Dimethyl Sulfoxide
Apexbio Technology LLC Valganciclovir HCl 175865-59-5 10mM (in 1mL DMSO)
Valganciclovir hydrochloride is an antiviral prodrug that undergoes rapid enzymatic conversion to the active metabolite ganciclovir after oral administration Ganciclovir inhibits viral replication by selectively targeting viral DNA polymerase thereby interfering with viral DNA synthesis and slowing cytomegalovirus (CMV) proliferation Valganciclovir is commonly utilized in laboratory studies to evaluate antiviral activity against CMV and related herpesviruses and to investigate its therapeutic potential in CMV-associated infections including retinitis and organ transplant-associated CMV infections In vitro studies report an IC50 value for valganciclovir-derived ganciclovir ranging approximately from 0 2 to 2 8 M depending on experimental cell type and viral strain
Apexbio Technology LLC Latrepirdine 97657-92-6 10mM (in 1mL DMSO)
Latrepirdine (CAS 97657-92-6) is an orally bioavailable small molecule investigated for its neuroprotective properties in preclinical studies of neurodegenerative diseases including Alzheimer s and Huntington s diseases Although its precise mechanism remains under investigation latrepirdine has demonstrated the ability to inhibit neuronal cell death pathways in animal disease models Moreover preliminary evidence indicates potential cognitive enhancement in normal physiological conditions Latrepirdine serves as a relevant tool compound to study neuronal survival mechanisms and cognitive function regulation
Apexbio Technology LLC GYY 4137 morpholine salt(Synonyms: GYY4137, Morpholin-4-ium 4-methoxyphenyl(morpholino)phosphinodithioate, GYY-4137), 10mM (in 1mL DMSO), CAS: 106740-09-4.
GYY 4137 morpholine salt (CAS 106740-09-4) is a slow-releasing hydrogen sulfide (H S) donor that exerts biological activity by modulating signaling pathways involved in vasodilation and blood pressure regulation In experimental studies this compound demonstrates the capacity to suppress cellular proliferation induce apoptosis and arrest cell cycle progression Due to these properties GYY 4137 morpholine salt is widely utilized in research investigating hypertension inflammation and cancer biology
Apexbio Technology LLC Ro3280 1062243-51-9 10mM (in 1mL DMSO)
Ro3280 (CAS 1062243-51-9) is a selective small-molecule inhibitor targeting Polo-like kinase 1 (PLK1) exerting inhibitory activity with an IC50 of 3 nM PLK1 is a cell cycle kinase involved prominently in regulating progression from G2 to M phase frequently overexpressed in various malignancies Ro3280 inhibits PLK1 activity and induces apoptosis and cell cycle disruption in acute leukemia cell lines (e g U937 HL-60 NB4 K562 MV4-11) and diverse solid tumor models (e g lung carcinoma H82 colon carcinoma HT-29 breast carcinoma MDA-MB-468) In mouse xenografts of HT-29 tumors Ro3280 demonstrates significant tumor regression highlighting its potential in cancer therapeutics research
Apexbio Technology LLC SB 225002 182498-32-4 10mM (in 1mL DMSO)
SB 225002 (CAS 182498-32-4) is a selective non-peptide antagonist targeting the chemokine receptor CXCR2 a G protein-coupled receptor involved in interleukin-8 (IL-8)-mediated neutrophil chemotaxis and polarization It inhibits IL-8 binding to CXCR2 with an IC50 of 22 nM and displays over 150-fold selectivity against CXCR1 SB 225002 suppresses neutrophil migration and polarization triggered by IL-8 and GRO in cell-based assays and animal models It also promotes apoptosis and mitotic catastrophe in ovarian cancer cells independently of p53 status highlighting its utility in inflammation and oncology research
Apexbio Technology LLC AM966 1228690-19-4 10mM (in 1mL DMSO)
AM966 (CAS 1228690-19-4) is an orally bioavailable small-molecule antagonist that selectively targets Lysophosphatidic acid type 1 receptor (LPA1) AM966 exhibits potent inhibitory activity against LPA1 receptors from humans and mice with IC50 values of approximately 17 nM and 19 nM respectively demonstrating selectivity over other LPA receptor subtypes (LPA2 5) In vitro AM966 blocks LPA-mediated chemotactic responses in IMR-90 human lung fibroblasts A2058 human melanoma cells and CHO cell lines In vivo AM966 effectively attenuates lung fibrosis inflammation and associated weight loss in bleomycin-induced murine pulmonary fibrosis models highlighting its utility in research on fibrotic diseases
