Tetrahydrofuran
Medchemexpress LLC N-(5-(((4-Me-1,2,5-thiadiazol-3-yl)thio)methyl)-1,3,4-thiadiazol-2-yl)-4-(4-(CF3)Ph)thiazol-2-amine | 2809469-05-2 | 99.0% | 501.56 g·mol⁻¹ | C21H18F3NO4S3 | 100 MG
NAZ2329 is a research-grade, cell-permeable small-molecule inhibitor that allosterically and preferentially targets the receptor-type protein tyrosine phosphatases PTPRZ and PTPRG. It has demonstrated inhibition of glioblastoma cell growth and suppression of stem cell-like properties in published studies. Supplied as a purified powder for laboratory research use.
- Allosteric inhibitor of PTPRZ and PTPRG.
- Demonstrated antiproliferative activity in glioblastoma models.
- High reported purity (99.02%).
- Soluble in DMSO (100 mg/mL); in vivo formulation protocols available.
- Recommended storage: powder at -20 °C for long-term stability.
![Medchemexpress LLC N-[(E)-[4-(diethylamino)-2-hydroxyphenyl]methylideneamino]pyridine-4-carboxamide | 140405-36-3 | MFCD00542031 | 99.7% | 312.37 g/mol | C17H20N4O2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245949.png-250.jpg)
Medchemexpress LLC N-[(E)-[4-(diethylamino)-2-hydroxyphenyl]methylideneamino]pyridine-4-carboxamide | 140405-36-3 | MFCD00542031 | 99.7% | 312.37 g/mol | C17H20N4O2 | 50 MG
RSVA405 is a small-molecule research compound that potently activates AMP-activated protein kinase (AMPK) and is orally active in vivo. It facilitates CaMKKβ-dependent AMPK activation (EC50 = 1 μM), inhibits mTOR signaling, promotes autophagy and amyloid-β (Aβ) degradation, and shows anti-inflammatory activity via STAT3 inhibition.
- Potent AMPK activator (EC50 = 1 μM).
- Orally active small-molecule research compound.
- Promotes autophagy and increases Aβ degradation.
- Inhibits mTOR signaling and STAT3-mediated inflammation.
- High purity (≈99.7%) light yellow solid.
- Recommended storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g/mol | C25H20F3N5O2 | 50 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony stimulating factor 1 receptor (CSF1R) with a reported IC50 of 0.5 nM. It shows good intestinal permeability in Caco-2 assays and favorable oral pharmacokinetics in mice. The compound is supplied as a solid for research use and includes standard storage recommendations and available solution formulations.
- Potent CSF1R inhibition (IC50 0.5 nM).
- Molecular formula C25H20F3N5O2; molecular weight 479.45 g/mol.
- High purity (98.04%).
- White to off-white solid physical form.
- Stable storage: powder -20°C for up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Available in multiple sizes and as a 10 mM solution in DMSO.
![Medchemexpress LLC Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate | 173436-66-3 | 99.8% | 100MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232744.png-250.jpg)
Medchemexpress LLC Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate | 173436-66-3 | 99.8% | 100MG
Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate | 173436-66-3 | 99.8% | 100MG
Medchemexpress LLC BDP9066 | 2226507-04-4 | 98.18% | 348.44 | 50 MG
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase (MRCK) inhibitor. It inhibits MRCKβ with an IC50 of 64 nM in SCC12 cells and has Ki values of 0.0136 nM for MRCKα and 0.0233 nM for MRCKβ. This compound demonstrates a therapeutic effect on skin cancer by reducing substrate phosphorylation.
- Potent and selective inhibitor of MRCKα and MRCKβ.
- Exhibits antiproliferative effects, particularly in hematologic cancer cells.
- Inhibits MLC phosphorylation and blocks motility and invasion of SCC12 squamous cell carcinoma.
- Topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.
Medchemexpress LLC MST-312, chemically modified derivative of epigallocatechin gallate | 368449-04-1 | 98.6% | 100 MG
MST-312 is a small-molecule telomerase inhibitor derived from epigallocatechin gallate (EGCG), intended for research use in oncology and cellular studies. It is available both as a solid and as a DMSO solution for in vitro assays.
- Telomerase inhibitor used in cancer research.
- Purity 98.6%.
- Molecular formula C20H16N2O6.
- Molecular weight 380.35 g/mol.
- CAS number 368449-04-1.
- Available as solid (5-500 mg) and 10 mM solution in DMSO.
![Medchemexpress LLC 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol | 315698-36-3 | MFCD02330713 | >=98.0% | 354.83 g/mol | C19H19ClN4O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000264404.png-250.jpg)
Medchemexpress LLC 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol | 315698-36-3 | MFCD02330713 | >=98.0% | 354.83 g/mol | C19H19ClN4O | 5 MG
MLS1547 is a small-molecule, G protein-biased agonist of the dopamine D2 receptor used in research to probe receptor signaling bias. It preferentially stimulates G protein-mediated signaling with micromolar potency while showing reduced β-arrestin recruitment, making it useful for studies of biased agonism and D2 receptor pharmacology.
