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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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MD-224 is a small-molecule proteolysis-targeting chimera (PROTAC) that selectively degrades MDM2 for research applications. It shows high cellular potency and is supplied as a solid or as a 10 mM solution in DMSO.
Selective MDM2 degrader for research use
High potency in cellular assays (subnanomolar activity)
Available as solid and 10 mM DMSO solution
High purity suitable for biochemical studies
Molecular formula C48H43Cl2FN6O6; molecular weight 889.80
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Stearic acid-mPEG (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. It can be used in drug delivery research.
PEG lipid
Improves delivery efficiency of poorly soluble drugs
Improves tissue specificity of poorly soluble drugs
Can be used in drug delivery research
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
MD-224 is a PROTAC small-molecule degrader of murine double minute 2 (MDM2) used in research to induce targeted protein degradation and study p53 pathway modulation. It is supplied as a high-purity solid with supporting analytical and safety documentation.
High purity suitable for cellular and in vivo research.
Contains an alkyne group for click chemistry conjugation.
Characterized by LC-MS and supplied with a certificate of analysis and SDS.
Available in multiple pack sizes and solution formats for flexible use.
Potent activity at sub-nanomolar concentrations for MDM2 degradation.
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224-Trimethylpentane (TMP Isooctane) is a saturated branched hydrocarbon. It has been reported to be nephrotoxic to male rats. Density and viscosity of TMP at various temperatures (198K - 348K) and pressures (100MPa) has been evaluated. It has been indentified as nephrotoxicity inducing component in unleaded gasoline.
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An esterified form of 12-oxo stearic acid; has been found in esterified L. chinensis and L. decipiens pulp oils and serves as a measure of 12-oxo stearic acid content
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Dynole 2-24 is an indole-based dynamin GTPase inhibitor used as a research reagent to inhibit dynamin I and II and to block clathrin-mediated endocytosis in cells.
Potent inhibitor of dynamin I (IC50 = 0.56 μM).
Active in cells to inhibit clathrin-mediated endocytosis (IC50 ≈ 1.9 μM).
Shows selectivity for dynamin I over dynamin II (≈4.4-fold).
High purity suitable for biochemical and cellular assays.
Available in small research quantities as an oil for convenient handling.
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