Dimethyl Sulfoxide
Apexbio Technology LLC Dopamine HCl 62-31-7 10mM (in 1mL DMSO)
Dopamine HCl (CAS 62-31-7) is a catecholamine neurotransmitter that functions as an endogenous agonist at dopamine receptors (subtypes D1 D5) Mechanistically dopamine activates these G protein-coupled receptors modulating neurotransmission and influencing diverse physiological processes such as motor control cognition motivation and neuroendocrine regulation In biomedical research dopamine HCl serves as a standard reagent for investigating dopaminergic signaling pathways receptor pharmacology and the molecular basis of neurological disorders
Medchemexpress LLC Carbocysteine sulfoxide | 5439-87-2 | MFCD21364079 | 99.0% | 195.19 g/mol | C5H9NO5S | 10 MG
Carbocysteine sulfoxide is a small-molecule impurity of carbocisteine intended for research use. The substance is identified by CAS number 5439-87-2, has the molecular formula C5H9NO5S, and a molecular weight of 195.19 g/mol. It is provided in small-mass packages for laboratory and analytical applications.
- Used as an impurity reference for analytical method development.
- Supplied in small-mass packages suitable for laboratory research.
- Identified by CAS number 5439-87-2 for substance tracking.
- Molecular formula C5H9NO5S and molecular weight 195.19 g/mol.
- Intended for research use only; not for human or clinical use.
Apexbio Technology LLC Trichostatin A (TSA) 58880-19-6 10mM (in 1mL DMSO)
Trichostatin A (TSA CAS 58880-19-6) is a histone deacetylase (HDAC) inhibitor and antifungal antibiotic isolated from microbial sources TSA acts by reversibly inhibiting HDAC enzymes in a noncompetitive manner leading to increased acetylation of histones particularly histone H4 In mammalian cell cultures TSA treatment results in G1 and G2 phase arrest induction of differentiation and reversion of transformed cellular phenotypes In human breast cancer cell lines TSA inhibits proliferation (IC50 124 4 120 4 nM) and induces hyperacetylation of histone proteins highlighting its utility as a tool compound for investigating epigenetic regulation and oncology-related mechanisms
Apexbio Technology LLC RG 108 48208-26-0 10mM (in 1mL DMSO)
RG 108 (CAS 48208-26-0) is a small-molecule inhibitor of DNA methyltransferases (DNMTs) It acts by directly blocking DNMT activity without forming covalent enzyme-adducts leading to DNA demethylation and consequent reactivation of epigenetically silenced tumor suppressor genes However RG 108 treatment does not affect methylation status of centromeric satellite DNA sequences In cellular models RG 108 promotes reprogramming efficiency especially enhancing induction of pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs) It is useful for studying epigenetic gene regulation tumor suppression pathways and cellular reprogramming mechanisms
Apexbio Technology LLC MLN120B 783348-36-7 10mM (in 1mL DMSO)
MLN120B (CAS 783348-36-7) is a small molecule inhibitor targeting the beta subunit of I B kinase (IKK ) an enzyme integral to the NF- B signaling pathway IKK mediates phosphorylation and subsequent degradation of the NF- B inhibitor I B thereby activating NF- B-dependent transcription involved in inflammatory and immune responses MLN120B inhibits IKK -catalyzed phosphorylation of I B (IC50 20 M) attenuating NF- B activation in multiple myeloma cell lines (RPMI 8226 INA 6 MM 1S) and reducing inflammation-induced joint damage in animal arthritis models Consequently MLN120B serves as a research tool in studying NF- B signaling-mediated disorders
Apexbio Technology LLC Stattic 19983-44-9 10mM (in 1mL DMSO)
Stattic (CAS 19983-44-9) is a small-molecule inhibitor specifically targeting signal transducer and activator of transcription 3 (STAT3) It suppresses STAT3 activation by blocking its dimerization nuclear translocation and subsequent transcriptional activity In vitro studies demonstrate Stattic inhibits proliferation in multiple head and neck squamous cell carcinoma (HNSCC) cell lines including UM-SCC-17B OSC-19 Cal33 and UM-SCC-22B with reported IC50 values ranging from approximately 2 3 to 3 5 M Additionally Stattic downregulates STAT3-mediated hypoxia-inducible factor-1 (HIF-1) expression resulting in enhanced radiosensitivity in HNSCC cells and shows activity in mouse xenograft tumor models Therefore Stattic serves as a research tool for investigating STAT3-associated signaling pathways and cancer biology
Apexbio Technology LLC BIX 02565 1311367-27-7 10mM (in 1mL DMSO)
BIX 02565 (CAS 1311367-27-7) is a potent inhibitor of ribosomal S6 kinase 2 (RSK2) showing an IC50 of approximately 1 nM RSK activation typically stimulates Na /H exchanger (NHE) crucial for early cellular stress responses involving intracellular pH regulation calcium handling and potential induction of cardiac hypertrophy BIX 02565 also inhibits adrenergic ( 1A 1B 1D 2A 2) imidazoline I2 LRRK2 and PKD1 receptors at varying potencies (IC50 0 052 1 820 M 16 nM and 35 nM respectively) In vivo studies in rats demonstrated dose-dependent decreases in heart rate and mean arterial pressure This compound aids research into signaling pathways relevant to cardiovascular disorders and kinase biology
Apexbio Technology LLC Crenolanib (CP-868596)(Synonyms: CP-868596, Crenolanib besylate, AR-868596, PDGFR inhibitor CP-868596, PDGFR-beta inhibitor CP-868596), 10mM (in 1mL DMSO), CAS: 670220-88-9.