- Preferentially activates G protein signaling over β-arrestin pathways.
- D2 receptor agonist activity (Ki ≈ 1.2 μM; EC50 ≈ 0.37 μM).
- Antagonizes dopamine-stimulated β-arrestin recruitment (IC50 ≈ 9.9 μM).
- High purity suitable for biochemical assays (≥98% HPLC).
- Supplied in small research quantities for laboratory studies.
- Store refrigerated at +4 °C to maintain stability.
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran contains 2
The product is tetrahydrofuran (THf) and it contains 250ppm BHT (Butylated hydroxytoluene) as an inhibitor. THf is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THf forms double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1 4-diol is formed as an intermediate during the synthesis of THf. Hot THf is useful for the disSOLUTIONon of polyvinylidene chloride (PVDV).
Medchemexpress LLC 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g·mol⁻¹ | C25H20F3N5O2 | 5 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony-stimulating factor 1 receptor (CSF1R) with a reported IC50 of 0.5 nM. The compound demonstrates good intestinal permeability in Caco-2 assays and favorable oral pharmacokinetics in mice, supporting its use for in vivo pharmacology testing in preclinical tumor models.
- Potent CSF1R inhibition (IC50 = 0.5 nM).
- Good intestinal permeability in Caco-2 assays.
- Favorable oral pharmacokinetics in mice for in vivo studies.
- High purity suitable for research applications.
- Recommended storage as a powder at -20°C to maintain stability.
Medchemexpress LLC BMS-1001 hydrochloride | 2113650-04-5 | 98.0% | 10 MG
BMS-1001 hydrochloride is a small-molecule PD-L1/PD-1 immune checkpoint inhibitor supplied for research use. It binds human PD-L1 and blocks PD-1/PD-L1 interaction, and is used in immunology and cancer research assays.
- Small-molecule PD-L1/PD-1 inhibitor for research use.
- Reported IC50 of 2.25 nM in HTRF binding assay.
- Available as solid and solution forms; common solid sizes include 5 mg-100 mg.
- Typical purity approximately 98.0% by supplier assay.
- Molecular weight 631.11 g/mol and formula C35H35ClN2O7.
Medchemexpress LLC SID7970631 | 868224-75-3 | 98.3% | 100 MG
SID7970631 is an isoquinolinone analog and a potent, selective submicromolar SF-1 inhibitor with an IC50 of 255 nM. It is primarily used for cancer research and exhibits various cytotoxic effects in vitro.
- Potent and selective SF-1 inhibitor (IC50 = 255 nM)
- Isoquinolinone analog
- Useful in cancer research
- Exhibits half-maximal cytotoxic effect in CHO-K1 cells
- Dose-dependently inhibits luciferase expression in SF-1 assay
- Demonstrates cytotoxic effect on H295R/TR SF-1 cells and SW-13 cells
Medchemexpress LLC Ro5-3335 | 30195-30-3 | 99.35% | 259.69 | 100 MG
Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. It is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation.
- Exhibits antiproliferative activity against human CBF leukemia cell lines.
- Inhibits definitive hematopoiesis in zebrafish embryos.
- Modifies the conformation or increases the distance between the components of the RUNX1-CBFβ complex.
- Identified as an inhibitor of RUNX1-CBFβ function in zebrafish models.
- Rescues preleukemic phenotype in transgenic zebrafish.
- Reduces leukemia burden in a mouse leukemia model.
Medchemexpress LLC Linzagolix | 935283-04-8 | 99.68% | 508.42 | 100 MG
Linzagolix is a potent, non-peptide, and orally active GnRH antagonist. It can be used for research related to uterine fibroids, endometriosis, and adenomyosis.
- Potent, non-peptide, and orally active GnRH antagonist.
- Can be used for uterine fibroids, endometriosis, and adenomyosis research.
- Reduces cyst volume in a rat model of endometriosis.
- Suppresses hypothalamic-pituitary-gonadal function by reducing serum luteinizing hormone and testosterone levels.
Medchemexpress LLC Nerigliatin | 1245603-92-2 | 99.9% | 432.43 g/mol | C22H20N6O4 | 50 MG
Nerigliatin is an orally active glucokinase activator supplied for research and analytical use. It has been studied for glucose-lowering effects in type 2 diabetes models and is associated with peripheral nerve degeneration in preclinical reports. The compound is provided as a high-purity solid for laboratory experiments.
- Orally active glucokinase activator.
- Intended for research and analytical applications.
- High purity (reported 99.94%).
- Molecular formula C22H20N6O4; molecular weight 432.43 g/mol.
- Available as a 50 mg solid package.
Sigma Aldrich Fine Chemicals Biosciences 2-Methyltetrahydrofuran Bi
We are committed to bringing you Greener Alternative Products which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a biorenewable and thus aligns with Safer Solvents and Auxiliaries and Use of Renewable feedstocks. Click here for more information.2-Methyltetrahydrofuran is an environmentally favorable alternative to tetrahydrofuran (THf) 1 4 Dioxane (Dioxane) and dichloromethane (DCM) for most industrial applications. Many of its benefits include High boiling pointClean organic-water phase separationReduced energy to recover