radiosensitivity and diminishes growth and invasion of glioblastoma cells indicating utility in oncology research focused on ATX-LPA signaling pathways
Apexbio Technology LLC Olmesartan 144689-24-7 10mM (in 1mL DMSO)
Olmesartan (CAS 144689-24-7) is a small molecule angiotensin II receptor antagonist primarily acting by selectively blocking the binding of angiotensin II to AT1 receptors This mechanism interrupts angiotensin II-mediated vasoconstriction and aldosterone secretion resulting in antihypertensive effects In biomedical research Olmesartan serves as a valuable tool for examining hypertensive disease models elucidating angiotensin II signaling pathways and exploring therapeutic strategies targeting cardiovascular regulation
Apexbio Technology LLC Caspofungin(Synonyms: Cancidas, Caspofungin acetate, MK-0991, L-743872), 10mM (in 1mL DMSO), CAS: 162808-62-0.
Caspofungin (CAS 162808-62-0) is a small-molecule inhibitor of -1 3-glucan synthase an enzyme essential for the biosynthesis of -(1 3)-D-glucan a fundamental cell wall component in pathogenic fungi such as Candida albicans Caspofungin selectively inhibits -1 3-glucan synthase activity with a reported IC50 of approximately 0 6 nmol/L in membrane preparations of C albicans Caspofungin demonstrates potent antifungal activity against various Candida isolates including azole-resistant strains (MIC90 0 5 g/mL) and shows prolonged post-antifungal effects lasting 6 8 hours It is widely utilized in biomedical research involving fungal infections and antifungal therapeutics
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 200L
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 200L
Crescent Chemical Co Inc DIMETHYL SULFOXIDE
Dimethyl sulfoxide research grade Highly active solvent and pharmaceutical vehicle; for freezing cells. For gradient centrifugation (1). Determination of cysteine and cystine in proteins (2). Size - 250ML Storage Conditions - +15 °C TO +30 °C Catalog
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide United States Pharmacopeia (USP) Reference Standard | 67-68-5 | MFCD00002089 | 3G
Dimethyl sulfoxide United States Pharmacopeia (USP) Reference Standard | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 3G
Apexbio Technology LLC N6-methyladenosine (m6A) 1867-73-8 10mM (in 1mL DMSO)
N6-methyladenosine (m6A) is a purine derivative functioning primarily as an adenosine receptor agonist and modulates adenylate cyclase activity with reported ED50 approximately 17 25 M It is a common internal modification in eukaryotic messenger RNAs predominantly occurring within consensus motif RRACH (R G or A H A C or U) and affecting RNA stability processing and translation Experimental studies indicate m6A application in cellular models such as murine erythroleukemia (MEL) cells reduces -globin mRNA accumulation thereby suppressing erythroid differentiation initiation Due to its epigenetic regulatory role m6A serves as a tool for studying RNA methylation-dependent gene expression and cellular differentiation