W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. It inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. It effectively alleviates cancer cell chemoresistance to 5-FU, and regulates the cell cycle, DNA damage response, oxidative phosphorylation, the IL6-JAK-STAT3 pathway, and the ferroptosis pathway.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates the cell cycle
- Regulates DNA damage response
- Regulates oxidative phosphorylation
- Regulates the IL6-JAK-STAT3 pathway
- Regulates the ferroptosis pathway