Crenolanib (CP-868596 CAS 670220-88-9) is a selective inhibitor targeting receptor tyrosine kinases PDGFR PDGFR and FLT3 exhibiting Kd values of 3 2 nM 2 1 nM and 0 74 nM respectively It notably suppresses the FLT3 autophosphorylation and proliferation mediated via PDGFR mutations that confer resistance to imatinib such as D842V (IC50 10 nM) but does not inhibit the V561D mutant Additionally crenolanib reduces kinase activity of the FIP1L1-PDGFRA fusion protein (IC50 1 nM) and proliferation in EOL-1 cells It serves as a research tool for kinase-driven malignancies particularly those resistant to other kinase inhibitors
Apexbio Technology LLC Tenofovir Disoproxil Fumarate 202138-50-9 10mM (in 1mL DMSO)
Tenofovir disoproxil fumarate is an antiviral nucleotide analog functioning as a nucleoside reverse transcriptase inhibitor (NRTI) Upon cellular uptake it undergoes enzymatic hydrolysis to form the active metabolite tenofovir subsequently phosphorylated to the diphosphate derivative This phosphorylated metabolite competitively inhibits HIV-1 reverse transcriptase and induces DNA chain termination In vitro studies using MT-2 cells and peripheral blood mononuclear cells (PBMC) have demonstrated suppression of HIV replication with reported EC50 values approximately 0 007 mol/L and 0 005 mol/L respectively This compound is routinely utilized in research investigating HIV replication mechanisms antiretroviral therapies and drug resistance profiles
Medchemexpress LLC Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML
Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML
Apexbio Technology LLC VS-5584 (SB2343) 1246560-33-7 10mM (in 1mL DMSO)
VS-5584 (SB2343 CAS 1246560-33-7) is a purine-based inhibitor targeting the mammalian target of rapamycin (mTOR) and all class I phosphoinositide 3-kinase (PI3K) isoforms (PI3K PI3K PI3K and PI3K ) It functions through ATP-competitive inhibition displaying IC50 values of 37 16 68 25 and 42 nmol/L against mTOR PI3K PI3K PI3K and PI3K respectively Through inhibition of PI3K and mTORC1/2-mediated substrate phosphorylation VS-5584 modulates the PI3K/mTOR signaling pathway frequently dysregulated in cancers In preclinical tumor xenograft studies VS-5584 has demonstrated dose-dependent inhibition of tumor growth and pathway signaling underscoring its utility in oncology research
Apexbio Technology LLC TAK-242 243984-11-4 10mM (in 1mL DMSO)
TAK-242 (CAS 243984-11-4) also known as resatorvid is a cyclohexene derivative that functions as a selective inhibitor of Toll-like receptor 4 (TLR4) signaling Mechanistically TAK-242 binds specifically to the intracellular domain of TLR4 disrupting its interaction with downstream adaptor proteins and thus suppressing activation of inflammatory signal pathways triggered by lipopolysaccharide (LPS) In vitro TAK-242 inhibits LPS-induced production of nitric oxide TNF- and interleukin-6 in macrophages (IC50 1 1 11 nM) Preclinical animal models indicate its potential usefulness in mitigating inflammatory responses associated with neuropsychiatric conditions triggered by stress
Apexbio Technology LLC LDC000067 1073485-20-7 10mM (in 1mL DMSO)
LDC000067 (CAS 1073485-20-7) also known as LDC067 is a selective inhibitor of cyclin-dependent kinase 9 (CDK9) CDK9 partners with cyclin T to form positive transcription elongation factor b (P-TEFb) which regulates RNA polymerase II by phosphorylating its C-terminal domain thus controlling gene transcription elongation LDC000067 inhibits CDK9 activity with an IC50 of approximately 44 10 nM Compared to other CDKs LDC000067 demonstrates notable selectivity showing 55-fold higher specificity against CDK2 and over 230-fold greater selectivity relative to CDK6 and CDK7 By selectively blocking CDK9 this ATP-competitive inhibitor reduces cellular transcription of short-lived mRNAs associated with proliferation and apoptosis such as MYC and MCL1 Thus LDC000067 is applicable in transcription regulation and cancer-related pathway studies