Apexbio Technology LLC GDC-0449 (Vismodegib) 879085-55-9 10mM (in 1mL DMSO)
GDC-0449 (Vismodegib CAS 879085-55-9) is a small molecule that selectively inhibits the Hedgehog (Hh) signaling pathway by binding to the Smoothened (SMO) receptor thus preventing downstream activation of Hh target genes implicated in cellular proliferation and differentiation This compound emerged from screening small-molecule libraries followed by medicinal chemistry optimization Preclinical evaluation demonstrated antitumor activity in murine models of medulloblastoma and xenograft models derived from human colon and pancreatic cancers Currently GDC-0449 is under investigation for locally advanced and metastatic solid tumors
Apexbio Technology LLC Quizartinib (AC220) 950769-58-1 10mM (in 1mL DMSO)
Quizartinib (AC220) is a second-generation small molecule inhibitor specifically targeting FMS-like tyrosine kinase 3 (FLT3) It exhibits potent inhibitory activity against FLT3 kinases harboring internal tandem duplication (ITD) and wild-type forms with reported IC50 values around 1 1 nM and 4 2 nM respectively Quizartinib demonstrates selectivity for FLT3 with minimal inhibition toward other kinases such as KIT PDGFR / RET and CSF-1R In cell-based assays using MV4-11 AML cell lines that express FLT3-ITD quizartinib reduces FLT3 phosphorylation thus inhibiting downstream signaling pathways involved in tumor cell proliferation and survival Quizartinib is utilized primarily in leukemia research to examine FLT3 signaling dependency and resistance mechanisms providing a useful tool for investigating molecular pathways and therapeutic strategies in acute myeloid leukemia (AML)
Apexbio Technology LLC WAY-600 1062159-35-6 10mM (in 1mL DMSO)
WAY-600 is an ATP-competitive inhibitor targeting mammalian target of rapamycin (mTOR) specifically inhibiting the phosphorylation activity mediated by mTOR complexes It suppresses mTORC1 signaling via inhibition of phosphorylation of ribosomal S6 kinase (S6K) at Thr389 and attenuates mTORC2 signaling by inhibiting phosphorylation of protein kinase B (AKT) at Ser473 Importantly WAY-600 does not interfere with AKT phosphorylation at Thr308 The compound demonstrates marked selectivity for mTOR over phosphatidylinositol 3-kinase (PI3K) isoforms displaying greater than 100-fold selectivity against PI3K and over 500-fold selectivity against PI3K WAY-600 represents a valuable tool for investigating mTOR-dependent signaling pathways metabolism regulation cellular proliferation autophagy and related oncological and metabolic research areas
Apexbio Technology LLC Tipifarnib (Zarnestra) 192185-72-1 10mM (in 1mL DMSO)
Tipifarnib (Zarnestra CAS 192185-72-1) is an orally bioavailable imidazole quinolinone derivative specifically designed as a non-peptidomimetic inhibitor of the enzyme farnesyltransferase (FTase) FTase catalyzes the farnesylation of proteins essential for tumor cell proliferation and survival By selectively blocking FTase activity Tipifarnib disrupts downstream signaling pathways suppressing cellular proliferation and inducing apoptosis across diverse cancer cell types notably acute myeloid leukemia (AML) and multiple myeloma (MM) In preclinical models Tipifarnib demonstrates antiproliferative and pro-apoptotic activities supporting its utility in targeted cancer therapy research
Apexbio Technology LLC E-64 66701-25-5 10mM (in 1mL DMSO)
E-64 is a selective inhibitor targeting cysteine proteases isolated originally from Aspergillus cultures Structurally classified as an L-trans-epoxysuccinyl peptide it irreversibly inhibits proteases such as papain ficin and bromelain by covalent binding to the active-site cysteine residue Its inhibitory activity additionally extends to mammalian cysteine proteases including cathepsins B H and L as well as calcium-dependent protease calpain with reported IC50 values ranging approximately between 10-100 nM depending on specific enzyme assays and conditions In research laboratories E-64 is primarily utilized for mechanistic studies active-site titration assays and quantitative evaluation of cysteine protease concentrations and enzyme kinetics
Medchemexpress LLC Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML
Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML